Asymptomatic and Pre-symptomatic Transmission of SARS-CoV-2 in a Community Congregant Setting

NCT ID: NCT05145803

Last Updated: 2021-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

3300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-03-15

Study Completion Date

2022-09-01

Brief Summary

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The overall aim of this study is to measure how transmission of COVID-19 occurs in communities - including the role of super spreaders and/or identifying conditions that may increase transmission risk, with a focus on congregant situations. In order to identify how presence of symptoms and behavior affects the transmissibility of the virus, the investigators will measure SARS-CoV-2 in exhaled breath of asymptomatic and symptomatic persons using polyvinyl alcohol (PVA) test strips embedded in face masks (Face Mask Sampling- "FMS") - an innovative, non-invasive method for detection of SARS-CoV-2 in exhaled air.

Detailed Description

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Conditions

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COVID-19 SARS-CoV2 Infection

Keywords

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COVID-19 Transmission SARS-CoV2 Transmission

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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College Students

Collegiate students tested positive for SARS-CoV-2 by a molecular reference test (PCR test or antigen test) (index patients).

Collegiate students known to be contacts of the index patients.

Polyvinylalcohol strip [diagnostic]

Intervention Type DEVICE

The investigators will measure SARS-CoV-2 in exhaled breath of asymptomatic and symptomatic persons using PVA test strips embedded in face masks (FMS) - an innovative, non-invasive method for detection of SARS-CoV-2 in exhaled air. Utilizing this approach, the study aims to utilize the test results extracted from the masks to identify risk factors for SARS-CoV-2 transmission and timing of infectious period in exposed people (pre-symptomatic, asymptomatic, and symptomatic).

Interventions

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Polyvinylalcohol strip [diagnostic]

The investigators will measure SARS-CoV-2 in exhaled breath of asymptomatic and symptomatic persons using PVA test strips embedded in face masks (FMS) - an innovative, non-invasive method for detection of SARS-CoV-2 in exhaled air. Utilizing this approach, the study aims to utilize the test results extracted from the masks to identify risk factors for SARS-CoV-2 transmission and timing of infectious period in exposed people (pre-symptomatic, asymptomatic, and symptomatic).

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Individuals age ≥ 18 years of any gender tested positive for SARS-CoV-2 by a molecular reference test (PCR test or antigen test) \[INDEX PATIENTS\]
* Individuals age ≥ 18 years and known to be contacts of the index patients \[CONTACTS\]

Exclusion Criteria

* \< age 18 years old, unable to wear a face mask due to underlying condition, not able to consent, pregnancy. In addition, signs of severe disease present at time of enrollment (e.g. difficulty breathing, pain when breathing, tightness of chest or developing irregular heart beat).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Colorado State University

OTHER

Sponsor Role collaborator

University of Colorado, Boulder

OTHER

Sponsor Role collaborator

Colorado Mesa University

OTHER

Sponsor Role collaborator

Regis University

OTHER

Sponsor Role collaborator

Denver Health Medical Center

OTHER

Sponsor Role collaborator

University of Colorado, Colorado Springs

OTHER

Sponsor Role collaborator

University of Colorado, Denver

OTHER

Sponsor Role collaborator

Colorado School of Public Health

OTHER

Sponsor Role lead

Responsible Party

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Thomas Jaenisch

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Geoffrey Winstanley, PharmD

Role: STUDY_DIRECTOR

Colorado School of Public Health

Molly Lamb, PhD

Role: PRINCIPAL_INVESTIGATOR

Colorado School of Public Health

May Chu, PhD

Role: PRINCIPAL_INVESTIGATOR

Colorado School of Public Health

Thomas Jaenisch, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Colorado School of Public Health

Locations

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Anschutz Medical Campus

Aurora, Colorado, United States

Site Status RECRUITING

University of Colorado, Boulder

Boulder, Colorado, United States

Site Status RECRUITING

University of Colorado, Colorado Springs

Colorado Springs, Colorado, United States

Site Status RECRUITING

Denver Health

Denver, Colorado, United States

Site Status RECRUITING

Regis University

Denver, Colorado, United States

Site Status RECRUITING

Colorado State University

Fort Collins, Colorado, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Thomas Jaenisch, MD, PhD

Role: CONTACT

Phone: 720-626-1094

Email: [email protected]

May Chu, PhD

Role: CONTACT

Email: [email protected]

Facility Contacts

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Brian Montague, DO

Role: primary

Leisha Conners Bauer, MPA

Role: primary

Stephanie Hanenberg, MSN

Role: primary

Kellie Hawkins, MD

Role: primary

Stephanie James, PhD

Role: primary

Jeannine Riess

Role: primary

References

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Jaenisch T, Lamb MM, Gallichotte EN, Adams B, Henry C, Riess J, van Sickle JT, Hawkins KL, Montague BT, Coburn C, Conners Bauer L, Kovarik J, Hernandez MT, Bronson A, Graham L, James S, Hanenberg S, Kovacs J, Spencer JS, Zabel M, Fox PD, Pluss O, Windsor W, Winstanley G, Olson D, Barer M, Berman S, Ebel G, Chu M. Investigating transmission of SARS-CoV-2 using novel face mask sampling: a protocol for an observational prospective study of index cases and their contacts in a congregate setting. BMJ Open. 2022 Nov 23;12(11):e061029. doi: 10.1136/bmjopen-2022-061029.

Reference Type DERIVED
PMID: 36418127 (View on PubMed)

Other Identifiers

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21-2823

Identifier Type: -

Identifier Source: org_study_id