Trial Outcomes & Findings for Crowdsourcing to Reduce HIV Stigma Among Adolescents and Young Adults in Kazakhstan (NCT NCT05107401)
NCT ID: NCT05107401
Last Updated: 2024-12-17
Results Overview
The scale/questionnaire is comprised of 17 items on a 5-point Likert scale (score range from 17-85). Higher scores indicate higher levels of stigma. Outcome will be assessed in mean score change from baseline to 3 months follow-up.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
216 participants
Primary outcome timeframe
Baseline and 3 months
Results posted on
2024-12-17
Participant Flow
Adolescents and young adults were recruited online via websites and social media advertisements and in-person at youth events in Almaty, Kazakhstan from January to August 2023. Those who were interested in study participation completed an online screening survey.
Participant milestones
| Measure |
Crowdsourced Intervention
The digital crowdsourced intervention developed by adolescents and young adults will be presented to participants in the intervention arm.
|
Standard of Care
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
|---|---|---|
|
Overall Study
STARTED
|
111
|
105
|
|
Overall Study
COMPLETED
|
98
|
93
|
|
Overall Study
NOT COMPLETED
|
13
|
12
|
Reasons for withdrawal
| Measure |
Crowdsourced Intervention
The digital crowdsourced intervention developed by adolescents and young adults will be presented to participants in the intervention arm.
|
Standard of Care
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
|---|---|---|
|
Overall Study
Lost to Follow-up
|
13
|
12
|
Baseline Characteristics
Crowdsourcing to Reduce HIV Stigma Among Adolescents and Young Adults in Kazakhstan
Baseline characteristics by cohort
| Measure |
Crowdsourced Intervention
n=111 Participants
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Standard of Care
n=105 Participants
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
Total
n=216 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
20.1 years
STANDARD_DEVIATION 2.4 • n=5 Participants
|
19.4 years
STANDARD_DEVIATION 2.4 • n=7 Participants
|
19.7 years
STANDARD_DEVIATION 2.4 • n=5 Participants
|
|
Sex: Female, Male
Female
|
65 Participants
n=5 Participants
|
51 Participants
n=7 Participants
|
116 Participants
n=5 Participants
|
|
Sex: Female, Male
Male
|
46 Participants
n=5 Participants
|
54 Participants
n=7 Participants
|
100 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Ethnicity · Kazakh
|
58 Participants
n=5 Participants
|
63 Participants
n=7 Participants
|
121 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Ethnicity · Russian
|
37 Participants
n=5 Participants
|
28 Participants
n=7 Participants
|
65 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Ethnicity · Other
|
16 Participants
n=5 Participants
|
14 Participants
n=7 Participants
|
30 Participants
n=5 Participants
|
|
Region of Enrollment
Kazakhstan
|
111 participants
n=5 Participants
|
105 participants
n=7 Participants
|
216 participants
n=5 Participants
|
|
Sexual Orientation
Heterosexual
|
89 Participants
n=5 Participants
|
77 Participants
n=7 Participants
|
166 Participants
n=5 Participants
|
|
Sexual Orientation
Sexual Minority
|
22 Participants
n=5 Participants
|
28 Participants
n=7 Participants
|
50 Participants
n=5 Participants
|
PRIMARY outcome
Timeframe: Baseline and 3 monthsThe scale/questionnaire is comprised of 17 items on a 5-point Likert scale (score range from 17-85). Higher scores indicate higher levels of stigma. Outcome will be assessed in mean score change from baseline to 3 months follow-up.
Outcome measures
| Measure |
Crowdsourced Intervention
n=98 Participants
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Standard of Care
n=93 Participants
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
Males - Crowdsourced Intervention
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Males - Standard of Care
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
|---|---|---|---|---|
|
Mean Score Change in Total HIV Stigma Scale
Baseline
|
47.48 units on a scale
Standard Error 0.71
|
47.89 units on a scale
Standard Error 0.74
|
—
|
—
|
|
Mean Score Change in Total HIV Stigma Scale
3 month follow-up
|
44.60 units on a scale
Standard Error 0.75
|
47.32 units on a scale
Standard Error 0.79
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline and 3 monthsThis is a subscale of the Total HIV Stigma scale. It contains 2 items, each on a 1-5 point Likert scale, with a range of 5-10. Higher values indicate higher levels of HIV stigma.
Outcome measures
| Measure |
Crowdsourced Intervention
n=98 Participants
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Standard of Care
n=93 Participants
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
Males - Crowdsourced Intervention
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Males - Standard of Care
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
|---|---|---|---|---|
|
Mean Change in Perceived HIV Test Stigma
Baseline
|
5.92 units on a scale
Standard Error 0.13
|
5.70 units on a scale
Standard Error 0.14
|
—
|
—
|
|
Mean Change in Perceived HIV Test Stigma
3 months
|
5.19 units on a scale
Standard Error 0.14
|
5.64 units on a scale
Standard Error 0.14
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline and 3 monthsThis is a subscale of the Total HIV Stigma Scale. It contains two items, each on a 1-5 point Likert scale, with a range of 5-10. Higher values indicate higher levels of HIV healthcare stigma.
