Effect of PPCI on Diastolic Function & Levels of Galactin-3 in Patients With STEMI
NCT ID: NCT05107076
Last Updated: 2021-11-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
80 participants
OBSERVATIONAL
2021-11-30
2023-05-31
Brief Summary
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* Peripheral blood samples were obtained within 48 hours after acute MI, and the serum will be frozen at -70°C until tested for Galactin-3 level.
* Follow up 2D Doppler echocardiography:
will be repeated at 40 days of the event.
Detailed Description
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It will be done within 24 h after PPCI. Measurements will be as following:
1. Pulsed wave (PW) Doppler will be performed in the apical 4chamber view within a 3 mm sample volume at the tip of the mitral leaflets to obtain mitral inflow velocities to assess LV filling.
2. E (early diastolic)/A (late diastolic) - Using PW Doppler, the peak E and A velocities were recorded, then the ratio of E/A will be calculated.
3. IVRT (isovolumic relaxation time) - derived by placing the cursor of Continuous wave (CW) Doppler in the LV outflow tract to simultaneously display the end of aortic ejection and the onset of mitral inflow.
4. Deceleration time (DT) - from the peak of E wave to baseline.
5. E/e'- PW tissue Doppler imaging (TDI) was performed in the apical views to acquire mitral annular velocities. The sample volume will be positioned at or 1 cm within the mitral leaflet's septal and lateral insertion sites.
6. Left atrial volume and left atrial volume index (LAVI) - The maximal left atrial (LA) volume measured from the apical four-chamber view using the modified Simpson method in end-systole before mitral valve opening. The LAVI obtained for all patients by dividing the LA volume by the body surface area.
Biochemical measurements:
Peripheral blood samples were obtained within 48 hours after acute MI, and the serum will be frozen at -70°C until tested for Galactin-3 level.
Follow up 2D Doppler echocardiography:
All previous echocardiographic measurements will be repeated at 40 days of the event.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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STEMI patients who underwent PPCI
2D Echocardiography with color Doppler assessment will be done within 24 h after PPCI
Biochemical measurements:
Peripheral blood samples were obtained within 48 hours after acute MI, and the serum will be frozen at -70°C until tested for Galactin-3 level.
Follow up 2D Doppler echocardiography will be repeated at 40 days of the event.
2D Echocardiography with color Doppler assessment & Galactin-3 level in blood
* Measurements will be
1. Pulsed wave (PW) Doppler
2. E (early diastolic)/A (late diastolic) - Using PW Doppler
3. IVRT (isovolumic relaxation time)
4. Deceleration time (DT) - from the peak of E wave to baseline.
5. E/e'- PW tissue Doppler imaging (TDI)
6. Left atrial volume and left atrial volume index (LAVI)
* Peripheral blood samples will be obtained within 48 hours after acute MI, and the serum will be frozen at -70°C until tested for Galactin-3 level.
Interventions
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2D Echocardiography with color Doppler assessment & Galactin-3 level in blood
* Measurements will be
1. Pulsed wave (PW) Doppler
2. E (early diastolic)/A (late diastolic) - Using PW Doppler
3. IVRT (isovolumic relaxation time)
4. Deceleration time (DT) - from the peak of E wave to baseline.
5. E/e'- PW tissue Doppler imaging (TDI)
6. Left atrial volume and left atrial volume index (LAVI)
* Peripheral blood samples will be obtained within 48 hours after acute MI, and the serum will be frozen at -70°C until tested for Galactin-3 level.
Eligibility Criteria
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Inclusion Criteria
1. Acute typical chest pain
2. Positive cardiac enzymes.
3. ECG shows ST-segment elevation MI
4. Documented occlusion of CA then treatment by PPCI
Exclusion Criteria
2\. Patients with the end-stage renal disease usually have markedly increased galactin-3 levels 3. Prior use of thrombolytic agents 4. Refusal of PPCI due to social or religious concerns 5. ST elevation on ECG without obvious coronary artery diseases such as acute myocarditis, early repolarization, or Takotsubo cardiomyopathy 6. Atrial fibrillation at the time of echocardiography examination.
18 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Mariam Bady Adly Hanna
Mariam Bady Adly Hanna
Principal Investigators
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Hatem Helmy, Professor
Role: PRINCIPAL_INVESTIGATOR
Assiut University
Locations
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Faculty of Medicine Assiut University
Asyut, Asyut Governorate, Egypt
Countries
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Central Contacts
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Facility Contacts
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Mariam Hanna
Role: primary
References
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Karaye KM, Sani MU. Factors associated with poor prognosis among patients admitted with heart failure in a Nigerian tertiary medical centre: a cross-sectional study. BMC Cardiovasc Disord. 2008 Jul 22;8:16. doi: 10.1186/1471-2261-8-16.
McManus DD, Chinali M, Saczynski JS, Gore JM, Yarzebski J, Spencer FA, Lessard D, Goldberg RJ. 30-year trends in heart failure in patients hospitalized with acute myocardial infarction. Am J Cardiol. 2011 Feb 1;107(3):353-9. doi: 10.1016/j.amjcard.2010.09.026.
Other Identifiers
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PPCI in STEMI patients
Identifier Type: -
Identifier Source: org_study_id