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Alcohol Metabolism and Disease Risk in Asians

NCT ID: NCT04967599

Last Updated: 2024-12-24

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

360 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-18

Study Completion Date

2023-01-18

Brief Summary

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The primary pathway of alcohol metabolism involves two main enzymes, alcohol and aldehyde dehydrogenase. Several genes that encode these enzymes have variants that alter the rate of alcohol metabolism and increase levels of acetaldehyde. The variant ALDH2\*2 allele is associated with the flushing response (i.e., Asian glow) and is found almost exclusively in individuals of east Asian descent. Although having variant ALDH2 alleles is protective against heavy drinking and alcohol use disorders, for those who do drink, these variants also are associated with elevations in risk for several health problems. The premise of this study is that we can affect early drinking behavior through personalized communication about these health-related risks.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Control (CONTROL)

Participants do not receive PHEN or GENE.

Group Type NO_INTERVENTION

No interventions assigned to this group

Phenotype Feedback (PHEN)

Participants receive the PHEN intervention.

Group Type EXPERIMENTAL

Phenotype Feedback Intervention

Intervention Type BEHAVIORAL

Online session providing information on health-related risk associated with alcohol consumption and alcohol metabolism gene variations plus personalized feedback on flushing phenotype and associated risks.

Phenotype and Genotype Feedback (PHEN+GENE)

Participants receive the PHEN and GENE interventions.

Group Type EXPERIMENTAL

Phenotype Feedback Intervention

Intervention Type BEHAVIORAL

Online session providing information on health-related risk associated with alcohol consumption and alcohol metabolism gene variations plus personalized feedback on flushing phenotype and associated risks.

Genotype Feedback Intervention

Intervention Type BEHAVIORAL

Online session providing personalized feedback on alcohol metabolism genotypes and associated health-related risks.

Interventions

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Phenotype Feedback Intervention

Online session providing information on health-related risk associated with alcohol consumption and alcohol metabolism gene variations plus personalized feedback on flushing phenotype and associated risks.

Intervention Type BEHAVIORAL

Genotype Feedback Intervention

Online session providing personalized feedback on alcohol metabolism genotypes and associated health-related risks.

Intervention Type BEHAVIORAL

Other Intervention Names

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PHEN GENE

Eligibility Criteria

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Inclusion Criteria

* All participants will be of Asian heritage (i.e. Chinese/Taiwanese, Japanese, Korean, Vietnamese).
* About half of the sample will be incoming first-year undergraduates
* About half of the sample will be current undergraduates who self-report having flushed when they first started drinking alcohol
Minimum Eligible Age

17 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Southern California

OTHER

Sponsor Role lead

Responsible Party

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Susan Luczak

Professor (Research)

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Susan E. Luczak, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Southern California

Locations

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University of Southern California

Los Angeles, California, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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HS-20-00814

Identifier Type: -

Identifier Source: org_study_id