Variance of HRD From Paired Ovarian Cancer

NCT ID: NCT05069818

Last Updated: 2021-10-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-31

Study Completion Date

2022-12-31

Brief Summary

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Homologous recombination deficiency (HRD) is an important biomarker of poly (ADP-ribose) polymerase inhibitor (PARPi) in patients with high-grade serous ovarian cancer (HGSOC). The stability of HRD in the recurrent HGSOC and its primary pair remains unknown.

Detailed Description

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This study intends to perform HRD testing of ovarian cancer in the recurrent HGSOC and its primary pair, furtherly correlate HRD status and clinical characteristics in the recurited population.

Conditions

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Ovarian Cancer HRD Platinum-sensitive Ovarian Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Subjects join the study voluntarily and sign informed consent;
2. Female subjects are older than 18 years;
3. ECOG(Eastern Cooperative Oncology Group) physical status score is 0-2;
4. Life expectancy≥3 months;
5. Histologically confirmed FIGO(International Federation of Gynecology and Obstetrics ) III/IV ovarian cancer, fallopian tube cancer, or primary peritoneal cancer; Participants must have high-grade serous histology

Exclusion Criteria

1. Personnel involved in the formulation or implementation of the research plan;
2. The subjects had other malignant diseases in past 2 years, except skin squamous cell carcinoma, basal-like carcinoma, breast intraductal carcinoma in situ, or cervical carcinoma in situ;
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Xiaoxiang Chen

OTHER

Sponsor Role lead

Responsible Party

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Xiaoxiang Chen

Academic secretary of gynecological oncology Committee of Jiangsu anti cancer association

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Xiaoxiang Chen Chen, MD,PhD

Role: STUDY_CHAIR

Jiangsu Cancer Institute & Hospital

Locations

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Xiaoxiang Chen

Nanjing, Jiangsu, China

Site Status

Countries

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China

Central Contacts

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Jing Ni, MD

Role: CONTACT

+86 13327833586

Xiaoxiang Chen, MD,PhD

Role: CONTACT

Facility Contacts

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Jing Ni, MD

Role: primary

+8613813833586

Xiaoxiang Chen

Role: backup

Other Identifiers

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JiangsuCIH011

Identifier Type: -

Identifier Source: org_study_id

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