The Effect of Central Sensitization on Treatment Response in Patients With Fibromyalgia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-08-19

Study Completion Date

2024-12-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Central sensitization (CS) is as increased response to normal or sub-threshold stimuli of central nervous system and its close relationship with fibromyalgia has been demonstrated in several studies. However, the effect of initial CS severity on treatment response in these patients is not fully known. In this study, it was aimed to investigate the severity of CS and its effect on treatment response in patients with fibromyalgia.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Relationship Between Neuropathic Complaints and Central Sensitization in Fibromyalgia

NCT05701696

Central Sensitisation Fibromyalgia Neuropathic Pain

UNKNOWN

Relationship Between Central Sensitization Symptoms and Cognitive Dysfunction in Fibromyalgia

NCT06948903

Fibromyalgia Cognitive Dysfunction Central Sensitisation

RECRUITING

Evaluation of Chronotype and Central Sensitization in Patients With Fibromyalgia Syndrome

NCT06197087

Chronotype Fibromyalgia Syndrome

RECRUITING

Fibromyalgia Syndrome on Patients With Chronic Migraine

NCT05381012

Chronic Migraine, Headache Fibromyalgia Syndrome Chronic Pain Syndrome +2 more

COMPLETED NA

Pain Phenotypes in Patients with Fibromyalgia Syndrome

NCT05941780

Fibromyalgia, Primary Fibromyalgia Chronic Pain Syndrome +3 more

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Fibromyalgia is a disease characterized by chronic widespread pain and its etiology and pathophysiology are still unknown.It is considered to be the main member of the central sensitization-related disease group known as central sensitivity syndromes with impaired pain regulation.In various studies, hyperalgesia and allodynia, which are accepted as objective findings of central sensitization in patients with fibromyalgia, strengthen the relationship between fibromyalgia and central sensitization. The central sensitization inventory (CSI) was developed in 2012 to be used in the recognition of central sensitivity syndromes in patients with fibromyalgia. A score of 40 and above is accepted in favor of central sensitization in the scale, which consists of two parts, in which central sensitization-related symptoms and diagnoses are questioned; scores of 30-39 are classified as mild, 40-49 moderate, 50-59 severe, and 60-100 very severe. Parallel to the increase in the CSI score, an increase is observed in patients' pain severity, disability, depressive symptoms and sleep disorders.In addition, it has been reported in the literature that factors such as pre-treatment pain severity and depression affect the treatment response.Considering all these factors, it is possible that there is a relationship between the severity of central sensitization and treatment response in patients with fibromyalgia.Based on this, in this study, it was aimed to investigate the effect of central sensitization severity, which was evaluated with CSI before treatment, on the treatment process.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Central Sensitisation Fibromyalgia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.