Preliminary Study on the Clinical Effect of Recombinant Human Brain Natriuretic Peptide on Sepsis Complicated With Heart Failure
NCT ID: NCT05111769
Last Updated: 2021-11-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
70 participants
INTERVENTIONAL
2021-12-01
2023-12-01
Brief Summary
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Detailed Description
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Recombinant human brain natriuretic peptide (rhBNP) was approved by FDA in 2001 for the treatment of acute decompensated heart failure.These effects play a role in the protection of cardiac and kidney function, and have achieved good results in patients with cardiac insufficiency and AKI caused by cardiac surgery.
The investigators are going to carry out related research from the following aspects: 1. To determine the effect of rhBNP on hemodynamics in sepsis based on PiCCO hemodynamic monitoring; 2. To collect and sort out the relevant data to determine the effects of rhBNP on cardiac function and kidney function, including cardiac ultrasound, kidney blood flow index and related laboratory tests. 3. To determine the effect of rhBNP on the final prognosis of patients, including ICU mortality and hospital mortality, ICU time, hospital stay, ventilator use time, kidney replacement therapy time, vasoactive drug dosage and time.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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rhBNP in the treatment of sepsis complicated with heart failure
Recombinant human brain natriuretic peptide (rhBNP) on sepsis complicated with heart failure
Recombinant human brain natriuretic peptide
1\. To determine the effect of rhBNP on hemodynamics in sepsis based on PiCCO hemodynamic monitoring; 2. To collect and sort out the relevant data to determine the effects of rhBNP on cardiac function and kidney function, including cardiac ultrasound, kidney blood flow index and related laboratory tests. 3. To determine the effect of rhBNP on the final prognosis of patients, including ICU mortality and hospital mortality, ICU time, hospital stay, ventilator use time, kidney replacement therapy time, vasoactive drug dosage and time.
Conventional treatment group
Do not use recombinant human brain natriuretic peptide (rhBNP) to treat sepsis with heart failure
No interventions assigned to this group
Interventions
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Recombinant human brain natriuretic peptide
1\. To determine the effect of rhBNP on hemodynamics in sepsis based on PiCCO hemodynamic monitoring; 2. To collect and sort out the relevant data to determine the effects of rhBNP on cardiac function and kidney function, including cardiac ultrasound, kidney blood flow index and related laboratory tests. 3. To determine the effect of rhBNP on the final prognosis of patients, including ICU mortality and hospital mortality, ICU time, hospital stay, ventilator use time, kidney replacement therapy time, vasoactive drug dosage and time.
Eligibility Criteria
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Inclusion Criteria
* Heart failure: BNP rises by 600 pg/ml
* Age\>=18 years old
Exclusion Criteria
* Pregnant
* Disagree with comprehensive and active life support treatment
* coronary heart disease, myocardial infarction, and cardiac insufficiency
* chronic renal insufficiency
18 Years
80 Years
ALL
Yes
Sponsors
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Shanghai Zhongshan Hospital
OTHER
Responsible Party
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Locations
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Ju Minjie
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Other Identifiers
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SEPSIS-HF
Identifier Type: -
Identifier Source: org_study_id