Efficacy of Letrozole Versus Clomiphene Citrate on Ovulation Induction in Patients With Polycystic Ovarian Syndrome

NCT ID: NCT05075863

Last Updated: 2021-10-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

78 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-01

Study Completion Date

2021-06-30

Brief Summary

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We aimed this study to determine and compare frequency of induction of ovulation in women with polycystic ovarian syndrome treated with Letrozole versus clomiphene citrate as published literature shows variations.

Detailed Description

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Discrepancy between ovulation induction rate and pregnancy rate is related to anti-estrogenic effects on cervical mucus and endometrium and long acting gonadotrophins are more effective than clomiphene citrate. This study was aimed at comparing frequency of induction of ovulation in women with polycystic ovarian syndrome treated with Letrozole versus clomiphene citrate.

Conditions

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Polycystic Ovary Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized controlled trial
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Clomiphene Citrate

A total of 39 women were given clomiphene citrate, 100mg from 3 to 7 days of menstrual cycle. All patients underwent transvaginal scan (TVS) so that efficacy could be evaluated (ovulation occurs on 14 day of menstrual cycle after a treatment of 5 days of both groups. Induction of ovulation was assessed by TVS. If follicle of \>2cm is found on 12 days TVS and smaller/collapsed on 16 days TVS, ovulation induction was labeled.

Group Type EXPERIMENTAL

Letrozole

Intervention Type DRUG

Letrozole as 5mg from day 3 to 7 of menstrual cycle

Letrozole

A total of 39 women were given letrozole, 5mg from day 3 to 7 of menstrual cycle. All patients underwent transvaginal scan (TVS) so that efficacy could be evaluated (ovulation occurs on 14 day of menstrual cycle after a treatment of 5 days of both groups. Induction of ovulation was assessed by TVS. If follicle of \>2cm is found on 12 days TVS and smaller/collapsed on 16 days TVS, ovulation induction was labeled.

Group Type EXPERIMENTAL

Letrozole

Intervention Type DRUG

Letrozole as 5mg from day 3 to 7 of menstrual cycle

Interventions

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Letrozole

Letrozole as 5mg from day 3 to 7 of menstrual cycle

Intervention Type DRUG

Other Intervention Names

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Femara

Eligibility Criteria

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Inclusion Criteria

* Diagnosed cases of polycystic ovarian syndrome.

Exclusion Criteria

* All women having endocrine disorders like thyroid disorders.
* Women having hyperprolactinemia.
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Nishtar Medical University

OTHER

Sponsor Role lead

Responsible Party

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Rashida Parveen

Consultant Gynecologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Rashida Parveen, FCPS

Role: PRINCIPAL_INVESTIGATOR

Nishtar Medical University

Locations

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Nishtar Medical University Hospital

Multan, Punjab Province, Pakistan

Site Status

Countries

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Pakistan

Other Identifiers

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NishtarMU1

Identifier Type: -

Identifier Source: org_study_id