Prospective Comparison of 18F-FDG and 18F-FET PET for Response Evaluation in Patients With Primary Central Nervous System Lymphoma

NCT ID: NCT05083936

Last Updated: 2021-10-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-27

Study Completion Date

2023-03-31

Brief Summary

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The overall goal of this imaging trial is to prospectively compare the usefulness of 18F-FDG PET and 18F-FET PET in evaluating treatment response and predicting prognosis in patients with central nervous system lymphoma.

Detailed Description

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Conditions

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Patients With Suspected or Diagnosed Central Nervous System Lymphoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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[18F]FET PET

Group Type EXPERIMENTAL

[18F]FET

Intervention Type DRUG

Imaging evaluation using LAT1/4F2hc substrate overexpressed in brain tumor

Interventions

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[18F]FET

Imaging evaluation using LAT1/4F2hc substrate overexpressed in brain tumor

Intervention Type DRUG

Other Intervention Names

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Fluoroethyl-L-tyrosine

Eligibility Criteria

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Inclusion Criteria

In order to be eligible for participation in this trial, the subject must:

* Be ≥ 19 years of age.
* Patients diagnosed with central nervous system lymphoma by surgery/biopsy or suspected of central nervous system lymphoma by anatomical imaging examination such as MRI.
* Patients who have results or are planning to examine 18F-FDG PET in the above patients.

Exclusion Criteria

The subject must be excluded from participating in the trial if the subject fulfil any single criteria described below:

* Pediatric and adolescent patients under 19 years of age.
* The patient is pregnant, is attempting to become pregnant, or is nursing (breast-feeding) to children.
* Patients with diagnosed or suspected lymphoma lesions in organs other than the cetral nervous system.
* Based on the investigator's judgement, if the patient makes it impossible to collect complete data for a clinical trial due to personal or other reasons.
* Patients who cannot stably have PET/CT due to claustrophobia, dyskinesia, anxiety disorder, seizure, etc.
* Based on the investigator's judgement, if the patient has a serious and/or uncontrolled and/or unstable medical disease (e.g., congestive heart failure, acute myocardial infarction, severe lung disease, chronic renal disease or chronic liver disease, etc.)
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Asan Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Minyoung Oh

Assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Asan Medical Center

Seoul, Songpa-Gu, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Minyoung Oh, M.D.,Ph.D.

Role: CONTACT

+82-2-3010-1447

Facility Contacts

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Minyoung Oh, M.D.,Ph.D.

Role: primary

+82-2-3010-1447

Other Identifiers

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FET-PCNSL

Identifier Type: -

Identifier Source: org_study_id