Nerve Composition of Human Lumbar Dorsal Primary Rami and Its Medial Branch

NCT ID: NCT05091112

Last Updated: 2024-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-08

Study Completion Date

2024-12-31

Brief Summary

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The purpose of the study is to understand the composition of the nerves supplying the facet joints in low back.

Detailed Description

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After written informed consent, the nerves supplying the facet joints - lumbar dorsal rami and its medial branches, will be harvested when they are exposed during spinal surgery. These nerves will be fixed, washed and further dissected to enable smaller sections. The cut section will be stained and subjected to analysis of overall cross-sectional area and presence of connective tissue sheaths under light microscope.

Conditions

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Lumbar Facet Arthrosis Nerve Degeneration

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Active group

Patients who are scheduled to undergo lumbar spinal surgery and fulfill the inclusion and exclusion criteria

Spinal surgery

Intervention Type PROCEDURE

In participants who undergo elective lumbar spinal surgery and consented for research, the medial branch and dorsal rami will be harvested for histological analysis.

Histology

Intervention Type OTHER

The harvested nerves will be fixed, cut into smaller sections. Analysis of macroscopic and light microscopic sections will be carried out

Interventions

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Spinal surgery

In participants who undergo elective lumbar spinal surgery and consented for research, the medial branch and dorsal rami will be harvested for histological analysis.

Intervention Type PROCEDURE

Histology

The harvested nerves will be fixed, cut into smaller sections. Analysis of macroscopic and light microscopic sections will be carried out

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Be aged 18 or over
* be able to give informed consent
* scheduled to undergo lumbar spinal surgery

Exclusion Criteria

* Children under 18 years old
* Vulnerable adults
* Adults with incapacity
* Inability to provide informed consent
* History of previous spinal surgery
* history of previous RF ablation for low back pain
* has COVID-19 or displaying symptoms of COVID-19
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Aberdeen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Saravanakumar Kanakarajan, MD FRCA

Role: PRINCIPAL_INVESTIGATOR

NHS Grampian

Locations

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Woodend Hospital

Aberdeen, Scotland, United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Saravanakumar Kanakarajan, MD FRCA

Role: CONTACT

Phone: 00 44 1224 553237

Email: [email protected]

Facility Contacts

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Santosh Baliga, MbChB, FRCS

Role: primary

Other Identifiers

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1-076-21

Identifier Type: -

Identifier Source: org_study_id