Study Results
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Basic Information
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COMPLETED
NA
45 participants
INTERVENTIONAL
2021-09-02
2025-04-23
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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Cardiac rehabilitation - High intensity interval training (HIIT)
Patients attending cardiac rehabilitation randomized to HIIT.
Cardiac rehabilitation - high intensity interval training (HIIT)
During cardiac rehabilitation (12-weeks, 3 sessions/week), exercise training will comprise of 4x4-min high intensity aerobic intervals at a rating of perceived exertion 15-17 (hard to very hard), interspersed by a 3-min active recovery at a rating of perceived exertion 11-13 (fairly light to somewhat hard). Warm-up (4-min) and cool-down (3-min) at a light intensity.
Cardiac rehabilitation - Moderate intensity continuous training (MICT)
Patients attending cardiac rehabilitation randomized to MICT.
Cardiac rehabilitation - moderate intensity continuous training (MICT)
During cardiac rehabilitation (12-weeks, 3 sessions/week), exercise training will comprise of 34-min of continuous aerobic exercise at a rating of perceived exertion 11-13 (fairly light to somewhat hard). Warm-up (3-min) and cool-down (3-min) at a light intensity.
Cardiac rehabilitation - control
The control group (12 week period) will include participants who have declined cardiac rehabilitation.
Cardiac rehabilitation - control
Participants will receive exercise advice in line with usual hospital discharge procedures. This involves exercise physiologists providing verbal and written information on achieving the national physical activity guidelines (150min/week of moderate intensity exercise) 60 and range of movement exercises for surgical patients with sternotomy. However, no structured or supervised exercise training program or other contact with participants will be provided after hospital discharge, to reflect the usual care process for patients that decline cardiac rehabilitation.
Healthy control group
Healthy age-matched adults without cardiovascular disease, who will complete baseline assessments only. No intervention period.
No interventions assigned to this group
Cardiac rehabilitation - observational
This observational group will include patients who are completing an exercise-based cardiac rehabilitation program in line with standard care but are not part of the randomized exercise protocol groups (HIIT or MICT). Participants in this group will be combined with HIIT and MICT (as exercise-based cardiac rehabilitation group) for Aims 1b and 2b.
Cardiac rehabilitation - observational
During cardiac rehabilitation (12-weeks), program frequency and exercise training protocol will align with clinical care decisions and/or patient choice rather than random assignment.
Interventions
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Cardiac rehabilitation - high intensity interval training (HIIT)
During cardiac rehabilitation (12-weeks, 3 sessions/week), exercise training will comprise of 4x4-min high intensity aerobic intervals at a rating of perceived exertion 15-17 (hard to very hard), interspersed by a 3-min active recovery at a rating of perceived exertion 11-13 (fairly light to somewhat hard). Warm-up (4-min) and cool-down (3-min) at a light intensity.
Cardiac rehabilitation - moderate intensity continuous training (MICT)
During cardiac rehabilitation (12-weeks, 3 sessions/week), exercise training will comprise of 34-min of continuous aerobic exercise at a rating of perceived exertion 11-13 (fairly light to somewhat hard). Warm-up (3-min) and cool-down (3-min) at a light intensity.
Cardiac rehabilitation - control
Participants will receive exercise advice in line with usual hospital discharge procedures. This involves exercise physiologists providing verbal and written information on achieving the national physical activity guidelines (150min/week of moderate intensity exercise) 60 and range of movement exercises for surgical patients with sternotomy. However, no structured or supervised exercise training program or other contact with participants will be provided after hospital discharge, to reflect the usual care process for patients that decline cardiac rehabilitation.
Cardiac rehabilitation - observational
During cardiac rehabilitation (12-weeks), program frequency and exercise training protocol will align with clinical care decisions and/or patient choice rather than random assignment.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Eligible for cardiac rehabilitation following a cardiac-related hospital admission, coronary artery disease (including angina, myocardial infarction, percutaneous coronary intervention, or coronary artery bypass graft surgery).
* Aged 40-years and older.
* Never been diagnosed with cardiovascular disease or coronary artery disease.
* No history of cardiovascular disease risk factors including hypertension, hyperlipidemia, diabetes, obesity (body mass index \> 30) or smoking.
* Current body mass index \< 30kg/m2
Exclusion Criteria
* Known moderate-severe respiratory disease, pregnancy,
* Orthopedic limitations affecting exercise capability
* Unable to read and speak English
* Unable to complete study-related activities
* Contraindications to hypercapnia
* Contraindications to maximal exercise testing
* MRI incompatible devices
* Unwillingness to undergo MRI scan (e.g. due to anxiety or claustrophobia).
* Known cerebrovascular or neurological disease
* Known moderate-severe respiratory disease, pregnancy,
* Unable to read and speak English
* Unable to complete study-related activities
* Contraindications to hypercapnia
* MRI incompatible devices
* Unwillingness to undergo MRI scan (e.g. due to anxiety or claustrophobia)
40 Years
ALL
Yes
Sponsors
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Mayo Clinic
OTHER
Responsible Party
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Bruce Johnson
Principal Investigator
Principal Investigators
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Bruce D Johnson, PhD
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, United States
Countries
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Other Identifiers
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20-010808
Identifier Type: -
Identifier Source: org_study_id
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