Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65)

NCT ID: NCT05116189

Last Updated: 2025-07-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

643 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-12-13

Study Completion Date

2028-10-25

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The primary objective is to compare pembrolizumab plus paclitaxel with or without bevacizumab to placebo plus paclitaxel with or without bevacizumab, with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as assessed by the investigator. The hypotheses are that pembrolizumab plus paclitaxel with or without bevacizumab is superior to placebo plus paclitaxel with or without bevacizumab, with respect to PFS per RECIST 1.1 as assessed by the investigator for participants with programmed cell death ligand 1 (PD-L1) positive tumors (Combined Positive Score \[CPS\] ≥1) and that pembrolizumab plus paclitaxel with or without bevacizumab is superior to placebo plus paclitaxel with or without bevacizumab, with respect to PFS per RECIST 1.1 as assessed by the investigator for all participants.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Ovarian Cancer Carcinoma, Ovarian Epithelial Fallopian Tube Neoplasms

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Pembrolizumab + paclitaxel ± bevacizumab

Participants receive pembrolizumab 400 mg via intravenous (IV) infusion for eighteen 6-week cycles (approximately 2 years) PLUS paclitaxel 80 mg/m\^2 via IV infusion on Days 1, 8, and 15 of each 3-week cycle until intolerance or disease progression. Participants who experience severe hypersensitivity reaction to paclitaxel or an AE requiring discontinuation of paclitaxel may receive docetaxel (75 mg/m\^2 every 3 weeks \[Q3W\]) after Sponsor consultation. Participants may also receive bevacizumab 10 mg/kg via IV infusion of each 2-week cycle until intolerance, disease progression, or at the Investigator's discretion.

Group Type EXPERIMENTAL

Pembrolizumab

Intervention Type BIOLOGICAL

IV infusion

Paclitaxel

Intervention Type DRUG

IV infusion

Bevacizumab

Intervention Type DRUG

IV infusion

Docetaxel

Intervention Type DRUG

IV infusion

Placebo + paclitaxel ± bevacizumab

Participants receive placebo via IV infusion for eighteen 6-week cycles (approximately 2 years) PLUS paclitaxel 80 mg/m\^2 via IV infusion on Days 1, 8, and 15 of each 3-week cycle until intolerance or disease progression. Participants who experience severe hypersensitivity reaction to paclitaxel or an AE requiring discontinuation of paclitaxel may receive docetaxel (75 mg/m\^2 every 3 weeks \[Q3W\]) after Sponsor consultation. Participants may also receive bevacizumab 10 mg/kg via IV infusion of each 2-week cycle until intolerance, disease progression, or at the Investigator's discretion.

