Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
NCT ID: NCT05120518
Last Updated: 2024-11-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
150 participants
OBSERVATIONAL
2019-08-14
2029-08-14
Brief Summary
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Detailed Description
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This model system will then be subjected to 1) comprehensive histopathological and molecular characterizations during serial in vivo sub-transplantations; 2) cryopreserved for long term preservation of tumorigenicity; and 3) used for future biological studies and preclinical drug testing.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Pediatric patients with cancer and non-cancer tumor types
Pediatric patients with cancer and non-cancer tumor types (solid, liquid, neuro-oncology and stem cell)
Collection of post mortem tissue donation
Collection of post mortem tissue from pediatric participants with cancer and non-cancer tumor types from whom post mortem tissue donation and autopsy consent is obtained.
Interventions
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Collection of post mortem tissue donation
Collection of post mortem tissue from pediatric participants with cancer and non-cancer tumor types from whom post mortem tissue donation and autopsy consent is obtained.
Eligibility Criteria
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Inclusion Criteria
* Signed consent for post mortem tissue donation and autopsy
Exclusion Criteria
ALL
No
Sponsors
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Ann & Robert H Lurie Children's Hospital of Chicago
OTHER
Responsible Party
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Angela Waanders
Principle Investigator
Principal Investigators
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Angela Waanders, MD
Role: PRINCIPAL_INVESTIGATOR
Ann & Robert H Lurie Children's Hospital of Chicago
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Baker JN, Windham JA, Hinds PS, Gattuso JS, Mandrell B, Gajjar P, West NK, Hammarback T, Broniscer A. Bereaved parents' intentions and suggestions about research autopsies in children with lethal brain tumors. J Pediatr. 2013 Aug;163(2):581-6. doi: 10.1016/j.jpeds.2013.01.015. Epub 2013 Feb 19.
Broniscer A, Baker JN, Baker SJ, Chi SN, Geyer JR, Morris EB, Gajjar A. Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma. Cancer. 2010 Oct 1;116(19):4632-7. doi: 10.1002/cncr.25405.
Wiener L, Sweeney C, Baird K, Merchant MS, Warren KE, Corner GW, Roberts KE, Lichtenthal WG. What do parents want to know when considering autopsy for their child with cancer? J Pediatr Hematol Oncol. 2014 Aug;36(6):464-70. doi: 10.1097/MPH.0000000000000078.
Alabran JL, Hooper JE, Hill M, Smith SE, Spady KK, Davis LE, Peterson LS, Malempati S, Ryan CW, Acosta R, Spunt SL, Keller C. Overcoming autopsy barriers in pediatric cancer research. Pediatr Blood Cancer. 2013 Feb;60(2):204-9. doi: 10.1002/pbc.24320. Epub 2012 Sep 26.
Meeting Minutes: Enhancing Biobanking for Childhood Cancers, NCI, May 13, 2019
Related Links
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Related Info
Related Info
Other Identifiers
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2019-2982
Identifier Type: -
Identifier Source: org_study_id
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