MedDataX Logo

Emotion and Cognitive Function and Brain Imaging Change in HD Patients

NCT ID: NCT05137470

Last Updated: 2021-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-01

Study Completion Date

2025-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

1. Observe the influence of entering hemodialysis treatment on the emotional and cognitive functions of ESRD patients.
2. Observe the influence of entering hemodialysis treatment on the brain structure imaging of ESRD patients.
3. Analyze and study the relevant clinical risk factors of the above-mentioned effects, and find targets for therapeutic intervention.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Select uremic patients and maintenance hemodialysis patients admitted to the Central Dialysis Room of Beijing Friendship Hospital, Capital Medical University from 2021, to collect and sort out the demographic characteristics of the patients: gender, age, clinical characteristics: primary disease, complications and Complications, body mass index (BMI), residual renal function, etc., clinical examination indicators: hemoglobin, blood calcium, blood phosphorus, blood PTH, blood albumin, URR, etc., hemodialysis treatment parameters: dialysis mode, dialyzer model, vascular access , Blood flow, etc., record the patient's emotional and cognitive function status, various clinical indicators and changes in the patient's quality of life before and after the start of treatment, and use multimodal magnetic resonance neuroimaging research sequences to analyze the changes in the patient's brain structure and function.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Kidney Failure, Chronic Cognitive Dysfunction Magnetic Resonance Imaging

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Newly HD patients

Newly admitted patients with uremia who started hemodialysis treatment

This is an observational study

Intervention Type OTHER

This is an observational study

MHD patients

Maintenance hemodialysis patients

This is an observational study

Intervention Type OTHER

This is an observational study

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

This is an observational study

This is an observational study

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients who are new to hemodialysis treatment, and those who are on regular hemodialysis treatment for ≥6 months.
* Age ≥ 18 years old.

Exclusion Criteria

* There was already a severe central nervous system disease before dialysis.
* Hearing and visual impairment cannot communicate or cooperate.
* Mental illness and incapacity.
* The magnetic resonance examination could not be completed for various reasons.
* Life expectancy with serious diseases is less than 6 months.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Beijing Friendship Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

WENHU LIU, doctor

Role: STUDY_DIRECTOR

Beijing Friendship Hospital

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

China

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

XU LIU, master

Role: CONTACT

Phone: +86-010-63138579

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

XU LIU, master

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

YYYXYJ-2021-275

Identifier Type: -

Identifier Source: org_study_id