Trial Outcomes & Findings for Using MOST to Optimize an Intervention to Increase COVID-19 Testing for Frontline Essential Workers (NCT NCT05139927)

NCT ID: NCT05139927

Last Updated: 2025-05-16

Results Overview

COVID-19 testing at the 6- and/or 12-week follow-up assessment (at least one instance)

Recruitment status

COMPLETED

Study phase

Target enrollment

438 participants

Primary outcome timeframe

by the 12-week FU

Results posted on

2025-05-16

Participant Flow

The optimization randomized controlled trial described here was conducted in New York City between July 2022 and February 2024. The trial was a collaboration between New York University and the Northern Manhattan Improvement Corporation. Study activities were conducted at a research field site in lower Manhattan. Persons could participate there in-person or engage in the study virtually. Recruitment took place in the community,

Participant milestones

Participant milestones
Measure	Condition 1 Component A: MIC - ON Component B: TM - ON Component C: PE- ON Component D: Navigation	Condition 2 Component A: motivational interviewing counseling - ON Component B: Text message intervention - ON Component C: Peer education - ON Component D: Self-test kit	Condition 3 Component A: motivational interviewing counseling - OFF Component B: Text message intervention - ON Component C: Peer education - ON Component D: Navigation	Condition 4 Component A: motivational interviewing counseling - OFF Component B: Text message intervention - ON Component C: Peer education - ON Component D: Self-test kit	Condition 5 Component A: motivational interviewing counseling - ON Component B: Text message intervention - OFF Component C: Peer education - ON Component D: Navigation	Condition 6 Component A: motivational interviewing counseling - ON Component B: Text message intervention - OFF Component C: Peer education - ON Component D: Self-test kit	Condition 7 Component A: motivational interviewing counseling - OFF Component B: Text message intervention - OFF Component C: Peer education - ON Component D: Navigation Peer education: This component has two aspects: Participants are trained to educate their peers on core messages about the importance of COVID-19 testing that address social norms about COVID-19 testing and highlight COVID-19 testing as an altruistic act (15-20 min. training). Then, participants are given the opportunity to educate three peers who are Black and Latino/Hispanic frontline essential workers on the core messages. These peers contact the study directly and receive a brief assessment and referrals to testing, but are not enrolled in the study. Access to COVID testing: Component D is an adaptive intervention component that avoids unnecessary costs; it is only provided if needed. Level 1: Over a 2-3 week period, navigation includes a brief needs assessment and guidance to assist participants in prioritizing, accessing, and completing COVID-19 testing sequences in a timely fashion and resolving barriers such as transportation or the possible need to take off work if diagnosed with COVID-19. Level 2: 1 month after enrollment, participants will be contacted by phone. If they have not been tested, we will provide them with a BinaxNOW test kit which can be picked up or mailed to them.	Condition 8 Component A: motivational interviewing counseling - OFF Component B: Text message intervention - OFF Component C: Peer education - ON Component D: Self-test kit Peer education: This component has two aspects: Participants are trained to educate their peers on core messages about the importance of COVID-19 testing that address social norms about COVID-19 testing and highlight COVID-19 testing as an altruistic act (15-20 min. training). Then, participants are given the opportunity to educate three peers who are Black and Latino/Hispanic frontline essential workers on the core messages. These peers contact the study directly and receive a brief assessment and referrals to testing, but are not enrolled in the study. Access to COVID testing: Component D is an adaptive intervention component that avoids unnecessary costs; it is only provided if needed. Level 1: Over a 2-3 week period, navigation includes a brief needs assessment and guidance to assist participants in prioritizing, accessing, and completing COVID-19 testing sequences in a timely fashion and resolving barriers such as transportation or the possible need to take off work if diagnosed with COVID-19. Level 2: 1 month after enrollment, participants will be contacted by phone. If they have not been tested, we will provide them with a BinaxNOW test kit which can be picked up or mailed to them.	Condition 9 Component A: motivational interviewing counseling - ON Component B: Text message intervention - ON Component C: Peer education - OFF Component D: Navigation	Condition 10 Component A: motivational interviewing counseling - ON Component B: Text message intervention - ON Component C: Peer education - OFF Component D: Self test kit	Condition 11 Component A: motivational interviewing counseling - OFF Component B: Text message intervention - ON Component C: Peer education - OFF Component D: Navigation	Condition 12 Component A: motivational interviewing counseling - OFF Component B: Text message intervention - ON Component C: Peer education - OFF Component D: Self test kit	Condition 13 Component A: motivational interviewing counseling - ON Component B: Text message intervention - OFF Component C: Peer education - OFF Component D: Navigation	Condition 14 Component A: motivational interviewing counseling - ON Component B: Text message intervention - OFF Component C: Peer education - OFF Component D: Self test kit	Condition 15 Component A: motivational interviewing counseling - OFF Component B: Text message intervention - OFF Component C: Peer education - OFF Component D: Navigation	Condition 16 Component A: motivational interviewing counseling - OFF Component B: Text message intervention - OFF Component C: Peer education - OFF Component D: Self test kit
Overall Study STARTED	24	28	28	27	26	28	28	28	27	28	28	28	27	28	28	27
Overall Study COMPLETED	24	28	28	27	26	28	28	28	27	28	28	28	27	28	28	27
Overall Study NOT COMPLETED	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Using MOST to Optimize an Intervention to Increase COVID-19 Testing for Frontline Essential Workers