Group Type PLACEBO_COMPARATOR

Paclitaxel

Intervention Type DRUG

IV infusion

Bevacizumab

Intervention Type DRUG

IV infusion

Placebo for pembrolizumab

Intervention Type OTHER

IV infusion

Docetaxel

Intervention Type DRUG

IV infusion

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Pembrolizumab

IV infusion

Intervention Type BIOLOGICAL

Paclitaxel

IV infusion

Intervention Type DRUG

Bevacizumab

IV infusion

Intervention Type DRUG

Placebo for pembrolizumab

IV infusion

Intervention Type OTHER

Docetaxel

IV infusion

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

MK-3475, KEYTRUDA® TAXOL® AVASTIN®, Zirabev normal saline or dextrose TAXOTERE®

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Has histologically confirmed epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.
* Has received 1 or 2 prior lines of systemic therapy for ovarian cancer (OC), including at least 1 prior platinum-based therapy. Participants may have received a prior poly (ADP-ribose) polymerase inhibitor (PARPi), anti-PD-1/anti-PD-L1 therapy, bevacizumab, or hormonal therapy; these will not be considered a separate line of therapy. Any chemotherapy regimen change due to toxicity in the absence of disease progression will be considered part of the same line of therapy.
* Has provided documented informed consent for the study.
* Has radiographic evidence of disease progression within 6 months (180 days) after the last dose of platinum-based chemotherapy for OC (i.e., platinum-resistant disease).
* Is a candidate for paclitaxel chemotherapy (and bevacizumab, if using).
* Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 assessed within 3 days before randomization.
* For a female participant, she is not pregnant or breastfeeding, and at least one of the following conditions applies: Is not a woman of childbearing potential (WOCBP) OR Is a WOCBP and uses a contraceptive method that is highly effective (with a failure rate of \<1% per year).
* Has radiographically evaluable disease, either measurable or nonmeasurable per RECIST 1.1, as assessed by the local site investigator.
* Archival tumor tissue sample or newly obtained core or incisional/excisional biopsy of a tumor lesion not previously irradiated has been provided.
* Have adequate organ function.

Exclusion Criteria

* Has nonepithelial cancers, borderline tumors, mucinous, seromucinous that is predominantly mucinous, malignant Brenner's tumor and undifferentiated carcinoma.
* Has primary platinum-refractory disease, defined as disease that has progressed per radiographic imaging while receiving or within 28 days of the last dose of first-line platinum-based therapy.
* Has prior disease progression on weekly paclitaxel alone.
* Has received \>2 prior lines of systemic therapy for OC.
* Has received prior systemic anticancer therapy including investigational agents or maintenance therapy (including bevacizumab maintenance therapy), within 4 weeks before randomization.
* Has received prior radiation therapy within 2 weeks of start of study intervention.
* Has not recovered adequately from surgery and/or any complications from the surgery.
* Has received colony-stimulating factors (e.g., granulocyte colony-stimulating factor \[G-CSF\], granulocyte-macrophage colony-stimulating factor,\[GM-CSF\] or recombinant erythropoietin) within 4 weeks before randomization.
* Has received a live or live-attenuated vaccine within 30 days before the first dose of study intervention.
* Has received investigational agent or has used an investigational device within 4 weeks prior to study intervention.
* Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy.
* Has a known additional malignancy that is progressing or has required active treatment within the past 3 years.
* Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis.
* Has severe hypersensitivity (≥Grade 3) to pembrolizumab, paclitaxel, or bevacizumab (if using) and/or any of their excipients.
* Has an active autoimmune disease that has required systemic treatment in the past 2 years.
* Has a history of (noninfectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease.
* Has an active infection requiring systemic therapy.
* Has a known history of human immunodeficiency virus (HIV) infection.
* Has a known history of Hepatitis B or known active Hepatitis C virus infection.
* Has a history or current evidence of any condition, therapy, laboratory abnormality, or other circumstance that might confound the results of the study.
* Has a known psychiatric or substance abuse disorder that would interfere with the participant's ability to cooperate with the requirements of the study.
* Participant, in the judgement of the investigator, is unlikely to comply with the study procedures, restrictions, and requirements of the study.
* Has had an allogenic tissue/solid organ transplant.

For bevacizumab treatment

* Has uncontrolled hypertension.
* Has current, clinically relevant bowel obstruction including related to underlying epithelial OC, abdominal fistula or gastrointestinal perforation, intra-abdominal abscess, or evidence of rectosigmoid involvement by pelvic exam.
* Has a history of thrombotic disorders, hemorrhage, hemoptysis, or active gastrointestinal bleeding within 6 months before randomization.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Medical Director

Role: STUDY_DIRECTOR

Merck Sharp & Dohme LLC

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

HonorHealth ( Site 0041)

Phoenix, Arizona, United States

Site Status

Marin Cancer Care ( Site 0055)

Greenbrae, California, United States

Site Status

Pacific Cancer Care ( Site 0028)

Monterey, California, United States

Site Status

Eisenhower Medical Center ( Site 0067)

Rancho Mirage, California, United States

Site Status

Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 0004)

