The Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease
NCT ID: NCT05102045
Last Updated: 2021-11-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
27 participants
INTERVENTIONAL
2016-09-01
2017-06-01
Brief Summary
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Methods: Twenty-seven AD patients aged ≥60 years were included in the study and divided into 3 groups (rTMS, Aerobic Exercise (AE) and control). All groups received pharmacological treatment. rTMS group (n=10) received 20 Hz rTMS treatment on bilateral dorsolateral prefrontal cortex, 5 days a week over 2 weeks, and AE group (n=10) received the moderate-intensity aerobic exercise for 50 min sessions, 5 days a week over 2 weeks. Control group (n=10) was only treated pharmacologically. Neuropsychiatric and behavioral status, cognition, balance, functional mobility, and quality of life, and functional brain changes were evaluated before and after the treatment.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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TMS group
In the TMS group (n=10) rTMS was applied to the bilateral dorsolateral prefrontal cortex (DLPFC) at 20 Hz, for 5 consecutive days per week for over 2 weeks (totally 10 sessions) in addition to the pharmacological treatment.
Repetitive Transcranial Magnetic Stimulation
TMS is a non-invasive application that induces changes in neuronal polarization and activity by causing the induction of weak electric currents in a rapidly changing magnetic field. Repetitive TMS (rTMS) refers to the application of regular TMS pulses at fixed intervals.
Acetylcholinesterase Inhibitors
Donepezil, Rivastigmine, Galantamine were given in combination for Alzheimer's disease.
Memantine
Memantine were given for Alzheimer's disease. .
AE group
AE group (n=9) received a moderate- intensity aerobic exercise program lasting 50 minutes per session, 5 consecutive days per week for over 2 weeks (totally 10 sessions) in addition to the pharmacological treatment.
Aerobic Exercise
Brisk exercise that promotes the circulation of oxygen through the blood and is associated with an increased rate of breathing.
Acetylcholinesterase Inhibitors
Donepezil, Rivastigmine, Galantamine were given in combination for Alzheimer's disease.
Memantine
Memantine were given for Alzheimer's disease. .
Control group
No additional intervention was given to the patients in the control group (n=8) and participants were only treated pharmacologically.
Acetylcholinesterase Inhibitors
Donepezil, Rivastigmine, Galantamine were given in combination for Alzheimer's disease.
Memantine
Memantine were given for Alzheimer's disease. .
Interventions
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Repetitive Transcranial Magnetic Stimulation
TMS is a non-invasive application that induces changes in neuronal polarization and activity by causing the induction of weak electric currents in a rapidly changing magnetic field. Repetitive TMS (rTMS) refers to the application of regular TMS pulses at fixed intervals.
Aerobic Exercise
Brisk exercise that promotes the circulation of oxygen through the blood and is associated with an increased rate of breathing.
Acetylcholinesterase Inhibitors
Donepezil, Rivastigmine, Galantamine were given in combination for Alzheimer's disease.
Memantine
Memantine were given for Alzheimer's disease. .
Eligibility Criteria
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Inclusion Criteria
* being 60 years and older
* having Clinical Dementia Rating Scale (CDR) scores 1 or 2
* living independently
Exclusion Criteria
* having physical disabilities,
* having a history of alcohol / substance abuse,
* having head trauma
* having epileptic seizures
60 Years
ALL
No
Sponsors
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Istanbul Medipol University Hospital
OTHER
Responsible Party
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Miray Budak
Principal Investigator
Locations
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Istanbul Medipol University
Istanbul, Beykoz, Turkey (Türkiye)
Countries
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References
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Budak M, Bayraktaroglu Z, Hanoglu L. The effects of repetitive transcranial magnetic stimulation and aerobic exercise on cognition, balance and functional brain networks in patients with Alzheimer's disease. Cogn Neurodyn. 2023 Feb;17(1):39-61. doi: 10.1007/s11571-022-09818-x. Epub 2022 May 30.
Other Identifiers
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Alzheimer.rTMS.fMRI
Identifier Type: -
Identifier Source: org_study_id