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Routine Transcervical Thymectomy in MEN-1 Patients

NCT ID: NCT05061784

Last Updated: 2021-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

7 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-14

Study Completion Date

2021-08-20

Brief Summary

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A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.

Detailed Description

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Introduction and Importance Malignant thymic carcinoids are uncommon but important entities among patients with multiple endocrine neoplasia type 1 (MEN-1). Current treatment guidelines advise the performance of a routine transcervical thymectomy (TCT) during parathyroidectomy, to prevent its development, although data on the yield of this prophylactic TCT is scarce. We aimed to revisit available literature to investigate and summarize the efficacy of routine TCT during neck exploration for parathyroidectomy, for the prevention of thymic carcinoid tumours among MEN-1 patients.

Methods A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.

Conditions

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Multiple Endocrine Neoplasia Type 1 (MEN-1) Thymic Carcinoid

Keywords

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Routine transcervical thymectomy

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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MEN-1 patients who underwent routine thymectomy during parathyroidecotmy

A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.

Routine thymectomy, which has been performed

Intervention Type PROCEDURE

There is no intervention

Interventions

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Routine thymectomy, which has been performed

There is no intervention

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Studies including MEN-1 patients who underwent a routine thymectomy during parathyoidectomy

* We accepted randomized controlled trials or observational studies that included patients of any age who underwent a routine TCT in the setting for MEN-1, published as full-length articles in peer-reviewed journals, which mentioned data on thymic carcinoid tumours.

Exclusion Criteria

* We excluded reviews, letters, conference proceedings and non-English publications.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National University Health System, Singapore

OTHER

Sponsor Role lead

Responsible Party

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Rajeev Parameswaran

Assistant Professor and Head & Senior Consultant

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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National University Hospital

Singapore, , Singapore

Site Status

Countries

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Singapore

Other Identifiers

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exempt from review

Identifier Type: -

Identifier Source: org_study_id