Enhanced CBTi for Older Adult Sleep and Cognition

NCT ID: NCT05015803

Last Updated: 2024-04-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-03-16

Study Completion Date

2023-08-16

Brief Summary

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This randomized clinical trial on 60+ aged and independent-living healthy individuals with symptoms of insomnia will attempt to improve sleep and health outcomes related to sleep with enhancement of a clinical intervention, Cognitive Behavioral Therapy for Insomnia (CBTi).

Detailed Description

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Telehealth-delivered enhanced CBTi (integrated with a sleep diary app, a therapist dashboard, and data from IoT devices) will be compared to standard telehealth CBTi and to usual treatment with sleep hygiene education. The investigators will determine effects on insomnia (primary outcome) and on clinical sleep metrics (secondary outcome), among other outcomes including cognitive performance, blood biomarkers of ADRD, and therapeutic adherence.

After screening consent and qualification, informed consent, and adherence evaluation with ambulatory devices (1wk), study participants are pseudo-randomized into one of 3 study arms (2:2:1, Enhanced CBTi : Standard CBTi : Sleep Hygiene). The living space of participants is equipped with IoT data collection devices. Participants take surveys related to sleep, have blood drawn, wear ambulatory devices, complete cognitive evaluations, and interact with nearable living space devices and an iPhone interface during a preparation week leading up to an intake telehealth appointment. Baseline data collection (1wk) occurs. Participants then adhere to behavioral therapy directives prescribed at weekly telehealth sessions with a clinically qualified therapist, take surveys related to sleep, complete cognitive evaluations, wear ambulatory devices, and interact with nearable living space devices and an iPhone interface throughout the study intervention period of 6 weeks. During the final week (coinciding with the 6th intervention week), participants have a second blood draw and return all study equipment/devices at the conclusion of participation.

Conditions

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Insomnia Alzheimers Disease Related Dementias

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

CBTi with Application, Standard TeleHealth CBTi, and Sleep Hygiene Education study groups run in parallel after randomization.
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants
This is a single-blind study design. The therapeutic care for insomnia is synonymous with the study intervention, therefore blinding of the CBT care provider is impossible.

Study Groups

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CBTi with Application

Device-based intervention facilitation and clinician interfacing for Cognitive Behavioral Therapy for Insomnia (CBTi).

Group Type EXPERIMENTAL

CBTi with Application

Intervention Type COMBINATION_PRODUCT

Participants randomized to this study arm will experience an attempted enhancement of standard video conferencing CBTi, that is facilitated with electronic device-based data and resources to the clinician. Noninvasive ambulatory worn and nearable devices deliver feedback of data to the clinician on an application interface. This information will be used to inform the therapeutic approach and to facilitate a living-space environment that is conducive to effective therapy.

CBTi

Standard CBTi delivered via video conferencing \[Zoom Health\].

Group Type ACTIVE_COMPARATOR

CBTi

Intervention Type BEHAVIORAL

Participants randomized to this study arm will experience standard CBTi that is delivered via video conferencing by a clinician, with some application interface use.

Sleep Hygiene

Treatment as usual: Sleep hygiene education and training.

Group Type ACTIVE_COMPARATOR

Sleep Hygiene Education

Intervention Type BEHAVIORAL

Participants randomized to this study arm will experience sleep hygiene education and training, with some application interface use.

Interventions

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CBTi with Application

Participants randomized to this study arm will experience an attempted enhancement of standard video conferencing CBTi, that is facilitated with electronic device-based data and resources to the clinician. Noninvasive ambulatory worn and nearable devices deliver feedback of data to the clinician on an application interface. This information will be used to inform the therapeutic approach and to facilitate a living-space environment that is conducive to effective therapy.

Intervention Type COMBINATION_PRODUCT

CBTi

Participants randomized to this study arm will experience standard CBTi that is delivered via video conferencing by a clinician, with some application interface use.

Intervention Type BEHAVIORAL

Sleep Hygiene Education

Participants randomized to this study arm will experience sleep hygiene education and training, with some application interface use.

Intervention Type BEHAVIORAL

Other Intervention Names

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Cognitive-Behavioral Therapy for Insomnia - Enhanced Cognitive-Behavioral Therapy for Insomnia - Standard

Eligibility Criteria

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Inclusion Criteria

* Fluent English speaker/reader
* Resident of the state/commonwealth of Pennsylvania for tax purposes
* Ability to complete (sign) own consent form
* Age 60-90 (inclusive, at enrollment)
* Independent Living status (or equivalent; if dwelling in a community living facility)
* Insomnia Severity Index (ISI) screening survey score of \>=11
* Willing to refrain from initiating new therapeutic insomnia interventions that are not a part of this study protocol for the duration of study participation
* Willing to maintain existing physician-directed intervention for issues pertaining to sleep for the duration of study participation
* Has a residence with access to WiFi

Exclusion Criteria

* Has a pacemaker
* Illicit drug use in the past month
* Diagnosed serious mental health disorder (e.g. psychosis or bipolar depression)
* Currently engaged in evidence-based psychotherapy for Insomnia (e.g. CBTi)
* Cohabiting with a current or previous participant in this study
* Evidence of Cognitive Impairment (a score of \<18 on the abbreviated Montreal Cognitive Assessment \[MoCA\] screening evaluation)
Minimum Eligible Age

60 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Arizona

OTHER

Sponsor Role collaborator

Proactive Life Inc

INDUSTRY

Sponsor Role collaborator

Penn State University

OTHER

Sponsor Role lead

Responsible Party

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Orfeu M. Buxton

Elizabeth Fenton Susman Professor of Biobehavioral Health

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Daniel Taylor, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

The University of Arizona

Daniel Gartenberg, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Sleep Space, Inc.

Orfeu M Buxton, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

The Pennsylvania State University

Locations

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The Pennsylvania State University

University Park, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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R44AG056250

Identifier Type: NIH

Identifier Source: org_study_id

View Link

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