New Haven, Connecticut, United States

Site Status

University of Florida College of Medicine-UF Health Cancer Center/Clinical Trials Office ( Site 0054

Gainesville, Florida, United States

Site Status

Sarasota Memorial Hospital ( Site 0018)

Sarasota, Florida, United States

Site Status

Moffitt Cancer Center ( Site 0033)

Tampa, Florida, United States

Site Status

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0005)

Marietta, Georgia, United States

Site Status

Advocate Medical Group-Oncology ( Site 0049)

Park Ridge, Illinois, United States

Site Status

Parkview Research Center at Parkview Regional Medical Center ( Site 0027)

Fort Wayne, Indiana, United States

Site Status

St. Vincent Hospital and Health Care Center, Inc ( Site 0032)

Indianapolis, Indiana, United States

Site Status

Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0040)

Edgewood, Kentucky, United States

Site Status

WK Physicians Network / Hematology Oncology Associates ( Site 0034)

Shreveport, Louisiana, United States

Site Status

Mercy Medical Center - Baltimore-Medical Oncology and Hematology ( Site 0015)

Baltimore, Maryland, United States

Site Status

University of Massachusetts Chan Medical School-Division of Gynecologic Oncology ( Site 0003)

Worcester, Massachusetts, United States

Site Status

John Theurer Cancer Center at Hackensack University Medical Center ( Site 0007)

Hackensack, New Jersey, United States

Site Status

Roswell Park Cancer Institute ( Site 0039)

Buffalo, New York, United States

Site Status

Columbia University Medical Center ( Site 0010)

New York, New York, United States

Site Status

Novant Health Presbyterian Medical Center ( Site 0029)

Charlotte, North Carolina, United States

Site Status

Duke Cancer Institute ( Site 0038)

Durham, North Carolina, United States

Site Status

Novant Health Forsyth Medical Center ( Site 0057)

Winston-Salem, North Carolina, United States

Site Status

Aultman Hospital-Oncology Clinical Trials ( Site 0009)

Canton, Ohio, United States

Site Status

MetroHealth Medical Center-Cancer Care Center ( Site 0047)

Cleveland, Ohio, United States

Site Status

Providence Portland Medical Center ( Site 0048)

Portland, Oregon, United States

Site Status

University of Pittsburgh Medical Center Magee-Womens Hospital ( Site 0024)

Pittsburgh, Pennsylvania, United States

Site Status

Sanford Cancer Center ( Site 0064)

Sioux Falls, South Dakota, United States

Site Status

The West Clinic, PLLC dba West Cancer Center ( Site 0058)

Germantown, Tennessee, United States

Site Status

Texas Oncology - Dallas (Presbyterian) ( Site 0065)

Dallas, Texas, United States

Site Status

Texas Oncology - The Woodlands_Lee ( Site 0043)

The Woodlands, Texas, United States

Site Status

Inova Schar Cancer Institute ( Site 0019)

Fairfax, Virginia, United States

Site Status

Westmead Hospital-Department of Gynaecological Oncology ( Site 0201)

Westmead, New South Wales, Australia

Site Status

Gallipoli Medical Research Foundation-GMRF CTU ( Site 0202)

Brisbane, Queensland, Australia

Site Status

Epworth Freemasons ( Site 0204)

Melbourne, Victoria, Australia

Site Status

St. John of God Subiaco Hospital ( Site 0203)

Subiaco, Western Australia, Australia

Site Status

Institut Jules Bordet-Medicine Oncology ( Site 0302)

Brussels, Bruxelles-Capitale, Region de, Belgium

Site Status

UZ Gent-Medical oncology ( Site 0301)

Ghent, Oost-Vlaanderen, Belgium

Site Status

UZ Leuven ( Site 0303)

Leuven, Vlaams-Brabant, Belgium

Site Status

AZ Groeninge Campus Kennedylaan-Oncology ( Site 0305)

Kortrijk, West-Vlaanderen, Belgium

Site Status

Hospital Araújo Jorge ( Site 0401)

