Mitoxantrone Hydrochloride Liposome Injection, Bortezomib and Dexamethasone in the Treatment of R/R MM

NCT ID: NCT05052970

Last Updated: 2022-02-01

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE1
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-10-20
• Study Completion Date: 2024-06-20

Brief Summary

The purpose of this study is to evaluate the safety and efficacy of mitoxantrone hydrochloride liposome injection in combination with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma.

Detailed Description

This is a multicenter, open-label, phase I study aimed to evaluate the safety and efficacy of mitoxantrone hydrochloride liposome injection in combination with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma. In the study, 60 patients will be recruited into three dose groups. All patients will receive the treatment for the planned 8 cycles(28 days per cycle）until disease progression or unacceptable drug-related adverse events

Conditions

Relapsed or Refractory Multiple Myeloma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

12 mg/m ^ 2 dose group (ArmA)

Patients with relapsed or refractory multiple myeloma will receive mitoxantrone hydrochloride liposome in combination with bortezomib and dexamethasone for 8 cycles (planned) (28 days per cycle). The dose of mitoxantrone hydrochloride liposome is 12 mg/m\^2

Group Type: EXPERIMENTAL

Mitoxantrone Hydrochloride Liposome injection

Intervention Type: DRUG

Mitoxantrone Hydrochloride Liposome injection will be administered by an intravenous infusion on day 1 of each 28-day cycle

Bortezomib for Injection

Intervention Type: DRUG

Bortezomib (1.3 mg/m\^2) will be administered by an intravenous injection or subcutaneously on day 1,4,8,11of each 28-day cycle

Dexamethasone Acetate Tablets

Intervention Type: DRUG

Dexamethasone (20 mg/d) will be taken orally on day 1,2,4,5,8,9,11,12 of each 28-day cycle

16 mg/m ^ 2 dose group (ArmB)

Patients with relapsed or refractory multiple myeloma will receive mitoxantrone hydrochloride liposome in combination with bortezomib and dexamethasone for 8 cycles (planned) (28 days per cycle). The dose of mitoxantrone hydrochloride liposome is 16 mg/m\^2

Group Type: EXPERIMENTAL

Mitoxantrone Hydrochloride Liposome injection

Intervention Type: DRUG

Mitoxantrone Hydrochloride Liposome injection will be administered by an intravenous infusion on day 1 of each 28-day cycle

Bortezomib for Injection

Intervention Type: DRUG

Bortezomib (1.3 mg/m\^2) will be administered by an intravenous injection or subcutaneously on day 1,4,8,11of each 28-day cycle

Dexamethasone Acetate Tablets

Intervention Type: DRUG

Dexamethasone (20 mg/d) will be taken orally on day 1,2,4,5,8,9,11,12 of each 28-day cycle

20 mg/m ^ 2 dose group (ArmC)

Patients with relapsed or refractory multiple myeloma will receive mitoxantrone hydrochloride liposome in combination with bortezomib and dexamethasone for 8 cycles (planned) (28 days per cycle). The dose of mitoxantrone hydrochloride liposome is 20 mg/m\^2

Group Type: EXPERIMENTAL

Mitoxantrone Hydrochloride Liposome injection

Intervention Type: DRUG

Mitoxantrone Hydrochloride Liposome injection will be administered by an intravenous infusion on day 1 of each 28-day cycle

Bortezomib for Injection

Intervention Type: DRUG

Bortezomib (1.3 mg/m\^2) will be administered by an intravenous injection or subcutaneously on day 1,4,8,11of each 28-day cycle

Dexamethasone Acetate Tablets

Intervention Type: DRUG

Dexamethasone (20 mg/d) will be taken orally on day 1,2,4,5,8,9,11,12 of each 28-day cycle

Interventions

Mitoxantrone Hydrochloride Liposome injection

Mitoxantrone Hydrochloride Liposome injection will be administered by an intravenous infusion on day 1 of each 28-day cycle

Intervention Type: DRUG

Bortezomib for Injection

Bortezomib (1.3 mg/m\^2) will be administered by an intravenous injection or subcutaneously on day 1,4,8,11of each 28-day cycle

Intervention Type: DRUG

Dexamethasone Acetate Tablets

Dexamethasone (20 mg/d) will be taken orally on day 1,2,4,5,8,9,11,12 of each 28-day cycle

