Pharmacokinetics of Ceftriaxone Free Fraction

NCT ID: NCT05061875

Last Updated: 2021-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-03-01

Study Completion Date

2022-02-01

Brief Summary

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Prospective observational follow-up study for the study and modeling of the pharmacokinetics of the free fraction of ceftriaxone in patients treated with high doses of ceftriaxone (greater than or equal to 4 grams per day).

Detailed Description

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A prospective follow-up observational study to study and model the pharmacokinetics of the ceftriaxone free fraction in patients treated with high doses of ceftriaxone (greater than or equal to 4 grams per day). it is a pilot study that has between 10 and 20 patients. This study will not condition the treatment of patients at any time.

The samples will be processed after their extraction. The concentration of the samples will be analyzed using a high-performance gilent infinity liquid chromatograph coupled to a mass spectrometer using positive or negative ionization using electrospray.

Conditions

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Ceftriaxone Poisoning

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Cases

Patients treated with ceftriaxone doses equal to or higher 4 grams / day.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Men or women over 55 years of age receiving treatment with high-dose ceftriaxone (minimum 4 grams / day) for any clinical indication in the study period.
* Creatinine \<1.5 mg / dL
* The patient must have received at least 48 hours of treatment with the same previous therapeutic regimen to extraction.
* The subject or her representative must give their verbal or written consent to participate in the study. East Consent can be revoked at any time without prejudice to the patient.

The consent it will be recorded in your medical record.

Exclusion Criteria

* Patients under 55 years of age.
* Creatinine\> 1.5 mg / dL
* Patient with less than 48 hours of treatment with high-dose ceftriaxone.
* Subjects with allergy or hypersensitivity to cephalosporins and penicillins.
* Subjects who do not grant or withdraw their consent.
* Patients whose concomitant treatment presents possible interactions with the study medication. The possible interactions will be evaluated by staff of the Pharmacy Service.
Minimum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Maria Victoria Gil Navarro

Role: PRINCIPAL_INVESTIGATOR

Hospitales Universitarios Virgen del Rocío

Locations

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Hospital Universitario Virgen del Rocío

Seville, , Spain

Site Status RECRUITING

Countries

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Spain

Central Contacts

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Maria Victoria Gil Navarro

Role: CONTACT

Phone: 955012300

Email: [email protected]

Carlos García Pérez

Role: CONTACT

Phone: 955 04 31 27

Email: [email protected]

Facility Contacts

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Maria Victoria Gil Navarro

Role: primary

Other Identifiers

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FIS-CEF-2021-01

Identifier Type: -

Identifier Source: org_study_id