A Phase I Study of ZN-d5 in Chinese Subjects With Non-Hodgkin Lymphoma

NCT ID: NCT05127811

Last Updated: 2023-06-02

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE1
• Total Enrollment: 8 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-10-21
• Study Completion Date: 2023-05-26

Brief Summary

A phase I dose-escalation, open-label, multicenter study to assess the safety, tolerability, clinical activity, and pharmacokinetics (PK) of ZN-d5 in Chinese subjects with non-Hodgkin lymphoma (NHL).

Detailed Description

For the Phase I dose escalation study of ZN-d5, it is planned that after the starting dose, subsequent dose assignments will be made by means of a model-assisted design, until the MTD or RP2D is determined in the Chinese population.

Conditions

Non-Hodgkin Lymphoma

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

100mg(on empty)

Group Type: EXPERIMENTAL

ZN-d5

Intervention Type: DRUG

BION design

200mg(on empty)

Group Type: EXPERIMENTAL

ZN-d5

Intervention Type: DRUG

BION design

400mg(on empty)

Group Type: EXPERIMENTAL

ZN-d5

Intervention Type: DRUG

BION design

600mg(on empty)

Group Type: EXPERIMENTAL

ZN-d5

Intervention Type: DRUG

BION design

600mg（with a meal）

Group Type: EXPERIMENTAL

ZN-d5

Intervention Type: DRUG

BION design

800mg(with a meal)

Group Type: EXPERIMENTAL

ZN-d5

Intervention Type: DRUG

BION design

Interventions

ZN-d5

BION design

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. NHL, relapsed from or refractory to at least 2 prior lines of systemic therapy (excluding radiotherapy and surgery); subjects must have failed or not be candidates for available standard therapy expected to provide clinical benefit.

2. Female subjects of childbearing potential must have a negative serum pregnancy test and agree to use contraception while on study.

3. Eastern Cooperative Oncology Group performance status ≤ 1.

4. Adequate blood and other organ function, defined by the following criteria:

1. Neutrophil count (ANC) ≥ 1.0 × 109/L.

2. Platelet count ≥ 75 × 109/L at least 3 days after platelet transfusion (≥ 50 × 109/L permitted if the bone marrow is > 50% lymphoma cells).

3. Hemoglobin ≥ 8.0 g/dL.

4. Coagulation parameters ≤ 1.5 × upper limit of normal (ULN).

5. Liver enzymes ≤ 3 × ULN and total bilirubin ≤ 1.5 × ULN.

6. Creatinine clearance ≥ 60 mL/min.

Exclusion Criteria

1. Received any of the following prior to start of ZN-d5 treatment:

1. Systemic administration of antineoplastic agents (including investigational agents) within the shorter of 28 days or 5 half-lives.

2. Major surgery within 28 days.

3. Radiotherapy within 14 days.

4. Autologous or allogeneic stem cell transplantation within 60 days, or receiving immunosuppression for active graft-versus-host disease.

5. Use of strong CYP3A4 inhibitors, P-gp inhibitors or QT prolonging agents within 5 half-lives, or potent or moderate CYP3A4 inducers within 14 days.

2. Ongoing and clinically significant non-hematologic toxicity related to prior antineoplastic therapy.

3. Presence of major cardiovascular system diseases (including QTcF > 480 msec).

4. Positive serology for human immunodeficiency virus, hepatitis B, or hepatitis C unless no detectable hepatitis B or C viral load.

5. Unable to take oral drugs or presence of severe gastrointestinal abnormalities.

6. Active and uncontrolled clinically significant infection.

7. Other active systemic malignancy or other severe, unstable, or poorly controlled acute or chronic medical conditions.

8. Prior treatment with venetoclax or other BCL-2 inhibitors.

9. Primary or secondary CNS lymphoma.

10. Presence of post-transplant lymphoproliferative disease, Burkitt's lymphoma, Burkitt-like lymphoma, T lymphoblastic lymphoma and T lymphoblastic acute leukemia.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Zentera Therapeutics HK Limited

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

BeiJing Cancer Hospital

Beijing, Beijing Municipality, China

Sun Yan Set University Cancer Center

Guangzhou, Guangdong, China

Fudan University Shanghai Cancer Hospital

Shanghai, Shanghai Municipality, China

Countries

China

Other Identifiers

d5ZTCN100

Identifier Type: -

Identifier Source: org_study_id