Role of Ivermectin Nanosuspension as Nasal Spray in Treatment of Persistant Post covid19 Anosmia

NCT ID: NCT04951362

Last Updated: 2022-04-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2/PHASE3

Total Enrollment

117 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-04-20

Study Completion Date

2022-05-15

Brief Summary

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ivermectin is FDA approaved antiparasitic drug which is also claimed to be having potent in vitro antiviral effect,so we are tryying to study itsovid19 anosmia effect upon releiving post covid19 anosmia

Detailed Description

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ivermectin is FDA approaved antiparasitic drug which is also claimed to be having potent in vitro antiviral effect,so we are tryying to study itsovid19 anosmia effect upon releiving post covid19 anosmia as one of the most characteresic symptoms of covid19 infection

Conditions

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Anosmia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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intranasal Ivermectin group

49 pateints with anosmia received ivermectin nanosuspension nasal spray

Group Type ACTIVE_COMPARATOR

intranasal spray ivermectin

Intervention Type DRUG

intranasal spray of saline

saline nasal spray

47 pateints with anosmia received saline nasal spray

Group Type PLACEBO_COMPARATOR

intranasal spray ivermectin

Intervention Type DRUG

intranasal spray of saline

Interventions

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intranasal spray ivermectin

intranasal spray of saline

Intervention Type DRUG

Other Intervention Names

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saline spray

Eligibility Criteria

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Inclusion Criteria

* post covid19 anosmia
* negative swab test for covid19

Exclusion Criteria

* other types of anosmia ,
* no local or central other causes of anosmia
* still active covid 19 pateints ( positive swab test )
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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South Valley University

OTHER

Sponsor Role lead

Responsible Party

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Zaky Aref

ass.professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Zaky Aref

Qina, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Zaky Aref, MD

Role: CONTACT

+201001771210

Facility Contacts

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Zaky Aref

Role: primary

01001771210

References

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Aref ZF, Bazeed SEES, Hassan MH, Hassan AS, Ghweil AA, Sayed MAA, Rashad A, Mansour H, Abdelmaksoud AA. Possible Role of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Recovery of Post-COVID-19 Anosmia. Infect Drug Resist. 2022 Sep 19;15:5483-5494. doi: 10.2147/IDR.S381715. eCollection 2022.

Reference Type DERIVED
PMID: 36164334 (View on PubMed)

Other Identifiers

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SVU MED CIT0 23 4 21 1 122

Identifier Type: -

Identifier Source: org_study_id

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