Study of Intra-Cardiac Echocardiography in Guiding Left Atrial Appendage Occlusion With the Watchman Device

NCT ID: NCT05136417

Last Updated: 2024-12-27

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-04

Study Completion Date

2023-12-15

Brief Summary

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The purpose of this research is to to assess the feasibility and safety of left atrial appendage (LAA) occlusion with the WATCHMAN FLX™ device using a standardized intra-procedural intracardiac echocardiography (ICE) protocol under moderate sedation for procedural guidance.

Detailed Description

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Conditions

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Left Atrial Appendage Occlusion

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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left atrial appendage (LAA) occlusion with the WATCHMAN FLX device using (ICE)

100 patients undergoing LAA closure with the WATCHMAN FLX utilizing an intra-procedural ICE probe under moderate sedation.

Group Type EXPERIMENTAL

intra-procedural intracardiac echocardiography (ICE) probe

Intervention Type DEVICE

placing the WATCHMAN FLX device using the intra-procedural intracardiac echocardiography (ICE) probe.

Interventions

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intra-procedural intracardiac echocardiography (ICE) probe

placing the WATCHMAN FLX device using the intra-procedural intracardiac echocardiography (ICE) probe.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* The patients is eligible to undergo WATCHMAN device implant procedure.
* The patient is eligible for short term anticoagulation therapy.
* Ability to tolerate the procedure without the need for general anesthesia as assessed by the treating physician(s).
* Ability to give informed consent for the procedure.
* The patient is able and willing to undergo the procedure under moderate sedation.
* The patient is able and willing to return for required 45-day transesophageal echocardiogram (TEE).

Exclusion Criteria

* Patient has contraindication for short term anticoagulation.
* The patient has history of a hypercoagulable state per medical record documentation.
* Pregnancy or planning to get pregnant during the investigation.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mayo Clinic

OTHER

Sponsor Role lead

Responsible Party

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Mohamad Adnan Alkhouli

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mohamad Adnan Alkhouli, MD

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Locations

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Pacific Heart Institute

Santa Monica, California, United States

Site Status

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Other Identifiers

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21-009613

Identifier Type: -

Identifier Source: org_study_id