A Study to Compare Pharmacokinetic Parameters and Safety Profiles Between AD-109 and AD-1091

NCT ID: NCT05128591

Last Updated: 2022-03-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

38 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-09

Study Completion Date

2021-12-31

Brief Summary

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Primary endpoint of this study is to evaluate the pharmacokinetic characteristics of AD-109 in healthy male subjects.

Detailed Description

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The purpose of this study is to evaluate the pharmacokinetic characteristics and safety profiles of AD-109 compared with AD-1091 in healthy male subjects.

Conditions

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Embolism and Thrombosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Arm A-Rivaroxaban

Period 1 : Reference Drug(AD-1091) Period 2 : Test Drug(AD-109)

Group Type EXPERIMENTAL

Rivaroxaban 18mg Oral Tablet

Intervention Type DRUG

AD-109 (Rivaroxaban 18mg) Oral Tablet

Rivaroxaban 20 MG Oral Tablet

Intervention Type DRUG

AD-1091 (Rivaroxaban 20mg) Oral Tablet

Arm B-Rivaroxaban

Period 1 : Test Drug(AD-109) Period 2 : Reference Drug(AD-1091

Group Type EXPERIMENTAL

Rivaroxaban 18mg Oral Tablet

Intervention Type DRUG

AD-109 (Rivaroxaban 18mg) Oral Tablet

Rivaroxaban 20 MG Oral Tablet

Intervention Type DRUG

AD-1091 (Rivaroxaban 20mg) Oral Tablet

Interventions

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Rivaroxaban 18mg Oral Tablet

AD-109 (Rivaroxaban 18mg) Oral Tablet

Intervention Type DRUG

Rivaroxaban 20 MG Oral Tablet

AD-1091 (Rivaroxaban 20mg) Oral Tablet

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Body weight equal to or greater than 50kg and Body mass index (BMI) between 18.0 kg/m2 and 30.0 kg/m2 at the time of screening visit
* The Age equal to or greater than 19 in healthy male volunteers at the time of screening visit

Exclusion Criteria

* Patients with Medical history increasing the risk of bleeding
Minimum Eligible Age

19 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Addpharma Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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H+ Yangji Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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AD-109BE

Identifier Type: -

Identifier Source: org_study_id

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