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Cardiac Autonomic Modulation in Older Hypertensive Individuals Submitted to Different Types of Physical Training

NCT ID: NCT05135247

Last Updated: 2021-11-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

61 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-10

Study Completion Date

2017-07-10

Brief Summary

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Sixty-one sedentary older hypertensive individuals were randomized to four groups: continuous aerobic training (CA), interval aerobic training (IA), resistance training (R), and control (C) group. The protocol included 3 sessions of training by week for 12 weeks. C individuals were instructed to continue their usual activities. They were submitted to the passive tilt test before and after the research protocol, evaluating the heart rate (HR), low frequency (LF) and high frequency (HF) bands, detrended fluctuation analysis (DFAα1) and entropy

Detailed Description

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The individuals were randomized into four groups: continuous aerobic training (CA), interval aerobic training (IA), resistance training (R), and control (C), which performed physical exercises three times a week for twelve weeks, with a total of 36 sessions. The tilt test was performed before and after the research protocol. Individuals in the control group were only encouraged to maintain their usual activities.

For the analysis of HRV, the baseline conditions (resting in the supine position) were determined, followed by the passive postural maneuver, which characterizes the tilt test (table til tat 70 °) in order to determine the following variables:

* HR: heart rate (sympathetic action)
* LF: Low frequency band (Modulated predominantly by the sympathetic system)
* HF: High frequency band (Modulated predominantly by the parasympathetic system)
* Entropy: data complexity or irregularity index showing that, the higher the values, the better the HRV.
* DFAα1 (short term detrended fluctuation analysis)

Conditions

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Autonomic Dysfunction

Keywords

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older individuals heart rate variability physical training hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The individuals were randomized into four groups: continuous aerobic training (CA), interval aerobic training (IA), resistance training (R), and control (C), which performed physical exercises three times a week for twelve weeks, with a total of 36 sessions. The tilt test was performed before and after the research protocol. Individuals in the control group were only encouraged to maintain their usual activities.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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continuous aerobic training (CA)

The CA group was trained with 70% of maximum heart rate (MHR) for 30 minutes.

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

3 different types of training or control

resistance training (R)

The R sessions consisted of a set of each proposed exercise: sitting bench press, legpress, back row, leg extension, shoulders high pull, seated leg curl, biceps curls, standing calf, triceps in the pulley, and abdominal crunches, with 8 - 10 repetitions with 75% 1MR.

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

3 different types of training or control

interval aerobic training (IA)

The IA group was submitted to exercise intensities of 60% for 2 minutes and 80% for 2 minutes, alternately, with a total of 30 minutes.

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

3 different types of training or control

control (C)

Individuals in the control group maintained their usual activities.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise

3 different types of training or control

Intervention Type OTHER

Eligibility Criteria

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Exclusion Criteria

* • Positive treadmill test (TT) for ischemia

* Related left ventricular systolic dysfunction of any degree
* Presence of arrhythmias
* Use of β-blockers
* Use more than seven doses of ethyl alcohol per week
* Renal insufficiency
* Diabetes
* Hyper- or hypothyroidism
* Limiting lung disease
* Osteomioarticular impairment that would limit exercise performance
* SBP ≥160 and/or DBP ≥ 100 mmHg on baseline
Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Sao Paulo

OTHER

Sponsor Role lead

Responsible Party

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Nereida Kilza da Costa Lima

Associated Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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1.092.824

Identifier Type: -

Identifier Source: org_study_id