A Gene Therapy Study of BMN 331 in Subjects With Hereditary Angioedema

NCT ID: NCT05121376

Last Updated: 2024-05-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE1/PHASE2

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-15

Study Completion Date

2028-11-30

Brief Summary

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This is a Phase 1/2, single-arm, open-label, dose-escalation and dose-expansion study of BMN 331 for the treatment of hereditary angioedema (HAE) due to C1 Esterase Inhibitor (C1-INH) protein deficiency. The study drug BMN 331is identified as AAV5 hSERPING1, an adeno-associated virus (AAV5)-based gene therapy vector that expresses wild-type human C1 Esterase Inhibitor (hC1-INH), under the control of a liver-selective promoter, and is being developed for the treatment of HAE with C1-INH deficiency. The pharmaceutical form of BMN 331 is a solution for intravenous infusion.

Detailed Description

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BMN 331 is an investigational, single administration gene therapy intended to modify the disease course of HAE. Preclinical studies have shown that BMN 331 can transduce hepatocytes resulting in restoration of the deficient circulating levels of hC1-INH that cause HAE.

Study 331-201 is a two-part (part A and part B), first-in-human, Phase 1/2 study designed to assess the safety and efficacy of BMN 331 in patients with HAE. Subjects will be followed for 5 years following BMN 331 infusion. Part A of the study is a dose escalation phase designed to assess the preliminary safety of a single IV administration of BMN 331 and to determine whether there is a dose-dependent increase in C1-INH protein expression following administration of BMN 331. Part B is a dose expansion phase designed to demonstrate that up to three safe doses of BMN 331 (as determined in Part A) sustains a clinically meaningful increase in C1-INH levels.

Conditions

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Hereditary Angioedema HAE

Study Design

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Allocation Method

NA

Intervention Model

SEQUENTIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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BMN 331

AAV Gene Therapy Infusion

Group Type EXPERIMENTAL

Dose 1 of BMN 331

Intervention Type GENETIC

BMN 331 AAV Gene Therapy

Dose 2 of BMN 331

Intervention Type GENETIC

BMN 331 AAV Gene Therapy

Dose 3 of BMN 331

Intervention Type GENETIC

BMN 331 AAV Gene Therapy

Dose 4 of BMN 331

Intervention Type GENETIC

BMN 331 AAV Gene Therapy

Dose 5 of BMN 331

Intervention Type GENETIC

BMN 331 AAV Gene Therapy

Dose 6 of BMN 331

Intervention Type GENETIC

BMN 331 AAV Gene Therapy

Dose 7 of BMN 331

Intervention Type GENETIC

BMN 331 AAV Gene Therapy

Interventions

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Dose 1 of BMN 331

BMN 331 AAV Gene Therapy

Intervention Type GENETIC

Dose 2 of BMN 331

BMN 331 AAV Gene Therapy

Intervention Type GENETIC

Dose 3 of BMN 331

BMN 331 AAV Gene Therapy

Intervention Type GENETIC

Dose 4 of BMN 331

BMN 331 AAV Gene Therapy

Intervention Type GENETIC

Dose 5 of BMN 331

BMN 331 AAV Gene Therapy

Intervention Type GENETIC

Dose 6 of BMN 331

BMN 331 AAV Gene Therapy

Intervention Type GENETIC

Dose 7 of BMN 331

BMN 331 AAV Gene Therapy

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

1. Female or male adults ( ≥ 18 years old)
2. Part A only: Confirmed diagnosis of Type I HAE due to C1-INH deficiency confirmed by genotyping of the SERPING1 gene Part B only: Confirmed diagnosis of Type I or II HAE due to C1-INH deficiency confirmed by genotyping of the SERPING1 gene
3. Currently using an HAE medication regimen that consists of a routine long-term prophylactic treatment for at least 6 months prior to enrollment or an on-demand therapy regimen for a documented attack frequency of at least 4 attacks within the last 12 months prior to enrollment or at least 2 attacks within the last 6 months prior to enrollment
4. Trained in self-administering acute attack treatment and is able to adequately manage acute attacks in a home setting
5. Willingness to abstain from consumption of alcohol for at least 52 weeks post BMN 331 infusion and to use highly effective contraception

Exclusion Criteria

1. Evidence of active or chronic infection, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or any immunosuppressive disorder
2. Contraindication to using glucocorticosteroids GCS, including a diagnosis of glaucoma or untreated osteoporosis
3. Active malignancy (except non-melanoma skin cancer) autoimmune, metabolic (i.e., diabetes), hematologic, cardiac, or renal disease that is of clinical significance defined as requiring regular medical attention and treatment
4. Prior gene therapy treatment
5. Prior use of high-dose attenuated androgens in the last 1 year prior to the study
6. History or current clinically relevant liver disease (eg, nonalcoholic steatohepatitis \[NASH\], or chronic viral hepatitis B or C \[HBV or HCV\] or autoimmune hepatitis)
7. Have a history or are at risk for clinically significant thromboembolic events (TEE) , or known underlying risk factor for thrombosis including thrombotic microangiopathy (TMA)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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BioMarin Pharmaceutical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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MD Medical Director

Role: STUDY_DIRECTOR

BioMarin Pharmaceutical

Locations

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AllerVie Clinical Research

Birmingham, Alabama, United States

Site Status

Medical Research of Arizona

Scottsdale, Arizona, United States

Site Status

University of California San Diego

San Diego, California, United States

Site Status

Asthma & Allergy Associates P.C.

Colorado Springs, Colorado, United States

Site Status

Dr. Henry J. Kanarek Allergy, Asthma & Immunology

Overland Park, Kansas, United States

Site Status

Institute For Asthma & Allergy

Chevy Chase, Maryland, United States

Site Status

Mississippi Center for Advanced Medicine

Madison, Mississippi, United States

Site Status

Washington University School of Medicine

St Louis, Missouri, United States

Site Status

Duke Health

Durham, North Carolina, United States

Site Status

University of Cincinnati (UC) Physicians Company, LLC

Cincinnati, Ohio, United States

Site Status

Optimed Research, LTD

Columbus, Ohio, United States

Site Status

The Pennsylvania State University (Penn State) Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

Site Status

AARA Research Center

Dallas, Texas, United States

Site Status

Royal Prince Alfred Hospital,

Camperdown, , Australia

Site Status

Hospital Universitario Vall d'Hebron

Barcelona, , Spain

Site Status

Hospital Universitario La Paz

Madrid, , Spain

Site Status

Countries

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United States Australia Spain

Other Identifiers

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331-201

Identifier Type: -

Identifier Source: org_study_id

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