Sleep Disorders in Idiopathic Pulmonary Fibrosis

NCT ID: NCT05113654

Last Updated: 2021-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

78 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-04-26

Study Completion Date

2019-06-07

Brief Summary

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This diagnostic observational study was conducted to (1) investigate the prevalence of sleep-related breathing disorders and other sleep disorders in idiopathic pulmonary fibrosis in comparison to COPD, (2) identify characteristics of symptomatic and prognostic significance in idiopathic pulmonary fibrosis with/without sleep disorders, and (3) evaluate different tools for their ability to assess the risk of co-existing sleep disorders in idiopathic pulmonary fibrosis.

Detailed Description

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Conditions

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Idiopathic Pulmonary Fibrosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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IPF

Patients with idiopathic pulmonary fibrosis

Sleep study

Intervention Type DIAGNOSTIC_TEST

Nocturnal polysomnography or polygraphy to assess sleep-related breathing disorder and other sleep disorders

COPD

Patients with chronic obstructive pulmonary disease

Sleep study

Intervention Type DIAGNOSTIC_TEST

Nocturnal polysomnography or polygraphy to assess sleep-related breathing disorder and other sleep disorders

Healthy

Healthy controls

Sleep study

Intervention Type DIAGNOSTIC_TEST

Nocturnal polysomnography or polygraphy to assess sleep-related breathing disorder and other sleep disorders

Interventions

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Sleep study

Nocturnal polysomnography or polygraphy to assess sleep-related breathing disorder and other sleep disorders

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Age \>=18 years
* written informed consent
* IPF cohort: Documented history of IPF with definite or possible UIP pattern and signs of emphysema below 10% by HRCT (IPF diagnosis according to 2011 ATS/ERS IPF guidelines)
* COPD cohort: Documented history of COPD Stage II Group A or B, Stage III or IV, Group C or D (GOLD 2014)

Exclusion Criteria

* Long-term oxygen therapy
* Heart failure NYHA stages III and IV
* Left ventricular ejection fraction ≤ 45%
* Pregnancy and/or lactation
* Acute and/or life-threatening illness (instable angina pectoris, acute pulmonary arterial embolism, myocardial infarction, malignant tumor requiring treatment)
* Current drug or alcohol abuse
* Any medical, psychological or other condition impairing the patient's ability to provide informed consent
* IPF cohort: Acute exacerbation of IPF
* IPF cohort: Concomitant lung/airway diseases other than IPF (signs of emphysema \>10% by HRCT)
* COPD cohort: Acute exacerbation of COPD
* COPD cohort: Concomitant lung/airway diseases other than COPD (e.g. Asthma bronchiale)
* Healthy cohort: Documented history of structural airway or lung disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role collaborator

Wissenschaftliches Institut Bethanien e.V

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Winfried Randerath, Prof. Dr.

Role: PRINCIPAL_INVESTIGATOR

Wissenschaftliches Institut Bethanien e.V

Locations

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Wissenschaftliches Institut Bethanien e.V.

Solingen, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

Other Identifiers

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WI_SleepIPF_169/2015

Identifier Type: -

Identifier Source: org_study_id