PROSA: Prolactin, Sex Hormones, Growth and Metabolic Biomarkers in Children and Adolescents on Antipsychotics

NCT ID: NCT05033119

Last Updated: 2024-08-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-11-01

Study Completion Date

2024-10-31

Brief Summary

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The objectives of this study are:

1. To determine the prevalence and degree of hyperprolactinemia in children and adolescents aged 7-18 years receiving antipsychotic medications
2. To determine the associations between serum-prolactin and sex hormones / metabolic biomarkers/ clinical symptoms in this population. If clinically relevant associations are found: To determine a potentially existing "no harm" serum-prolactin threshold
3. To determine associations between previous cumulative prolactin-exposure and current pubertal development / growth

Detailed Description

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Conditions

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Hyperprolactinemia Puberty Disorders Metabolic Syndrome Growth Disorders Antipsychotics and Neuroleptics Toxicity

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* • In daily treatment with antipsychotic medication belonging to Anatomical Therapeutic Chemical (ATC) group N05A (except N05AN lithium) for a minimum duration of 3 months prior to inclusion

Exclusion Criteria

* Eating Disorder
* Medical treatment to change sex
* Pregnancy or lactation
Minimum Eligible Age

7 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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North Denmark Region

OTHER_GOV

Sponsor Role collaborator

Central Denmark Region

OTHER

Sponsor Role collaborator

Mental Health Services in the Capital Region, Denmark

OTHER

Sponsor Role collaborator

Ulla Schierup Nielsen

OTHER

Sponsor Role lead

Responsible Party

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Ulla Schierup Nielsen

National Coordinating Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Ulla S Nielsen

Role: STUDY_DIRECTOR

Research Unit for Child and Adolescent Psychiatry, Aalborg,

Locations

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Research Unit for Child and Adolescent Psychiatry, Aalborg University Hospital, Denmark

Aalborg, , Denmark

Site Status

Aarhus University Hospital

Aarhus, , Denmark

Site Status

Child and Adolescent Mental Health Center Capital Region, Denmark

Copenhagen, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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N-20210029

Identifier Type: -

Identifier Source: org_study_id

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