NFC Changes in SLE Patients and Its Correlation With Anti-U1RNPAntibodies and Disease Activity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

85 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-31

Study Completion Date

2023-06-30

Brief Summary

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1. Detection of different pattern of nail fold capillary changes in SLE patient.
2. Correlation of nail fold capillary changes in SLE patients and Anti-U1RNP antibodies.
3. Correlation of nail fold capillary changes with SLE disease activity.
4. Frequency of nail fold capillary changes in SLE patients

Detailed Description

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Systemic lupus erythematosus is a complex, multi-organ autoimmune disease . The presence of autoantibodies and circulating immune complexes can cause vasculitis and damage the endothelial cells, leading to multiple organ dysfunctions .The clinical manifestations of SLE include muco cutaneous, musculoskeletal system, cardiac, neurological, renal, hematologic, and vascular system involvement . Nail fold capillaroscopy (NFC) is a non-invasive easily repeatable technique and the best method for morphological analysis of nutritional capillaries in the nail fold area . Nail fold capillary changes are very common in patients with SLE. the major NFC pattern that has been reported in SLE patients was non-specific sub-types, followed by normal pattern and scleroderma pattern. In (SLE) patients are reported a large spectrum of antibodies, including the anti-ribonucleoproteins (RNP) antibodies These antibodies were linked to several clinical manifestations and prognostic in patients with SLE. Anti-U1-RNP antibodies are involved in both innate and adaptive immune responses during pathogenesis of connective tissue diseases 12. U1-RNP complex is an intra nuclear protein that converts pre-mRNA to mature RNA and constitutes three specific proteins A, C, and 70 kDa. High titer RNP antibodies are detected in MCTD patients and correlated with Clinical disease activity index and the frequent complication of pulmonary artery hypertension in those patients . It also has been found that NFC may detect subclinical microvascular changes in SLE in the presence of anti-U1-RNP antibodies and may facilitate early preventive therapy for major organ vasculopathy .

Conditions

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System Lupus Erythematosus

Keywords

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nailfold capillaroscopy anti-U1RNP antibodies Disease activity

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Interventions

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nailfold capillaroscopy

Nailfold capillaroscopy (NFC) is a non-invasive easily repeatable technique and the best method for morphological analysis of nutritional capillaries in the nailfold area

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Adult SLE Patients who fulfilled the 2012 systemic lupus international collaborating clinics (SLICC) criteria

Exclusion Criteria

1. SLE patient aged less than 18 yeares old.
2. Individuals with other autoimmune diseases (rheumatoid arthritis dermatomyositis, scleroderma, mixed connective tissue disease).
3. Congestive cardic failure and presence of clupping.
4. Coexisting diabetes mellitus.
5. history of smoking.
6. Patients unable to co-operate for nailfold capillaroscopic examination

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Amera Imam Abdel - Ghany Ahmed

Resident doctor at Physical medicine ,Rheumatology and Rehabilitation department

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Amera I. Abdel-Ghany, Dr

Role: CONTACT

Phone: 01003139319

Email: [email protected]

Yasmine S. Makarem, Dr

Role: CONTACT

Phone: 01002929015

Email: [email protected]

References

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Zhao T, Lin FA, Chen HP. Pattern of Nailfold Capillaroscopy in Patients With Systemic Lupus Erythematosus. Arch Rheumatol. 2020 Apr 20;35(4):568-574. doi: 10.46497/ArchRheumatol.2020.7763. eCollection 2020 Dec.

Reference Type BACKGROUND

PMID: 33758813 (View on PubMed)

Chebbi PP, Goel R, Ramya J, Gowri M, Herrick A, Danda D. Nailfold capillaroscopy changes associated with anti-RNP antibodies in systemic lupus erythematosus. Rheumatol Int. 2022 Aug;42(8):1355-1361. doi: 10.1007/s00296-021-04894-4. Epub 2021 Jun 2.