Goiânia, Goiás, Brazil

Site Status

Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 0404)

Natal, Rio Grande do Norte, Brazil

Site Status

ANIMI - Unidade de Tratamento Oncologico ( Site 0408)

Lages, Santa Catarina, Brazil

Site Status

BP - A Beneficencia Portuguesa de São Paulo ( Site 0403)

São Paulo, São Paulo, Brazil

Site Status

Núcleo de Pesquisa Clínica da Rede São Camilo ( Site 0405)

São Paulo, São Paulo, Brazil

Site Status

Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA-Pesquisa Clinica HC II ( Site 0402)

Rio de Janeiro, , Brazil

Site Status

Tom Baker Cancer Center ( Site 0511)

Calgary, Alberta, Canada

Site Status

BC Cancer Abbotsford ( Site 0512)

Abbotsford, British Columbia, Canada

Site Status

BC Cancer Victoria ( Site 0513)

Victoria, British Columbia, Canada

Site Status

Kingston Health Sciences Centre-Kingston General Hospital Si-Oncology and/or Hematology - Gynecolog

Kingston, Ontario, Canada

Site Status

Sunnybrook Health Sciences - Odette Cancer Centre ( Site 0508)

Toronto, Ontario, Canada

Site Status

CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 0501)

Montreal, Quebec, Canada

Site Status

Jewish General Hospital ( Site 0505)

Montreal, Quebec, Canada

Site Status

McGill University Health Centre ( Site 0502)

Montreal, Quebec, Canada

Site Status

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0

Québec, Quebec, Canada

Site Status

Saskatoon Cancer Center ( Site 0510)

Saskatoon, Saskatchewan, Canada

Site Status

Clínica Puerto Montt ( Site 0601)

Port Montt, Los Lagos Region, Chile

Site Status

Oncovida ( Site 0603)

Santiago, Region M. de Santiago, Chile

Site Status

Instituto de Radiomedicina-hemato-oncologia ( Site 0604)

Santiago, Region M. de Santiago, Chile

Site Status

Clínica Vespucio-Hemato - Ocology ( Site 0607)

Santiago, Region M. de Santiago, Chile

Site Status

Pontificia Universidad Catolica de Chile-Centro del Cáncer ( Site 0609)

Santiago, Region M. de Santiago, Chile

Site Status

Bradfordhill ( Site 0605)

Santiago, Region M. de Santiago, Chile

Site Status

James Lind Centro de Investigación del Cáncer ( Site 0602)

Temuco, Región de la Araucanía, Chile

Site Status

CIDO SpA-Oncology ( Site 0608)

Temuco, Región de la Araucanía, Chile

Site Status

Anhui Provincial Hospital-Obstetrics and Gynecology ( Site 0709)

Hefei, Anhui, China

Site Status

Beijing Cancer hospital ( Site 0711)

Beijing, Beijing Municipality, China

Site Status

Beijing Peking Union Medical College Hospital-Gynecological center of tumor ( Site 0702)

Beijing, Beijing Municipality, China

Site Status

Fujian Provincial Cancer Hospital ( Site 0713)

Fuzhou, Fujian, China

Site Status

Lanzhou university second hospital ( Site 0734)

Lanzhou, Gansu, China

Site Status

Zhujiang Hospital ( Site 0739)

Guangzhou, Guangdong, China

Site Status

Affiliated Hospital of Guangdong Medical University ( Site 0743)

Zhanjiang, Guangdong, China

Site Status

Guangxi Medical University Affiliated Tumor Hospital ( Site 0717)

Nanning, Guangxi, China

Site Status

Hainan General Hospital ( Site 0736)

Haikou, Hainan, China

Site Status

Henan Cancer Hospital ( Site 0718)

Zhengzhou, Henan, China

Site Status

Wuhan Union Hospital-Medical Oncology ( Site 0735)