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Condition 1 n=24 Participants Component A: motivational interviewing counseling - ON Component B: Text message intervention - ON Component C: Peer education - ON Component D: Navigation	Condition 2 n=28 Participants Component A: motivational interviewing counseling - ON Component B: Text message intervention - ON Component C: Peer education - ON Component D: Self-test kit	Condition 3 n=28 Participants Component A: motivational interviewing counseling - OFF Component B: Text message intervention - ON Component C: Peer education - ON Component D: Navigation	Condition 4 n=27 Participants Component A: motivational interviewing counseling - OFF Component B: Text message intervention - ON Component C: Peer education - ON Component D: Self-test kit	Condition 5 n=26 Participants Component A: motivational interviewing counseling - ON Component B: Text message intervention - OFF Component C: Peer education - ON Component D: Navigation	Condition 6 n=28 Participants Component A: motivational interviewing counseling - ON Component B: Text message intervention - OFF Component C: Peer education - ON Component D: Self-test kit	Condition 7 n=28 Participants Component A: motivational interviewing counseling - OFF Component B: Text message intervention - OFF Component C: Peer education - ON Component D: Navigation	Condition 8 n=28 Participants Component A: motivational interviewing counseling - OFF Component B: Text message intervention - OFF Component C: Peer education - ON Component D: Self-test kit	Condition 9 n=27 Participants Component A: motivational interviewing counseling - ON Component B: Text message intervention - ON Component C: Peer education - OFF Component D: Navigation	Condition 10 n=28 Participants Component A: motivational interviewing counseling - ON Component B: Text message intervention - ON Component C: Peer education - OFF Component D: Self test kit	Condition 11 n=28 Participants Component A: motivational interviewing counseling - OFF Component B: Text message intervention - ON Component C: Peer education - OFF Component D: Navigation	Condition 12 n=28 Participants Component A: motivational interviewing counseling - OFF Component B: Text message intervention - ON Component C: Peer education - OFF Component D: Self test kit	Condition 13 n=27 Participants Component A: motivational interviewing counseling - ON Component B: Text message intervention - OFF Component C: Peer education - OFF Component D: Navigation	Condition 14 n=28 Participants Component A: motivational interviewing counseling - ON Component B: Text message intervention - OFF Component C: Peer education - OFF Component D: Self test kit	Condition 15 n=28 Participants Component A: motivational interviewing counseling - OFF Component B: Text message intervention - OFF Component C: Peer education - OFF Component D: Navigation	Condition 16 n=27 Participants Component A: motivational interviewing counseling - OFF Component B: Text message intervention - OFF Component C: Peer education - OFF Component D: Self test kit	Total n=438 Participants Total of all reporting groups
Age, Continuous	37.46 years STANDARD_DEVIATION 10.56 • n=5 Participants	36.07 years STANDARD_DEVIATION 8.73 • n=7 Participants	33.54 years STANDARD_DEVIATION 10.12 • n=5 Participants	39.44 years STANDARD_DEVIATION 12.07 • n=4 Participants	35.19 years STANDARD_DEVIATION 11.18 • n=21 Participants	35.29 years STANDARD_DEVIATION 9.56 • n=8 Participants	33.82 years STANDARD_DEVIATION 9 • n=8 Participants	31.82 years STANDARD_DEVIATION 8.46 • n=24 Participants	35.37 years STANDARD_DEVIATION 7.75 • n=42 Participants	36.04 years STANDARD_DEVIATION 11.44 • n=42 Participants	35.64 years STANDARD_DEVIATION 9.19 • n=42 Participants	35.54 years STANDARD_DEVIATION 10.07 • n=42 Participants	32.59 years STANDARD_DEVIATION 8.66 • n=36 Participants	33.89 years STANDARD_DEVIATION 9.32 • n=36 Participants	34.75 years STANDARD_DEVIATION 9.16 • n=24 Participants	32.41 years STANDARD_DEVIATION 9.11 • n=135 Participants	34.93 years STANDARD_DEVIATION 9.65 • n=136 Participants
