High Flow Nasal Therapy in Covid 19 Patient

NCT ID: NCT05094648

Last Updated: 2021-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-11-01

Study Completion Date

2022-09-30

Brief Summary

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This study aims to To identify factors that predict success of high flow nasal therapy in covid19 patients .

Detailed Description

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Coronavirus disease 2019 (COVID-19) is a potentially fatal infection caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)\[1\]. The highly contagious nature and exponential spread of SARS-CoV-2, coupled with its potential for a rapid progressto acute respiratory distress syndrome (ARDS), has overwhelmed health care systems globally, contributing to the high mortality rates in early reports \[1,2\].

The initial approach for respiratory support for severe COVID-19 pneumonia centredaround invasive mechanical ventilation and the standard lung protective strategy recommended for ARDS\[3\]. This may have been detrimental to a proportion of patients due to ventilator induced lung injury (VILI) and associated systemic inflammation\[4\]. Furthermore, other strategies to improve oxygenation may be more appropriate in patients with hypoxemic respiratory failure who do not require ventilatorysupport\[4\].

High-flow nasal oxygen (HFNO) is delivered by an air/oxygen blender, an active humidifier, a single heated circuit, and a nasal interface.

It delivers adequately heated and humidified medical gas at flow-rates of up to 60L/min, and is considered to have a number of physiological benefits, including the reduction of anatomical dead space and work of breathing, the provision of a constant fraction of inspired oxygen with adequate humidification and a degree of positive end-expiratory pressure (PEEP) \[5,6\].

Conditions

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High Flow Nasal Therapy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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group A

Covidpatient Who pass on high flow nasal therapy

high flow nasal therapy

Intervention Type OTHER

effect of high flow nasal therapy in covid 19 patients who pass and who need non invasive

group B

Covidpatient who failed on high flow nasal therapy and need NIV

high flow nasal therapy

Intervention Type OTHER

effect of high flow nasal therapy in covid 19 patients who pass and who need non invasive

Interventions

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high flow nasal therapy

effect of high flow nasal therapy in covid 19 patients who pass and who need non invasive

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All Patients above 18 y old that will be diagnosed as COVID 19 based on PCR testing, who fulfil criteria that indicate need for high flow nasal therapy.

Exclusion Criteria

* o Children less than 18 y old

* Oropharyngeal and Nasopharyngeal swap negative patients
* Patients who will refuse inclusion in the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Maha Mahmoud Ahmed

OTHER

Sponsor Role lead

Responsible Party

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Maha Mahmoud Ahmed

Assistant Lecturer

Responsibility Role SPONSOR_INVESTIGATOR

Central Contacts

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Maha Mahmoud

Role: CONTACT

Phone: 01063453193

Email: [email protected]

samiaa sadik

Role: CONTACT

Phone: 01006769597

Email: [email protected]

References

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Nishimura M. High-Flow Nasal Cannula Oxygen Therapy in Adults: Physiological Benefits, Indication, Clinical Benefits, and Adverse Effects. Respir Care. 2016 Apr;61(4):529-41. doi: 10.4187/respcare.04577.

Reference Type BACKGROUND
PMID: 27016353 (View on PubMed)

Other Identifiers

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nasal therapy in covid patient

Identifier Type: -

Identifier Source: org_study_id