PK and Safety of SCT510

NCT ID: NCT05113511

Last Updated: 2021-11-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 84 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-05-09
• Study Completion Date: 2021-07-26

Brief Summary

This is a randomized, double-blind, parallel-controlled phase I clinical study comparing the pharmacokinetics, safety and immunogenicity of SCT510 with bevacizumab (Avastin®) in Chinese healthy males.

Detailed Description

Eighty-four subjects randomly (1:1) received a 3 mg/kg dose of SCT510 or bevacizumab infusion for 90 min and followed up for 99 days. The screening period of this study is 14 days. Subjects will be admitted to the research center on day-1 and will be allowed to leave the research center with relevant observation and evaluation on day 5 (96 hours) after the completion of the administration. Subjects were asked to return for 10 follow-up visits respectively according to this research protocol, on the day 8, day 15, day 22, day 29, day 43, day 57, day 64, day 71, day 85 and day 99.

All subjects in each group will be blinded after blood/urine collection and safety evaluation.

Blood samples will be tested by a validated LC/MS method for pharmacokinetic study.

Conditions

Healthy

Keywords

pharmacokinetics; immunogenicity; biosimilar; phase I; anti-VEGF monoclonal antibody

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

SCT510

SCT510

Group Type: EXPERIMENTAL

SCT510

Intervention Type: DRUG

Subjects received a single intravenous infusion (3 mg/kg) of SCT510 for 90 minutes , and the volume of administration was calculated based on the subject's weight.

bevacizumab

bevacizumab

Group Type: ACTIVE_COMPARATOR

Bevacizumab

Intervention Type: DRUG

Subjects received a single intravenous infusion (3 mg/kg) of bevacizumab for 90 minutes , and the volume of administration was calculated based on the subject's weight.

Interventions

SCT510

Subjects received a single intravenous infusion (3 mg/kg) of SCT510 for 90 minutes , and the volume of administration was calculated based on the subject's weight.

Intervention Type: DRUG

Bevacizumab

Subjects received a single intravenous infusion (3 mg/kg) of bevacizumab for 90 minutes , and the volume of administration was calculated based on the subject's weight.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Healthy volunteers who fully understand the purpose, content, benefits and possible adverse reactions of the test and voluntarily sign written informed consent prior to the commencement of any test-related activities.

2. Healthy males, aged 18 to 45 years (including 18 and 45 years).

3. Male subjects weighed 45-100 kg (including 45 and 100 kg), body mass index (BMI) was 19.0-25.0 kg/m2 (including 19.0 and 25.0 kg/m2), where BMI = body weight (kg)/height2 (m2).

4. The subject agrees to use reliable contraceptive methods (such as abstinence, sterilization, birth control pills, injectable contraceptive meprogesterone or subcutaneous implantation) for himself and his partner during the study period and for 6 months after the infusion of study drugs.

Exclusion Criteria

1. History of hypertension or abnormal blood pressure at screening/baseline [SBP >140 mmHg and/or diastolic blood pressure >90 mmHg confirmed by one repeat measurement on the same day];

2. Clinically significant proteinuria examination or history of proteinuria assessed by the investigator;

3. Abnormal physical examination or examination results (e.g., chest X-ray, laboratory examination) are considered clinically significant by the investigator;

4. Have received any antibody or protein drug or small molecule targeted drug therapy targeting VEGF or VEGF receptor in the past 1 year;

5. Use of any biological product or live viral vaccine within 3 months prior to drug infusion, or use of any monoclonal antibody within 12 months;

6. Have hereditary bleeding tendency or coagulopathy, or have a history of thrombosis or bleeding;

7. History of digestive tract perforation or fistula;

8. Unhealed wounds, ulcers or fractures, or those who had undergone major surgery within the previous 2 months or were expected to undergo major surgery within the study period or 2 months after the end of the study;

9. Use a prescription or over-the-counter drug or nutraceutical product within the 5 half-life of the drug or nutraceutical product or within 2 weeks prior to use of the study drug, whichever is longer. Herbal supplements should be discontinued 28 days prior to use of the study drug;

10. Hepatitis B virus surface antigen (HBsAg), hepatitis C virus (HCV) antibody, human immunodeficiency virus (HIV) antibody, or treponema pallidum antibody test positive;

11. Known allergy to bevacizumab or any of its excipients;

12. Known history of allergic diseases or allergies;

13. People with a history of severe allergy, allergy to protein products, rat-derived products and related ingredients of experimental drugs;

14. Blood donation history within 3 months prior to drug infusion;

15. Has received any other investigational drug treatment or participated in another interventional clinical trial within 3 months prior to screening;

16. History of alcohol or drug abuse in the 12 months prior to screening; Subjects were unable to abstain from alcohol within 72 hours prior to administration and throughout the trial;

17. A history of mental illness;

18. Have pregnancy plans during the trial ;

19. Unable to complete the study according to protocol requirements during the study;

20. Conditions considered unsuitable for inclusion by other researchers.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Sinocelltech Ltd.

INDUSTRY

Sponsor Role: collaborator

First Affiliated Hospital of Zhejiang University

OTHER

Sponsor Role: lead

Responsible Party

shentu jianzhong

Ph.D.(Pharm）

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

First Affiliated Hospital of Zhejiang University

Hangzhou, Zhejiang, China

Countries

China

References

Wu J, Wu G, Xie L, Lv D, Xu C, Zhou H, Wu L, Zhang J, Shentu J. A Randomized, Double-Blind, Parallel-Controlled Phase I Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of SCT510 to Bevacizumab (Avastin(R)) in Healthy Chinese Males. Drugs R D. 2023 Jun;23(2):175-183. doi: 10.1007/s40268-023-00424-8. Epub 2023 May 29.

Reference Type: DERIVED

PMID: 37247166 (View on PubMed)

Other Identifiers

SCT510NSCLC01

Identifier Type: -

Identifier Source: org_study_id