Study of STIM1 Membrane Expression

NCT ID: NCT04978948

Last Updated: 2025-02-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

670 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-05-11

Study Completion Date

2027-05-31

Brief Summary

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The aim of this study is to determine the expression of STIM1 in the plasma membrane of lymphocytes from patients suffering from different autoimmune diseases in order to identify new pathologies of interest presenting an over-expression of STIM1PM.

This would allow to initiate, following this study, research and development programs on the use of anti-STIM1 antibodies in these identified autoimmune diseases of interest.

Detailed Description

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Conditions

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Autoimmune Diseases

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Myasthénie

Blood samples will be collected

No interventions assigned to this group

Myopathie inflammatoire (Myosite)

Blood samples will be collected

No interventions assigned to this group

Neuropathie autoimmune

Blood samples will be collected

No interventions assigned to this group

Néphropathies autoimmunes

Blood samples will be collected

No interventions assigned to this group

Hépatite auto-immune

Blood samples will be collected

No interventions assigned to this group

Pancréatite auto-immune

Blood samples will be collected

No interventions assigned to this group

Purpura Thrombopénique Immunologique

Blood samples will be collected

No interventions assigned to this group

Dermatose bulleuse

Blood samples will be collected

No interventions assigned to this group

Thyroïdite autoimmune

Blood samples will be collected

No interventions assigned to this group

Sclérose en plaque

Blood samples will be collected

No interventions assigned to this group

Sclérose latérale amyotrophique

Blood samples will be collected

No interventions assigned to this group

Polyarthrite Rhumatoïde

Blood samples will be collected

No interventions assigned to this group

Spondylarthrite axiale

Blood samples will be collected

No interventions assigned to this group

controls

Patients without autoimune desease\* Blood samples will be collected

No interventions assigned to this group

Lichen plan buccal auto-immun (LPB)

Blood samples will be collected

No interventions assigned to this group

lichen plan buccal allo-immun liée à une GvHD (" Graft versus Host Disease ")

Blood samples will be collected

No interventions assigned to this group

Lupus érythémateux systémique

Blood samples will be collected

No interventions assigned to this group

Sclérodermie

Blood samples will be collected

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of one of the autoimmune diseases

Exclusion Criteria

* Treatment with rituximab in the previous 12 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Brest

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHRU de Brest - Service de rhumatologie

Brest, Brest, France

Site Status RECRUITING

Centre Hospitalier des Pays de Morlaix

Morlaix, Brittany Region, France

Site Status RECRUITING

Centre Hospitalier de Quimper

Quimper, Brittany Region, France

Site Status RECRUITING

CHU de Martinique

Fort-de-France, Martinique, France

Site Status RECRUITING

Countries

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France

Central Contacts

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Divi Cornec

Role: CONTACT

02 98 22 33 33

Facility Contacts

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Divi CORNEC

Role: primary

02 98 34 72 64

Catherine Le Henaff

Role: primary

Jeremy Keraen

Role: primary

Benoit Suzon

Role: primary

Other Identifiers

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STIMEX - 29BRC21.0025

Identifier Type: -

Identifier Source: org_study_id

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