A Study to Test the Efficacy, Safety and Tolerability of Romosozumab Treatment in Postmenopausal Chinese Women With Osteoporosis

NCT ID: NCT05067335

Last Updated: 2024-12-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 327 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-10-21
• Study Completion Date: 2023-11-09

Brief Summary

The purpose of the study is to evaluate the effect of treatment with romosozumab for 6 months compared with placebo on the percent changes in bone mineral density (BMD) at the lumbar spine, at the total hip and femoral neck in postmenopausal Chinese women with osteoporosis.

Conditions

Osteoporosis

Keywords

Osteoporosis; Phase 3; Chinese Patients; Romosozumab

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

Romosozumab

Subjects randomized to this arm will receive romosozumab during all treatment Periods.

Group Type: EXPERIMENTAL

Romosozumab

Intervention Type: DRUG

Subjects will receive romosozumab in a specified sequence during the treatment Period.

Placebo

Subjects randomized to this arm will receive placebo during the Double-Blind-Placebo controlled Period and romosozumab during the Open-Label treatment Period

Group Type: PLACEBO_COMPARATOR

Romosozumab

Intervention Type: DRUG

Subjects will receive romosozumab in a specified sequence during the treatment Period.

Placebo

Intervention Type: DRUG

Subjects will receive Placebo in a specified sequence during the treatment Period.

Interventions

Romosozumab

Subjects will receive romosozumab in a specified sequence during the treatment Period.

Intervention Type: DRUG

Placebo

Subjects will receive Placebo in a specified sequence during the treatment Period.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Subject is considered reliable and capable of adhering to the protocol, visit schedule, and medication intake according to the judgment of the investigator
• Subject is an ambulatory postmenopausal Chinese women, 55 to 90 years of age (inclusive) at the time of Screening. Postmenopause is defined as no spontaneous vaginal bleeding or spotting for 12 or more consecutive months prior to Screening
• Subject has a bone mineral density (BMD) T-score ≤-2.50 at the lumbar spine, total hip, or femoral neck, as assessed by the central imaging vendor at the time of Screening based on DXA scans, and using data for Caucasian women from the National Health and Nutritional Examination Survey (NHANES, 1998)
• Subject must have at least 1 of following independent risk factors for fracture:

• History of fragility fracture (except hip fracture, a severe vertebral fracture or more than 2 moderate vertebral fractures)
• Parental history of hip fracture
• Low body weight (body mass index ≤19kg/m2)
• Elderly (age ≥ 65 years)
• Current smoker
• Subject has at least 2 vertebrae in the L1 to L4 region and at least 1 hip that are evaluable by dual-energy x-ray absorptiometry (DXA), as assessed by the central imaging vendor

Exclusion Criteria

• Subject has a BMD T-score of ≤-3.50 at the total hip or femoral neck, as assessed by the central imaging vendor at the time of Screening based on DXA scans, and using data for Caucasian women from NHANES 1998
• Subject has a known history of hip fracture
• Subject has any severe (SQ3) or more than 2 moderate (SQ2) vertebral fractures, as assessed by the central imaging vendor based on the lateral spine x-ray at Screening
• Subject has a history of myocardial infarction (MI)
• Subject has a history of stroke
• Subject has a vitamin D insufficiency, defined as 25 (OH) vitamin D levels <20 ng/mL, as assessed by the central laboratory at Screening. Vitamin D repletion will be permitted and the subject may be retested once within the Screening Period
• Subject has used oral bisphosphonates:

• Any doses received within 3 months prior to randomization
• More than 1 month of cumulative use between 3 and 12 months prior to randomization
• More than 3 years of cumulative use, unless the last dose was received ≥5 years prior to randomization
• Subject has used intravenous (iv) bisphosphonates:

• zoledronic acid

• Any doses received within 3 years prior to randomization
• More than 1 dose received within 5 years prior to randomization
• iv ibandronate, iv pamidronate, or iv alendronate (ALN)

