An Open Label Study of NLS-2 (Mazindol Extended Release) in Subjects With Narcolepsy

NCT ID: NCT05055024

Last Updated: 2023-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-10-26

Study Completion Date

2023-01-19

Brief Summary

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This is a multicenter, open-label extension of the clinical study NLS-1021, evaluating long-term safety, tolerability, pharmacokinetics (PK), and therapeutic response to treatment with NLS-2 in adult subjects with narcolepsy.

Detailed Description

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Conditions

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Narcolepsy With Cataplexy Narcolepsy Narcolepsy Without Cataplexy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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NLS-2 (mazindol extended release)

NLS-2 (mazindol extended release) administered once a day.

Group Type EXPERIMENTAL

Mazindol

Intervention Type DRUG

Drug: NLS-2

Interventions

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Mazindol

Drug: NLS-2

Intervention Type DRUG

Other Intervention Names

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NLS-2 mazindol extended release

Eligibility Criteria

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Inclusion Criteria

* The subject must complete all Study NLS-1021 study requirements and assessments up to Visit 6;
* The subject is able, in the opinion of the Investigator, to receive NLS-2 for the 24-week Treatment Phase of this study;
* Biological females of childbearing potential must agree to use a medically acceptable double-barrier method of contraception for at least 30 days prior to Day 1 and until completion of the study;
* The subject is able to comply with the open-labelled extension design schedule and other study requirements;
* The subject provides written informed consent for the open-label extension study.

Exclusion Criteria

* The subject receives any investigational drug (other than the COVID-19 vaccine) that is not NLS-2.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NLS Pharmaceutics

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Carlos Camozzi, MD

Role: STUDY_DIRECTOR

NLS Pharmaceutics

Locations

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Sleep Disorders Center of Alabama

Birmingham, Alabama, United States

Site Status

Stanford Sleep Medicine Center

Redwood City, California, United States

Site Status

Pacific Research Network

San Diego, California, United States

Site Status

St. Francis Sleep Allergy and Lung Institute

Clearwater, Florida, United States

Site Status

Sleep Medicine Specialists of South Florida

Miami, Florida, United States

Site Status

Ivetmar Medical Group

Miami, Florida, United States

Site Status

The Angel Medical Research Corporation

Miami Lakes, Florida, United States

Site Status

Treken Primary care

Atlanta, Georgia, United States

Site Status

NeuroTrials Research

Atlanta, Georgia, United States

Site Status

Clinical Research Institute

Stockbridge, Georgia, United States

Site Status

Hawaii Pacific Neuroscience Clinical Research Center

Honolulu, Hawaii, United States

Site Status

The Center For Sleep & Wake Disorders

Chevy Chase, Maryland, United States

Site Status

Sleep and Attention Disorders

Sterling Heights, Michigan, United States

Site Status

Neurology and Sleep Disorders Clinic

Columbia, Missouri, United States

Site Status

Carolinas Sleep Specialists

Concord, North Carolina, United States

Site Status

Superior Clinical Research, LLC

Goldsboro, North Carolina, United States

Site Status

Advanced Respiratory and Sleep Medicine

Huntersville, North Carolina, United States

Site Status

Intrepid Research

Cincinnati, Ohio, United States

Site Status

Ohio Sleep Medicine Institute

Dublin, Ohio, United States

Site Status

Bogan Sleep Consultants

Columbia, South Carolina, United States

Site Status

Dharma PA d/b/a Southwest Family Medicine Associates

Dallas, Texas, United States

Site Status

Sleep Therapy & Research Center

San Antonio, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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NLS-1022

Identifier Type: -

Identifier Source: org_study_id

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