Sex/Gender, Customized Man/male gender	8 Participants n=5 Participants	12 Participants n=7 Participants	20 Participants n=5 Participants	15 Participants n=4 Participants	15 Participants n=21 Participants	16 Participants n=8 Participants	12 Participants n=8 Participants	16 Participants n=24 Participants	12 Participants n=42 Participants	14 Participants n=42 Participants	14 Participants n=42 Participants	19 Participants n=42 Participants	13 Participants n=36 Participants	16 Participants n=36 Participants	13 Participants n=24 Participants	14 Participants n=135 Participants	229 Participants n=136 Participants
Sex/Gender, Customized Female/woman or gender minority	16 Participants n=5 Participants	16 Participants n=7 Participants	8 Participants n=5 Participants	12 Participants n=4 Participants	11 Participants n=21 Participants	12 Participants n=8 Participants	16 Participants n=8 Participants	12 Participants n=24 Participants	15 Participants n=42 Participants	14 Participants n=42 Participants	14 Participants n=42 Participants	9 Participants n=42 Participants	14 Participants n=36 Participants	12 Participants n=36 Participants	15 Participants n=24 Participants	13 Participants n=135 Participants	209 Participants n=136 Participants
Race/Ethnicity, Customized African American/Black or bi- or multi-racial	11 Participants n=5 Participants	11 Participants n=7 Participants	15 Participants n=5 Participants	13 Participants n=4 Participants	15 Participants n=21 Participants	12 Participants n=8 Participants	15 Participants n=8 Participants	18 Participants n=24 Participants	10 Participants n=42 Participants	16 Participants n=42 Participants	12 Participants n=42 Participants	12 Participants n=42 Participants	13 Participants n=36 Participants	11 Participants n=36 Participants	17 Participants n=24 Participants	13 Participants n=135 Participants	214 Participants n=136 Participants
Race/Ethnicity, Customized Other race	13 Participants n=5 Participants	17 Participants n=7 Participants	13 Participants n=5 Participants	14 Participants n=4 Participants	11 Participants n=21 Participants	16 Participants n=8 Participants	13 Participants n=8 Participants	10 Participants n=24 Participants	17 Participants n=42 Participants	12 Participants n=42 Participants	16 Participants n=42 Participants	16 Participants n=42 Participants	14 Participants n=36 Participants	17 Participants n=36 Participants	11 Participants n=24 Participants	14 Participants n=135 Participants	224 Participants n=136 Participants
Race/Ethnicity, Customized Latino/Hispanic (yes)	13 Participants n=5 Participants	17 Participants n=7 Participants	13 Participants n=5 Participants	14 Participants n=4 Participants	11 Participants n=21 Participants	16 Participants n=8 Participants	13 Participants n=8 Participants	10 Participants n=24 Participants	17 Participants n=42 Participants	12 Participants n=42 Participants	16 Participants n=42 Participants	16 Participants n=42 Participants	14 Participants n=36 Participants	17 Participants n=36 Participants	11 Participants n=24 Participants	14 Participants n=135 Participants	224 Participants n=136 Participants

PRIMARY outcome

Timeframe: by the 12-week FU

Population: participants

COVID-19 testing at the 6- and/or 12-week follow-up assessment (at least one instance)