• Any doses received within 12 months prior to randomization
• More than 3 years of cumulative use, unless the last dose was received ≥5 years prior to randomization
• Subject has used denosumab or any cathepsin K inhibitor:

● Any doses received within 18 months prior to randomization

• Subject has used tibolone, cinacalcet, or calcitonin:

• Any doses received within 3 months prior to randomization
• Subject has used teriparatide (TPTD) or any parathyroid hormone (PTH) derivative:

• Any doses received within 3 months prior to randomization
• More than 1 month of cumulative use between 3 and 12 months prior to randomization
• Subject has used systemic oral or transdermal estrogen or selective estrogen receptor modulators (SERMs):

● More than 1 month of cumulative use within 6 months prior to randomization

• Subject has used strontium ranelate or fluoride:

● More than 1 month of cumulative use within 5 years prior to randomization

• Subject has used hormonal ablation therapy:

● More than 1 month of cumulative use within 6 months prior to randomization

• Subject has used systemic glucocorticosteroids:

● ≥5mg prednisone equivalent per day for more than 14 days within 3 months prior to randomization

• Subject has a history of osteonecrosis of the jaw (ONJ) or atypical femoral fracture (AFF)
• Subject has evidence of any of the following:

1. Current, uncontrolled hyper- or hypothyroidism. Uncontrolled hyperthyroidism is defined as thyroid-stimulating hormone (TSH) and thyroxine (T4) outside of the normal range. Uncontrolled hypothyroidism is defined as TSH >10

2. Current, uncontrolled hyperparathyroidism or history of hypoparathyroidism. Uncontrolled hyperparathyroidism is defined as PTH outside the normal range in subjects with concurrent hypercalcemia or PTH values >20 % above upper limit of normal (ULN) in normocalcemic subjects

3. Current hypercalcemia or hypocalcemia, defined as albumin-adjusted serum calcium outside the normal range, as assessed by the central laboratory at the time of Screening. Albumin-adjusted serum calcium levels may be retested once in case of an elevated albumin-adjusted serum calcium level within 1.1xULN of the laboratory's reference ranges

4. Subject has ≥3xULN of any of the following: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), or >ULN total bilirubin (≥1.5xULN total bilirubin if known Gilbert's syndrome). If subject has elevations only in total bilirubin that are >ULN and <1.5xULN, fractionate bilirubin to identify possible undiagnosed Gilbert's syndrome (ie, direct bilirubin <35 %)

• Minimum Eligible Age: 55 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

UCB Biopharma SRL

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

UCB Cares

Role: STUDY_DIRECTOR

001 844 599 2273 (UCB)

Locations

Op0002 20040

Beijing, , China

Op0002 20115

Beijing, , China

Op0002 20125

Beijing, , China

Op0002 20127

Beijing, , China

Op0002 20128

Beijing, , China

Op0002 20130

Beijing, , China

Op0002 20131

Beijing, , China

Op0002 20157

Beijing, , China

Op0002 20021

Chengdu, , China

Op0002 20133

Chengdu, , China

Op0002 20137

Chengdu, , China

Op0002 20205

Foshan, , China

Op0002 20117

Guangzhou, , China

Op0002 20124

Guangzhou, , China

Op0002 20209

Nanchang, , China

Op0002 20135

Nanjing, , China

Op0002 20202

Pingxiang, , China

Op0002 20199

Rui’an, , China

Op0002 20116

Shanghai, , China

Op0002 20118

Shanghai, , China

Op0002 20121

Shanghai, , China

Op0002 20123

Shanghai, , China

Op0002 20129

Shanghai, , China

Op0002 20119

Suzhou, , China

Op0002 20204

Suzhou, , China

Op0002 20122

Tianjin, , China

Op0002 20136

Tianjin, , China

Op0002 20120

Wuhan, , China

Op0002 20134

Yueyang, , China

Op0002 20132

Zhengzhou, , China

Countries

China

Provided Documents

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

OP0002

Identifier Type: -

Identifier Source: org_study_id