Wuhan, Hubei, China

Site Status

Hubei Cancer Hospital-Hubei Cancer Hospital ( Site 0708)

Wuhan, Hubei, China

Site Status

Xiangya Hospital Central South University-Gynecology ( Site 0705)

Changsha, Hunan, China

Site Status

Hunan Cancer Hospital ( Site 0704)

Changsha, Hunan, China

Site Status

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Oncology (

Nanjing, Jiangsu, China

Site Status

Zhongda Hospital Southeast University ( Site 0723)

Nanjing, Jiangsu, China

Site Status

Jiangxi Maternal and Child Health Hospital-Oncology Department ( Site 0716)

Nanchang, Jiangxi, China

Site Status

The First Hospital of Jilin University ( Site 0710)

Changchun, Jilin, China

Site Status

Shandong Cancer Hospital-Oncology Department ( Site 0733)

Jinan, Shandong, China

Site Status

LinYi Cancer Hospital ( Site 0731)

Linyi, Shandong, China

Site Status

Obstetrics & Gynecology Hospital of Fudan University ( Site 0715)

Shanghai, Shanghai Municipality, China

Site Status

Fudan University Shanghai Cancer Center-Gynecologic Oncology Department ( Site 0701)

Shanghai, Shanghai Municipality, China

Site Status

Shanghai First Maternity and Infant Hospital-Gynecology department ( Site 0744)

Shanghai, Shanghai Municipality, China

Site Status

West China Second University Hospital Sichuan University ( Site 0740)

Chengdu, Sichuan, China

Site Status

Tianjin Central Hosptial of Gynecology Obstetrics ( Site 0737)

Tianjin, Tianjin Municipality, China

Site Status

Tianjin Medical University Cancer Institute and Hospital ( Site 0720)

Tianjin, Tianjin Municipality, China

Site Status

Yunnan Province Cancer Hospital-Gynecology Department ( Site 0714)

Kunming, Yunnan, China

Site Status

The Affiliated Women's Hospital of Zhejiang University-Obstetrics and Gynecology ( Site 0741)

Hangzhou, Zhejiang, China

Site Status

The First Affiliated Hospital of Wenzhou Medical University-Gynecology ( Site 0706)

Wenzhou, Zhejiang, China

Site Status

Fundación Colombiana de Cancerología Clínica Vida ( Site 0808)

Medellín, Antioquia, Colombia

Site Status

Clinica de la Costa LTDA-Clinical Research Oncology & Hematology -Pediatric ( Site 0809)

Barranquilla, Atlántico, Colombia

Site Status

Clínica Universitaria Colombia ( Site 0806)

Bogotá, Bogota D.C., Colombia

Site Status

Oncologos del Occidente ( Site 0807)

Pereira, Risaralda Department, Colombia

Site Status

Hemato Oncologos SA ( Site 0801)

Cali, Valle del Cauca Department, Colombia

Site Status

Aalborg Universitetshospital, Syd ( Site 0901)

Aalborg, North Denmark, Denmark

Site Status

Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1001)

Turku, Southwest Finland, Finland

Site Status

Centre Hospitalier Régional Universitaire de Brest - Hôpital-Institut de cancérologie et hématologi

Brest, Brittany Region, France

Site Status

Centre François Baclesse-Recherche clinique ( Site 2904)

Caen, Calvados, France

Site Status

Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren-oncologie ( Site 2907)

Limoges, Haute-Vienne, France

Site Status

Institut Curie - site Saint-Cloud ( Site 2909)

Saint-Cloud, Hauts-de-Seine, France

Site Status

Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer-Medical Oncology ( Site 2901)

Rennes, Ille-et-Vilaine, France

Site Status

Centre de Cancérologie du Grand Montpellier ( Site 2908)

Montpellier, Languedoc-Roussillon, France

Site Status

Hôpital privé du Confluent SAS-Service d'oncologie médicale ( Site 2905)

