Analysis of Breast-Conserving Surgery Plus Whole-Breast Irradiation Versus Mastectomy
NCT ID: NCT05126667
Last Updated: 2021-11-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
9710 participants
OBSERVATIONAL
2000-01-31
2021-11-30
Brief Summary
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Detailed Description
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Recent observations regarding long-term outcomes among patients with early-stage breast cancer who underwent breast-conserving surgery plus whole-breast irradiation or mastectomy are from a small number of registry-based studies.
Therefore, these findings may overestimate differences in survival between the two groups, compared with randomized controlled trials conducted in the 1980s.
This study performed a propensity score-matched analysis in a cohort of 9710 patients aged \<70 years who underwent breast conserving surgery + whole breast irradiation or mastectomy without external radiotherapy for a first primary breast cancer (pT1-2, N0-3a) at the European Institute of Oncology between 2000 and 2008.
Patients were matched by propensity score.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Breast-conserving surgery
Patients who underwent breast-conserving surgery plus whole-breast irradiation
Breast-conserving surgery
Breast conserving surgery plus whole breast irradiation
Mastectomy
Patients who underwent mastectomy
Mastectomy
Breast mastectomy
Interventions
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Breast-conserving surgery
Breast conserving surgery plus whole breast irradiation
Mastectomy
Breast mastectomy
Eligibility Criteria
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Inclusion Criteria
* pT1-2
* pN0-3a
* Surgery performed at European Institute of Oncology between 2000 and 2008
Exclusion Criteria
* Neoadjuvant treatment
* Presence of metastatic breast disease at the time of admission or within 3 months
FEMALE
No
Sponsors
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European Institute of Oncology
OTHER
Responsible Party
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Principal Investigators
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Francesca Magnoni, MD
Role: PRINCIPAL_INVESTIGATOR
European Institute of Oncology
Other Identifiers
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UID 2762
Identifier Type: -
Identifier Source: org_study_id