Platelet Rich Fibrin and Concentrated Growth Factors on Osseointegration of Immediate Implants

NCT ID: NCT05101954

Last Updated: 2021-11-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-01

Study Completion Date

2021-08-17

Brief Summary

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This study will involve 14 patients with mandibular premolars indicated for extraction and immediate replacement. The patients will be randomly allocated into two groups and each patient will receive one implant. In Group A, a CGF membrane will be laid in the implant cavity. While in Group B, a PRF membrane will be laid in the implant cavity. Bone graft material will be applied to fill the empty parts of the socket.

Resonance frequency measurement will be done using the OSTELL device intraoperatively, at the 1st week and after 3 months. Cone-beam computed tomography will be done preoperatively, immediately following surgery, and after 3 months

Detailed Description

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Conditions

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Tooth Extraction Dental Implants

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Group A

Group Type EXPERIMENTAL

Concentrated Growth Factors (CGF)

Intervention Type PROCEDURE

Concentrated Growth Factors membrane will be laid in the implant cavity. Bone graft material will be applied to fill the empty parts of the socket.

Group B

Group Type ACTIVE_COMPARATOR

Platelet-Rich Fibrin (PRF)

Intervention Type PROCEDURE

Platelet-Rich Fibrin (PRF) membrane will be laid in the implant cavity. Bone graft material will be applied to fill the empty parts of the socket.

Interventions

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Concentrated Growth Factors (CGF)

Concentrated Growth Factors membrane will be laid in the implant cavity. Bone graft material will be applied to fill the empty parts of the socket.

Intervention Type PROCEDURE

Platelet-Rich Fibrin (PRF)

Platelet-Rich Fibrin (PRF) membrane will be laid in the implant cavity. Bone graft material will be applied to fill the empty parts of the socket.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Cooperative patients with good oral hygiene.
* Patients having a history of mandibular premolars indicated for extraction and immediate replacement.

Exclusion Criteria

* Heavy smokers.
* Parafunctional occlusal habits.
* Uncontrolled diabetes.
* History of chemotherapy or radiotherapy.
* Hematological disorders that prevent either implantation or centrifugation.
* Pregnancy.
* The nee¬d for additional augmentation or previous augmentation of the same region.
* Chronic periapical pathology
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hams Hamed Abdelrahman

OTHER

Sponsor Role lead

Responsible Party

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Hams Hamed Abdelrahman

Assistant lecturer of DPH and Clinical statistician

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Alexandria Faculty of Dentistry

Alexandria, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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PRF_GF_2019/2020

Identifier Type: -

Identifier Source: org_study_id