Nantes, Loire-Atlantique, France

Site Status

Universitaetsklinikum Erlangen-Klinik für Gynäkologie und Geburtshilfe ( Site 1205)

Erlangen, Bavaria, Germany

Site Status

Universitätsklinikum Bonn-Gynaecological oncology ( Site 1203)

Bonn, North Rhine-Westphalia, Germany

Site Status

Universitaetsklinikum Duesseldorf-Klinik für Frauenheilkunde & Geburtshilfe ( Site 1204)

Düsseldorf, North Rhine-Westphalia, Germany

Site Status

Zentrum fuer ambulante gynaekologische Onkologie (ZAGO) ( Site 1207)

Krefeld, North Rhine-Westphalia, Germany

Site Status

CaritasKlinikum Saarbrücken St. Theresia ( Site 1211)

Saarbrücken, Saarland, Germany

Site Status

Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Frauenheilkunde und Gebur

Dresden, Saxony, Germany

Site Status

Universitätsklinikum Leipzig-Department of Gynecology and Obstetrics ( Site 1213)

Leipzig, Saxony, Germany

Site Status

Charité Campus Virchow-Klinikum ( Site 1201)

Berlin, , Germany

Site Status

Asklepios Kliniken Hamburg-Asklepios Klinik Barmbek ( Site 1214)

Hamburg, , Germany

Site Status

St. James's Hospital-Cancer clinical trials office ( Site 2821)

Dublin, , Ireland

Site Status

Emek Medical Center-Gyn-Onc ( Site 1406)

Afula, , Israel

Site Status

Soroka Medical Center ( Site 1404)

Beersheba, , Israel

Site Status

Rambam Health Care Campus-Gyneco-oncology unit ( Site 1402)

Haifa, , Israel

Site Status

Shaare Zedek Medical Center ( Site 1405)

Jerusalem, , Israel

Site Status

Rabin Medical Center ( Site 1401)

Petah Tikva, , Israel

Site Status

Sheba Medical Center ( Site 1407)

Ramat Gan, , Israel

Site Status

Sourasky Medical Center ( Site 1403)

Tel Aviv, , Israel

Site Status

IRCCS - AOU di Bologna-SSD Oncologia medica Addarii ( Site 1501)

Bologna, Emilia-Romagna, Italy

Site Status

Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1503)

Milan, Lombardy, Italy

Site Status

Ospedale San Gerardo-ASST Monza-Oncologia ( Site 1508)

Monza, Lombardy, Italy

Site Status

ASST Grande Ospedale Metropolitano Niguarda ( Site 1505)

Milan, Milano, Italy

Site Status

Ospedale Mauriziano-Ginecologia e Ostetricia ( Site 1507)

Turin, Piedmont, Italy

Site Status

Azienda Ospedaliera Spedali Civili di Brescia ( Site 1504)

Brescia, , Italy

Site Status

Istituto Europeo di Oncologia IRCCS-Divisione di Ginecologia Oncologica ( Site 1502)

Milan, , Italy

Site Status

Aichi Cancer Center Hospital ( Site 1610)

Nagoya, Aichi-ken, Japan

Site Status

National Cancer Center Hospital East ( Site 1609)

Kashiwa, Chiba, Japan

Site Status

National Hospital Organization Shikoku Cancer Center ( Site 1603)

Matsuyama, Ehime, Japan

Site Status

Ehime University Hospital ( Site 1606)

Tōon, Ehime, Japan

Site Status

Kurume University Hospital ( Site 1607)

Kurume, Fukuoka, Japan

Site Status

Hokkaido University Hospital ( Site 1604)

Sapporo, Hokkaido, Japan

Site Status

Iwate Medical University Hospital ( Site 1613)

Shiwa-gun Yahaba-cho, Iwate, Japan

Site Status

Nippon Medical School Musashi Kosugi Hospital ( Site 1614)

Kawasaki, Kanagawa, Japan

Site Status

Saitama Medical University International Medical Center ( Site 1601)

