Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
81 participants
OBSERVATIONAL
2020-07-29
2023-08-29
Brief Summary
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The investigators hypothesize that in patients with OSA, blood tests will be better than 24-hr urine tests at ruling out a tumour. If this is confirmed, then OSA patients with suspected phaeochromocytoma could be investigated with a morning blood test instead of a traditional urine test, reducing unnecessary additional tests and patient anxiety.
In this single site study, the investigators plan to recruit 70 patients undergoing polysomnography. 24hr urine and bloods will be measured. Patients with elevated hormone levels will undergo imaging to rule out a tumour.
The primary outcome will be the accuracy of each test in ruling out a tumour. The secondary outcomes will be the relationship between stress hormone level and severity of OSA, which may help to explain the increased cardiovascular risk in patients with OSA, and the change in stress hormone level with treatment for OSA
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Obstructive Sleep Apnoea (OSA)
Subjects with OSA
Measurement of Urine and plasma metanephrines
Measurement of Urine and plasma metanephrines
Elevated Urine Metanephrines
Subjects with elevated metanephrines
Measurement of Urine and plasma metanephrines
Measurement of Urine and plasma metanephrines
Interventions
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Measurement of Urine and plasma metanephrines
Measurement of Urine and plasma metanephrines
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Other factors that can cause changes in metanephrine levels
* Renal impairment (eGFR \< 60ml/min)
* Other serious medical conditions
21 Years
70 Years
ALL
Yes
Sponsors
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Changi General Hospital
OTHER
Responsible Party
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Locations
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Changi General Hospital
Singapore, , Singapore
Countries
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Other Identifiers
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OSA_Mets
Identifier Type: -
Identifier Source: org_study_id
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