Ocular Manifestation and Related Risk Factors of Covid-19 Associated Mucormycosis: a Multicenter Study in Iran

NCT ID: NCT05097664

Last Updated: 2021-10-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-08-23

Study Completion Date

2022-01-20

Brief Summary

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Coronavirus disease 2019 (COVID-19) infection caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may manifest as a variety of disease patterns, ranging from mild to life-threatening pneumonia.

Mucormycosis has been suspected to cause significant morbidity in infected people since the outbreak of the COVID-19 pandemic. Individuals who require hospitalization and intensive care are more vulnerable, as they have reached an advanced stage of their disease. Investigators will discuss the major risk factors, ocular presentation, and outcome of mucormycosis in individuals infected with SARS-CoV-2 in this study. From August 2021 to January 2022, a cross-sectional descriptive multicenter investigation would be conducted on patients with biopsy-confirmed mucormycosis and RTPCR confirmed COVID19. Demographic data, the time interval between COVID19 and mucormycosis, underlying systemic disorders, clinical characteristics, disease course, and outcomes would be analyzed.

Detailed Description

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Investigators will achieved the following data from the participants:

1. Demographic
2. Past medical/habitual history
3. COVID-19 status and related risk factors
4. Mucormycosis status and related risk factors
5. Ocular examination and imaging
6. Follow-up

Conditions

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COVID-19 Mucormycosis

Keywords

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Coronavirus Disease-Associated Mucormycosis COVID-19 Rhino-orbital-cerebral mucormycosis Mucormycosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Diagnosed case of Mucormycosis in COVID-19 pandemic

Exclusion Criteria

* People with acute or severely ill conditions that prevent them from ophthalmic examination.
* Patient, or legal representative opposing the pursuit of the research
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shiraz University of Medical Sciences

OTHER

Sponsor Role collaborator

Ahvaz Jundishapur University of Medical Sciences

OTHER

Sponsor Role collaborator

Iran University of Medical Sciences

OTHER

Sponsor Role collaborator

Mashhad University of Medical Sciences

OTHER

Sponsor Role collaborator

Tabriz University of Medical Sciences

OTHER

Sponsor Role collaborator

Guilan University of Medical Sciences

OTHER

Sponsor Role collaborator

Kermanshah University of Medical Sciences

OTHER

Sponsor Role collaborator

Shahid Beheshti University of Medical Sciences

OTHER

Sponsor Role collaborator

Semnan University of Medical Sciences

OTHER

Sponsor Role collaborator

Isfahan University of Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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Mohsen Pourazizi

Dr. Mohsen Pourazizi

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mohsen Pourazizi, M.D.

Role: PRINCIPAL_INVESTIGATOR

Isfahan Eye Research Center

Locations

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Isfahan University of Medical Sciences

Isfahan, , Iran

Site Status RECRUITING

Countries

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Iran

Central Contacts

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Mohsen Pourazizi, M.D.

Role: CONTACT

Phone: 00983134452036

Email: [email protected]

Facility Contacts

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Mohsen Pourazizi

Role: primary

References

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Eshraghi B, Khademi B, Bahmani Kashkouli M, Khataminia G, Kiarudi MY, Nabie R, Abounoori M, Chaibakhsh S, Ghahvehchian H, Rastegarnasab F, Parandin M, Zia Z, Karamirad S, Jafarpour S, Fakoor M, Varshochi M, Mirmohammadkhani M, Ramezani-Majd A, Janipour M, Mahdian Rad A, Shekarchian F, Manouchehri V, Sajjadi SMJ, Etezad Razavi M, Khosropour H, Forouhari A, Ebrahimi F, Pourazizi M. One-Year Patient Survival After COVID-19-Associated Rhino-Orbital-Cerebral Mucormycosis: A Multicenter Study. Mycopathologia. 2025 Jul 6;190(4):63. doi: 10.1007/s11046-025-00966-2.

Reference Type DERIVED
PMID: 40619554 (View on PubMed)

Other Identifiers

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IR.MUI.MED.REC.1400.572

Identifier Type: -

Identifier Source: org_study_id