Hidaka-shi, Saitama, Japan

Site Status

Shizuoka Cancer Center ( Site 1611)

Nakatogari, Shizuoka, Japan

Site Status

National Cancer Center Hospital ( Site 1612)

Chuo-ku, Tokyo, Japan

Site Status

Japanese Foundation for Cancer Research ( Site 1605)

Koto, Tokyo, Japan

Site Status

Osaka International Cancer Institute ( Site 1602)

Osaka, , Japan

Site Status

Investigación Oncofarmacéutica-Investigación clínica ( Site 1706)

La Paz, Baja California Sur, Mexico

Site Status

COI Centro Oncologico Internacional S.A.P.I. de C.V.-Investigation Unit COI ( Site 1703)

Mexico City, Mexico City, Mexico

Site Status

INSTITUTO NACIONAL DE CANCEROLOGIA ( Site 1701)

Mexico City, Mexico City, Mexico

Site Status

iCan Oncology Center Centro Medico AVE ( Site 1704)

Monterrey, Nuevo León, Mexico

Site Status

Centro de Investigacion Clinica de Oaxaca ( Site 1705)

Oaxaca City, , Mexico

Site Status

Radboudumc ( Site 1802)

Nijmegen, Gelderland, Netherlands

Site Status

Leids Universitair Medisch Centrum-Medical Oncology ( Site 1801)

Leiden, South Holland, Netherlands

Site Status

Erasmus Medisch Centrum-Medical Oncology ( Site 1803)

Rotterdam, South Holland, Netherlands

Site Status

Universitair Medisch Centrum Utrecht-Medical Oncology ( Site 1804)

Utrecht, , Netherlands

Site Status

Auckland City Hospital ( Site 1901)

Auckland, , New Zealand

Site Status

Universitetssykehuset Nord-Norge HF-Kreftavdelingen ( Site 2001)

Tromsø, Troms, Norway

Site Status

Szpital Kliniczny im. Heliodora Święcickiego Uniwersytetu Me-Oddzial Ginekologii Onkologicznej ( Sit

Poznan, Greater Poland Voivodeship, Poland

Site Status

Szpital Kliniczny im. Księżnej Anny Mazowieckiej ( Site 2103)

Warsaw, Masovian Voivodeship, Poland

Site Status

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Gynecological Oncology Department ( Sit

Warsaw, Masovian Voivodeship, Poland

Site Status

Bialostockie Centrum Onkologii-Oddzial Onkologii Ginekologicznej ( Site 2106)

Bialystok, Podlaskie Voivodeship, Poland

Site Status

Uniwersytecki Szpital Kliniczny w Bialymstoku-Uniwersyteckie Centrum Onkologii ( Site 2104)

Bialystok, Podlaskie Voivodeship, Poland

Site Status

Uniwersyteckie Centrum Kliniczne-Klinika Ginekologii, Ginekologii Onkologicznej i Endokrynologii Gi

Gdansk, Pomeranian Voivodeship, Poland

Site Status

Narodowy Instytut Onkologii - Oddzial w Gliwicach-III Klinika Radioterapii i Chemioterapii ( Site 21

Gliwice, Silesian Voivodeship, Poland

Site Status

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej ( Site 2107)

Kielce, Świętokrzyskie Voivodeship, Poland

Site Status

Chelyabinsk Regional Clinical Oncology Dispensary-Chelyabinsk Regional Clinical Oncology Dispensary

Chelyabinsk, Chelyabinsk Oblast, Russia

Site Status

Ogarev Mordovia State University ( Site 2209)

Saransk, Mordoviya, Respublika, Russia

Site Status

Fed State Budgetary Inst "N.N. Blokhin Med Center of Oncology" MHRF-Chemotherapy #2 ( Site 2211)

Moscow, Moscow, Russia

Site Status

Moscow City Oncology Hospital #62 ( Site 2214)

