The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION)

NCT ID: NCT05100719

Last Updated: 2021-10-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-30

Study Completion Date

2026-12-31

Brief Summary

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Irritable bowel syndrome (IBS) is a functional gastrointestinal disease. There is no well-defined pharmacological treatment. This clinical trial is a prospective, double-blind, two-armed randomized controlled, single-center trial. It is created to examine the role of IBS in patients with lactose intolerance. IBS patients undergo lactose H2 breath test (LHBT) and lactose tolerance test (LTT). Those with positive LTT and LHBT will be randomized into two groups: alverine-citrate + simethicone and lactase group (1) or alverin-citrate + simethicone with the placebo group (2). The goal of this study is to compare the lactase enzyme with placebo in IBS patients with lactose intolerance.

Detailed Description

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Irritable bowel syndrome (IBS) is one of the most frequently diagnosed gastroenterological disorders and can lead to significant deterioration of quality of life and an increase in health care and societal costs. Patients with lactose intolerance are unable to fully digest lactose caused by lactose malabsorption. The undigested lactose moves into the large intestine, fermented by bacteria, and causes bloating, gas, and diarrhea symptoms. The two, most frequently used diagnostic methods are the lactose H2 breath test (LHBT) and the lactose tolerance test (LTT). The restriction of lactose input or the replacement of the lactase enzyme can lead to the relief of the symptoms. Lactose intolerance is a common disorder among patients with IBS, it is more frequent than in the general population.

There are no studies that assess the link between lactose intolerance and IBS. Our primary objective is the examination of the relationship between lactose intolerance and IBS with or without the replacement of lactase enzyme. Our secondary objectives are to compare the lactase/beta-galactosidase enzyme replacement with placebo with the evaluation of a TSS (Total symptom score), VAS (Visual Analog Scale), QoL (Quality of life) questionnaires. The other secondary outcomes are to compare the severity of baseline symptoms during and after lactose administration.

Patients diagnosed with IBS according to the Rome IV criteria will test with LTT and LHBT.

Who has positive LTT and LHBT will randomize into two groups: (1) alverine-citrate + simethicone and lactase; (2) alverin-citrate + simethicone with placebo.

Conditions

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Irritable Bowel Syndrome Lactose Intolerance Lactose Malabsorption

Keywords

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irritable bowel syndrome lactose intolerance lactose malabsorption lactase simethicone alverine-citrate placebo

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

LION is a two-armed, randomized, double-blind, placebo-controlled, two-phase clinical trial. In the first phase, we will enroll 100 patients, the allocation ratio will be 1:1 (50 patinets in each arm). Then, an interim analysis will be performed to determine the appropriate sample size. During the interim analysis, if there is already significant difference (p\<0.0294) between the arms, the recruitment will be considered completed; otherwise, recruitment will continue until the desired sample size is reached. If there is no hope for ascertaining significance, the study will be stopped.
Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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alverine-citrate + simethicone and lactase

Patients diagnosed with irritable bowel syndrome based on the ROME IV criteria will go through a lactase intolerance test (LTT) and (lactose H2 breath test) LHBT. Those who have positive LTT and LHBT will receive alverine-citrate + simethicone and lactase.

Group Type ACTIVE_COMPARATOR

alverine-citrate + simethicone and lactase

Intervention Type DRUG

Patients who randomized in the first arm are treated with alverine-citrate + simethicone and lactase.

alverin-citrate + simethicone with placebo

Patients diagnosed with irritable bowel syndrome based on the ROME IV criteria will go through a lactase intolerance test (LTT) and (lactose H2 breath test) LHBT. Those who have positive LTT and LHBT will receive alverine-citrate + simethicone with placebo.

Group Type PLACEBO_COMPARATOR

alverin-citrate + simethicone with placebo

Intervention Type DRUG

Patients in the second arm receive alverin-citrate + simethicone with placebo without lactase.

Interventions

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alverine-citrate + simethicone and lactase

Patients who randomized in the first arm are treated with alverine-citrate + simethicone and lactase.

Intervention Type DRUG

alverin-citrate + simethicone with placebo

Patients in the second arm receive alverin-citrate + simethicone with placebo without lactase.

Intervention Type DRUG

Other Intervention Names

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lactase placebo

Eligibility Criteria

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Inclusion Criteria

* age 18-80 years
* patients diagnosed with irritable bowel syndrome based on the ROME IV. criteria
* positive LHBT (lactose H2 breath test) and LTT (lactose tolerance test) results
* negative abdominal ultrasound/CAT scan/MRI results within one year
* signed the informed consent

Exclusion Criteria

* organic gastroenterological disorders which can explain symptoms (e.g. positive serological screening: anti-gliadin IgG / IgA, anti-tissue transglutaminase IgG / IgA, high level of fecal calprotectin tested by endoscopy or positive colonoscopy for IBD, currently active diverticulitis
* Alarm symptoms: fever (\> 38 Co), anaemia (Hgb \< 120 g/l), unintended weight loss (\> 4.5 kg / 3 months), gastrointestinal bleeding (hematemesis, hematochesia, melena)
* cardiac failure (NYHA III-IV)
* liver cirrhosis (Child-Pugh C)
* active malignancy
* major abdominal surgery in the history
* pregnant or breastfeeding women
* any circumstances which can lead to false results of LHBT and LTT: cigarette smoking or physical exercise within 2 hours before the test, ingestion of dietary fibers on the evening before the test, recent use of antibiotics, lung disease, baseline H2 concentration in the exhaled air is higher than 20 ppm, not properly treated diabetes mellitus, following lactose restricted or another special diet within 1 week prior to study enrolment (ingestion of less than 12 g lactose - less than 250 ml milk - per day)
* small intestinal bacterial overgrowth (SIBO): if there is a rapid increase of H2 level in the exhaled air (≥20 ppm above baseline within 90 minutes), SIBO is suspected and antibiotic therapy will be started (peroral rifaximin for 5 days) after negative Helicobacter pylori serology. After this procedure, lactulose H2 breath test will be performed to exclude SIBO (≥20 ppm H2 rise only after 90 min). In case of negative lactulose H2 breath test, another LHBT will be carried out
* slow oro-cecal transit: clinical signs and typical findings on the tests (the LHBT is normal, but the increase of blood glucose level is less than 1.1 mmol/l and/or no H2 rise during lactulose H2 breath test)
* milk allergy (positive IgE test)
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Pecs

OTHER

Sponsor Role lead

Responsible Party

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József Czimmer

Divison of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Institute for Translational Medicine, University of Pécs

Pécs, , Hungary

Site Status

Countries

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Hungary

References

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Related Links

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http://tm-centre.org/

LION is designed and coordinated by the Centre for Translational Medicine (Medical School, University of Pécs). This link redirects to the official website of the institute.

Other Identifiers

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IV/4455-3/2021/EKU

Identifier Type: -

Identifier Source: org_study_id