Influence of Preoperative Nutritional Status on Perioperative Period in Cardiac Surgery in Patients With Frailty

NCT ID: NCT05118165

Last Updated: 2021-11-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

176 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-12

Study Completion Date

2023-07-11

Brief Summary

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The aim of the study is to determine whether the optimisation of the preoperative nutritional status affects the course of the perioperative period in patients with frailty.

Subjects: Patients 65 and over years of age with frailty or risk of it, with suboptimal nutritional status who are prescribed to elective cardiac surgery .

Research methods: Edmonton Crispness Scale, a Mini Nutritional Assessment (MNA-SF) test will be used to select subjects. Body composition will be examined by bioelectrical impedance analysis (BIA) to determine the degree of phase angle. Changes in laboratory blood tests will be recorded and evaluated The subjects randomly will be divided into control and study groups.

The diet of the patients in the study group will be optimised by protein supplements before elective heart surgery.

The benefits of optimising nutritional status will be evaluated comparing laboratory blood tests, changes in organ function, adverse outcomes, the need for vasoactive drugs, artificial lung ventilation time and length of hospitalisation between the groups.

Detailed Description

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Conditions

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Malnutrition; Protein Frail Elderly Syndrome

Keywords

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preoperative malnutrition frailty cardiac surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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control group

Group Type NO_INTERVENTION

No interventions assigned to this group

intervention group

Group Type EXPERIMENTAL

Dietary supplement with protein

Intervention Type DIETARY_SUPPLEMENT

Will be included protein supplements in the preoperative diet.

Interventions

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Dietary supplement with protein

Will be included protein supplements in the preoperative diet.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Patients 65 years of age and older.
* Patients for whom cardiac surgery will be performed on a scheduled basis.
* Patients able to move without the help of others except for an aid: a stick, a walker.
* Patients who speak and understand Lithuanian perfectly.
* Patients who have read the informed consent form and confirmed their consent to participate in the study in writing.

Exclusion Criteria

* Patiens younger than 65 years.
* No written consent of a person to participate in a biomedical research has been obtained;
* Patients with a history of mental illness or central nervous system disorders that interfere with the perception and proper assessment of their health and the meaning and content of the questionnaire / tasks.
* Patients with amputated lower extremities.
* Patients with hepatic insufficiency, one or more of viral hepatitis.
* It is not possible to perform a qualitative physical examination for other reasons (hearing, vision, etc.)
* Allergy to B vitamins.
Minimum Eligible Age

65 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Lithuanian University of Health Sciences

OTHER

Sponsor Role lead

Responsible Party

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Ingrida Drigotiene

dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Ingrida DrigotienÄ—, m.d.

Role: CONTACT

Phone: +37065222724

Email: [email protected]

Other Identifiers

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SUT_SAI

Identifier Type: OTHER

Identifier Source: secondary_id

SAI

Identifier Type: -

Identifier Source: org_study_id