A Study to Assess the Efficacy and Safety of AXS-12 (Reboxetine) in Patients With Narcolepsy

NCT ID: NCT05059223

Last Updated: 2025-03-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-09-15

Study Completion Date

2024-03-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study is a multi-center, double-blind, placebo-controlled, randomized Phase 3 trial to assess the safety and efficacy of AXS-12 in narcoleptic subjects with cataplexy and excessive daytime sleepiness (EDS).

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Eligible subjects must have a diagnosis of narcolepsy per the International Classification of Sleep Disorders (ICSD-3), and exhibit symptoms of both cataplexy and EDS. Subjects meeting the entry criteria will be randomized in a 1:1 ratio to receive either AXS-12 or placebo for five weeks.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Narcolepsy Cataplexy Excessive Daytime Sleepiness

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

AXS-12 (reboxetine)

Up to 5 weeks

Group Type EXPERIMENTAL

AXS-12 (reboxetine)

Intervention Type DRUG

AXS-12 tablets, taken twice daily

Placebo

Up to 5 weeks

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo tablets, taken twice daily

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

AXS-12 (reboxetine)

AXS-12 tablets, taken twice daily

Intervention Type DRUG

Placebo

Placebo tablets, taken twice daily

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Male or female subjects between 15 and 75 years of age, inclusive
* Primary diagnosis of narcolepsy with cataplexy
* Willing and able to comply with the study requirements

Exclusion Criteria

* Other clinically significant conditions potentially causing EDS
* Clinically significant psychiatric disorders
Minimum Eligible Age

15 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Axsome Therapeutics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Clinical Research Site

Alabaster, Alabama, United States

Site Status

Clinical Research Site

Peoria, Arizona, United States

Site Status

Clinical Research Site

Phoenix, Arizona, United States

Site Status

Clinical Research Site

Redwood City, California, United States

Site Status

Clinical Research Site

San Diego, California, United States

Site Status

Clinical Research Site

Santa Ana, California, United States

Site Status

Clinical Research Site

Santa Monica, California, United States

Site Status

Clinical Research Site

Boulder, Colorado, United States

Site Status

Clinical Research Site

Colorado Springs, Colorado, United States

Site Status

Clinical Research Site

Brandon, Florida, United States

Site Status

Clinical Research Site

Clearwater, Florida, United States

Site Status

Clinical Research Site

Doral, Florida, United States

Site Status

Clinical Research Site

Kissimmee, Florida, United States

Site Status

Clinical Research Site

Miami, Florida, United States

Site Status

Clinical Research Site

Miami Lakes, Florida, United States

Site Status

Clinical Research Site

St. Petersburg, Florida, United States

Site Status

Clinical Research Site

Tampa, Florida, United States

Site Status

Clinical Research Site

Winter Park, Florida, United States

Site Status

Clinical Research Site

Atlanta, Georgia, United States

Site Status

Clinical Research Site

Atlanta, Georgia, United States

Site Status

Clinical Research Site

Gainesville, Georgia, United States

Site Status

Clinical Research Site

Macon, Georgia, United States

Site Status

Clinical Research Site

Stockbridge, Georgia, United States

Site Status

Clinical Research Site

Honolulu, Hawaii, United States

Site Status

Clinical Research Site

Peoria, Illinois, United States

Site Status

Clinical Research Site

Fort Wayne, Indiana, United States

Site Status

Clinical Research Site

Chevy Chase, Maryland, United States

Site Status

Clinical Research Site

Newton, Massachusetts, United States

Site Status

Clinical Research Site

North Dartmouth, Massachusetts, United States

Site Status

Clinical Research Site

Kalamazoo, Michigan, United States

Site Status

Clinical Research Site

Novi, Michigan, United States

Site Status

Clinical Research Site

Maplewood, Missouri, United States

Site Status

Clinical Research Site

Las Vegas, Nevada, United States

Site Status

Clinical Research Site

West Long Branch, New Jersey, United States

Site Status

Clinical Research Site

Brooklyn, New York, United States

Site Status

Clinical Research Site

New Hyde Park, New York, United States

Site Status

Clinical Research Site

Denver, North Carolina, United States

Site Status

Clinical Research Site

Gastonia, North Carolina, United States

Site Status

Clinical Research Site

Huntersville, North Carolina, United States

Site Status

Clinical Research Site

Cincinnati, Ohio, United States

Site Status

Clinical Research Site

Wyomissing, Pennsylvania, United States

Site Status

Clinical Research Site

Charleston, South Carolina, United States

Site Status

Clinical Research Site

Columbia, South Carolina, United States

Site Status

Clinical Research Site

Austin, Texas, United States

Site Status

Clinical Research Site

San Antonio, Texas, United States

Site Status

Clinical Research Site

Sugar Land, Texas, United States

Site Status

Clinical Research Site

Williamsburg, Virginia, United States

Site Status

Clinical Research Site

Markham, Ontario, Canada

Site Status

Clinical Research Site

Toronto, Ontario, Canada

Site Status

Clinical Research Site

Toronto, Ontario, Canada

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Canada

Related Links

Access external resources that provide additional context or updates about the study.

http://SYMPHONYstudy.com

SYMPHONY Study Website

http://www.axsome.com

Axsome Therapeutics Website

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

AXS-12-301

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.