Intervention Type: DRUG

Other Intervention Names

Mitoxantrone Hydrochloride Liposome; Bortezomib; Dexamethasone

Eligibility Criteria

Inclusion Criteria

1. Patients fully understand and voluntarily participate in this study and sign informed consent;

2. Aged 18-75 years, without gender limitation;

3. Patients with relapsed or refractory multiple myeloma(confirmed by histologically or cytologically) who had received at least one prior line regular treatment;

4. Patients have at least one of the following conditions:（1）Serum M protein≥10g/L;（2）Urine M protein≥200 mg/24h; （3）Serum free light chain(sFLC): κ/λ FLC ratio is abnormal and affected FLC ≥100mg /L

5. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2;

6. Laboratory tests meet the following conditions:

• Absolute neutrophil count (ANC) ≥1.5x10^9/L (No G-CSF treatment within 1 week prior to the laboratory test);
• Platelet count ≥ 75x10^9/L (No platelet transfusion within 1 week prior to the laboratory test);
• Total bilirubin ≤1.5upper limit of normal (ULN);
• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 ULN;
• Creatinine clearance(Ccr) ≥30mL/min.

7. Females of childbearing potential must have a negative serum beta human chorionic gonadotrophin (β-hCG) pregnancy test result prior to enrollment and must agree to use an effective contraception method for the duration of the study treatment and 7 months after the last dose of study therapy.

8. Males patients and their partners must agree to use an effective contraceptive method for the duration of the study treatment and 4 months after the last dose of study therapy.

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Exclusion Criteria

1. Patients with amyloidosis or central nervous system invasion or on dialysis treatment.

2. Life expectancy < 3 months.

3. History of allergy to mitoxantrone hydrochloride or liposomes；or previous treatment with adriamycin or other anthracyclines, with the total cumulative dose (doxorubicin equivalent) ≥350 mg/m^2.

4. History of allergy (except local injection reaction) or intolerance to bortezomib；or one of the following conditions occurred with prior bortezomib regimens: no treatment response (not reach MR)，disease progression within 6 months after the end of last dose.

5. History of contraindications or intolerance to dexamethasone.

6. Any anti-myeloma drug treatment or radiotherapy within 4 weeks prior to the first dose; or enrolled in any other clinical trials of anti-myeloma drug within 3 months prior to the first dose.

7. History of autologous hematopoietic stem cell transplantation within 6 months prior to screening.

8. History of allogeneic hematopoietic stem cell transplantation or solid organ transplantation.

9. Adverse events from the previous treatment have not resolved to ≤ Grade 1 (except for alopecia, hyperpigmentation).

10. Patients with persistent Grade≥2 peripheral neuropathy or Grade 1 peripheral neuropathy with pain.

11. Patients with impaired cardiac function or significant cardiac disease.

12. HBsAg/HBcAb positive with HBV-DNA titer higher than the lower limit of the test value of the research center, or HCV antibody positive with HCV-RNA titer higher than the lower limit of the test value of the research center,or human immunodeficiency virus (HIV) antibody positive.

13. Patients with obvious digestive system dysfunction, which may affect intake, transport and absorption of the study drug.

14. Active bacterial, fungal or viral infections that require systemic treatment within 1 week prior to the first dose

15. Patients underwent major surgery within 6 weeks prior to the first dose, or had a surgical schedule during the study period;

16. History of additional malignant tumor within 5 years, except for locally curable cancer that has been cured.

17. Other medical conditions that, in the judgment of the investigator, may affect the patient's participation in this study.

18. Pregnant or breastfeeding women;

19. Not suitable for this study as decided by the investigator due to other reasons.

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• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Wenming Chen

Role: PRINCIPAL_INVESTIGATOR

Beijing Chao Yang Hospital

Locations

Beijing Chaoyang Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Na An

Role: CONTACT

anna@mail.ecspc.com

+86-010-63930582

Facility Contacts

Wenming Chen, Doctor

Role: primary

13910107759@163.com

13910107759

References

Zhou YL, Zhang JQ, Wang W, Bao L, Fang BJ, Gao D, Su LP, Chen WM, Yang GZ. Bortezomib, Mitoxantrone Hydrochloride Liposome, and Dexamethasone for Relapsed/Refractory Multiple Myeloma: A Multi-Center, Open-Label Phase I Trial. Cancer Med. 2025 Apr;14(8):e70890. doi: 10.1002/cam4.70890.

Reference Type: DERIVED

PMID: 40232151 (View on PubMed)

Other Identifiers

HE071-CSP-023

Identifier Type: -

Identifier Source: org_study_id