Krasnogorsk D-t, Moscow Oblast, Russia

Site Status

SVERDLOVSK REGIONAL ONCOLOGY DISPENSARY-Oncogynecology Department ( Site 2216)

Yekaterinburg, Sverdlovsk Oblast, Russia

Site Status

Seoul National University Hospital ( Site 2302)

Seoul, , South Korea

Site Status

Severance Hospital, Yonsei University Health System-Gynecologic cancer center ( Site 2303)

Seoul, , South Korea

Site Status

Asan Medical Center-Division of Gynecologic Oncology, Dept. of Obstetrics & Gynecology ( Site 2304)

Seoul, , South Korea

Site Status

Gangnam Severance Hospital ( Site 2301)

Seoul, , South Korea

Site Status

cukurova universty ( Site 2706)

Sarçam, Adana, Turkey (Türkiye)

Site Status

Istanbul Universitesi Cerrahpasa ( Site 2709)

Fatih, Istanbul, Turkey (Türkiye)

Site Status

Ege University Medicine of Faculty ( Site 2702)

Bornova, İzmir, Turkey (Türkiye)

Site Status

Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 2704)

Adana, , Turkey (Türkiye)

Site Status

Ankara University Hospital Cebeci ( Site 2701)

Ankara, , Turkey (Türkiye)

Site Status

Baskent Universitesi Ankara Hastanesi ( Site 2707)

Ankara, , Turkey (Türkiye)

Site Status

Bezmialem Vakf Üniversitesi-Oncology ( Site 2705)

Istanbul, , Turkey (Türkiye)

Site Status

T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma

Istanbul, , Turkey (Türkiye)

Site Status

Brighton and Sussex University Hospitals NHS Trust ( Site 2803)

East Sussex, Brighton And Hove, United Kingdom

Site Status

Addenbrooke's Hospital ( Site 2808)

Cambridge, Cambridgeshire, United Kingdom

Site Status

The Royal Cornwall Hospital ( Site 2804)

Truro, Cornwall, United Kingdom

Site Status

Westmorland General Hospital ( Site 2815)

Kendal, Cumbria, United Kingdom

Site Status

Ninewells Hospital and Medical School ( Site 2826)

Dundee, Dundee City, United Kingdom

Site Status

Leicester Royal Infirmary-HOPE Clinical Trials Unit ( Site 2812)

Leicester, England, United Kingdom

Site Status

Hammersmith Hospital-Medical Oncology ( Site 2818)

London, London, City of, United Kingdom

Site Status

Velindre Cancer Centre ( Site 2805)

Cardiff, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Australia Belgium Brazil Canada Chile China Colombia Denmark Finland France Germany Ireland Israel Italy Japan Mexico Netherlands New Zealand Norway Poland Russia South Korea Turkey (Türkiye) United Kingdom

References

Explore related publications, articles, or registry entries linked to this study.

Gaitskell K, Rogozinska E, Platt S, Chen Y, Abd El Aziz M, Tattersall A, Morrison J. Angiogenesis inhibitors for the treatment of epithelial ovarian cancer. Cochrane Database Syst Rev. 2023 Apr 18;4(4):CD007930. doi: 10.1002/14651858.CD007930.pub3.

Reference Type DERIVED
PMID: 37185961 (View on PubMed)

Related Links

Access external resources that provide additional context or updates about the study.

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

MK-3475-B96

Identifier Type: OTHER

Identifier Source: secondary_id

KEYNOTE-B96

Identifier Type: OTHER

Identifier Source: secondary_id

ENGOT-ov65

Identifier Type: OTHER

Identifier Source: secondary_id

jRCT2051210184

Identifier Type: REGISTRY

Identifier Source: secondary_id

2023-506177-35-00

Identifier Type: REGISTRY

Identifier Source: secondary_id

U1111-1287-5318

Identifier Type: REGISTRY

Identifier Source: secondary_id

2020-005027-37

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

3475-B96

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.