Outcome measures
| Measure |
Crowdsourced Intervention
n=98 Participants
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Standard of Care
n=93 Participants
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
Males - Crowdsourced Intervention
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Males - Standard of Care
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
|---|---|---|---|---|
|
Mean Change in Perceived HIV Healthcare Stigma Subscale
Baseline
|
5.80 units on a scale
Standard Error 0.14
|
5.90 units on a scale
Standard Error 0.15
|
—
|
—
|
|
Mean Change in Perceived HIV Healthcare Stigma Subscale
3 months follow-up
|
5.57 units on a scale
Standard Error 0.15
|
5.89 units on a scale
Standard Error 0.16
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline and 3 monthsThis is a subscale of the Total HIV Stigma Scale. It consists of 5 items, each on a 1-5 point Likert scale, with a range of 5-25. Higher values indicate higher levels of fear \& judgement HIV stigma.
Outcome measures
| Measure |
Crowdsourced Intervention
n=98 Participants
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Standard of Care
n=93 Participants
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
Males - Crowdsourced Intervention
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Males - Standard of Care
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
|---|---|---|---|---|
|
Mean Change in Fear & Judgement HIV Stigma Sub-scale
3 months follow-up
|
10.56 units on a scale
Standard Error 0.36
|
11.08 units on a scale
Standard Error 0.38
|
—
|
—
|
|
Mean Change in Fear & Judgement HIV Stigma Sub-scale
Baseline
|
11.12 units on a scale
Standard Error 0.35
|
11.24 units on a scale
Standard Error 0.36
|
—
|
—
|
SECONDARY outcome
Timeframe: Baseline and 3 monthsThis is a subscale of the Total HIV Stigma Scale. It consists of 8 items, each on a 1-5 point Likert-scale, with a range of 6-40. Higher values indicate higher levels of perceived community HIV stigma.
Outcome measures
| Measure |
Crowdsourced Intervention
n=98 Participants
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Standard of Care
n=93 Participants
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
Males - Crowdsourced Intervention
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Males - Standard of Care
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
|---|---|---|---|---|
|
Mean Change in Perceived Community HIV Stigma Subscale
Baseline
|
24.65 units on a scale
Standard Error 0.45
|
25.05 units on a scale
Standard Error 0.47
|
—
|
—
|
|
Mean Change in Perceived Community HIV Stigma Subscale
3 month follow-up
|
23.28 units on a scale
Standard Error 0.47
|
24.74 units on a scale
Standard Error 0.50
|
—
|
—
|
SECONDARY outcome
Timeframe: After baseline and by the 3 month follow-up periodThe number of participants who ordered an HIV self-test kit after baseline and by the 3-month follow-up. It is a dichotomous outcome (yes/no).
Outcome measures
| Measure |
Crowdsourced Intervention
n=98 Participants
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Standard of Care
n=93 Participants
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
Males - Crowdsourced Intervention
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Males - Standard of Care
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
|---|---|---|---|---|
|
Uptake of HIV Self-test
|
30 Participants
|
18 Participants
|
—
|
—
|
POST_HOC outcome
Timeframe: Baseline and 3 monthsThe Total HIV Stigma scale consists of 17 items, each on a 1-5 point Likert scale, with a range of 17-85. Higher values indicate higher levels of HIV stigma.
Outcome measures
| Measure |
Crowdsourced Intervention
n=65 Participants
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Standard of Care
n=51 Participants
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
Males - Crowdsourced Intervention
n=46 Participants
The digital crowdsourced intervention will be presented to participants in the intervention arm.
Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
|
Males - Standard of Care
n=54 Participants
Standard HIV informational materials currently used by the Kazakhstan Ministry of Health will be presented to participants in the control arm.
|
|---|---|---|---|---|
|
Subgroup Analyses By Sex of Mean Change in Total HIV Stigma Scale
Baseline
|
47.55 units on a scale
Standard Error 0.91
|
48.24 units on a scale
Standard Error 1.06
|
47.44 units on a scale
Standard Error 1.09
|
47.63 units on a scale
Standard Error 1.02
|
|
Subgroup Analyses By Sex of Mean Change in Total HIV Stigma Scale
3 months follow-up
|
42.39 units on a scale
Standard Error 0.96
|
48.17 units on a scale
Standard Error 1.09
|
47.80 units on a scale
Standard Error 1.16
|
46.41 units on a scale
Standard Error 1.12
|
Adverse Events
Crowdsourced Intervention
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Standard of Care
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place