Mother's Recorded Voice Versus Dexmedetomidine on Postoperative Agitation

NCT ID: NCT04941508

Last Updated: 2021-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-06-25

Study Completion Date

2021-11-05

Brief Summary

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The aim of this study is to compare the efficacy of mother's recorded voice versus dexmedetomidine injection on postoperative agitation in children undergoing elective surgery.

Detailed Description

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A written informed consent will be taken from the patients' legal guardians.Patients will be assigned randomly to three groups (30 subjects each) to be anesthetized and either randomly assigned to listen to the mother's recorded voice at 2 times (in the holding area 3 minutes before induction of anesthesia till induction of anesthesia is ended) and (during emergence from anesthesia till complete recovery) (Group M) or will be given a single bolus of dexmedetomidine 0.2 µ/kg IV at 2 times (in the holding area 3 minutes before induction of anesthesia) and (at the end of surgery) (Group D) or given the same volume of saline IV at 2 times (in the holding area 3 minutes before induction of anesthesia) and (at the end of surgery) (Group C).To keep blinding, group M will be injected IV with the same volume of saline at the same 2 times as in groups D \& C while in groups D \& C, headphones will be putted as in group M at the same 2 times with no recorded voice.

Conditions

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Agitation, Emergence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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Mother's recorded voice

Children will be exposed to the mother's voice.

Group Type EXPERIMENTAL

the mother's recorded voice

Intervention Type BEHAVIORAL

Children will be assigned to listen to the mother's recorded voice at 2 times (in the holding area 3 minutes before induction of anesthesia till induction of anesthesia is ended) and (during emergence from anesthesia till complete recovery).

Dexmedetomidine IV

Children will be given dexmedetomidine injection.

Group Type EXPERIMENTAL

Dexmedetomidine

Intervention Type DRUG

Children will be given a single bolus of dexmedetomidine 0.2 µ/kg IV at 2 times (in the holding area 3 minutes before induction of anesthesia) and (at the end of surgery).

Saline placebo IV

Children will be given normal saline.

Group Type PLACEBO_COMPARATOR

saline 0.9% placebo

Intervention Type OTHER

Children will be given the same volume of saline at 2 times (in the holding area 3 minutes before induction of anesthesia) and (at the end of surgery).

Interventions

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the mother's recorded voice

Children will be assigned to listen to the mother's recorded voice at 2 times (in the holding area 3 minutes before induction of anesthesia till induction of anesthesia is ended) and (during emergence from anesthesia till complete recovery).

Intervention Type BEHAVIORAL

Dexmedetomidine

Children will be given a single bolus of dexmedetomidine 0.2 µ/kg IV at 2 times (in the holding area 3 minutes before induction of anesthesia) and (at the end of surgery).

Intervention Type DRUG

saline 0.9% placebo

Children will be given the same volume of saline at 2 times (in the holding area 3 minutes before induction of anesthesia) and (at the end of surgery).

Intervention Type OTHER

Other Intervention Names

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Precedex Normal saline

Eligibility Criteria

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Inclusion Criteria

* Children (age 4-9 years)
* American Society of Anesthesiologists physical status (ASA) I-II who will be listed for outpatient elective surgery under general anesthesia.

Exclusion Criteria

* Developmental delays
* Neurological diseases
* Deafness
* Hearing impairment
* Maternal mutism
* Absence of the mother
Minimum Eligible Age

4 Years

Maximum Eligible Age

9 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Omar Makram Soliman

Lecturer of anesthesia and ICU

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Omar Soliman, MD

Role: STUDY_DIRECTOR

Assiut University

Locations

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Assiut university hospital

Asyut, , Egypt

Site Status

Omar Soliman

Asyut, , Egypt

Site Status

Countries

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Egypt

References

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Manyande A, Cyna AM, Yip P, Chooi C, Middleton P. Non-pharmacological interventions for assisting the induction of anaesthesia in children. Cochrane Database Syst Rev. 2015 Jul 14;2015(7):CD006447. doi: 10.1002/14651858.CD006447.pub3.

Reference Type RESULT
PMID: 26171895 (View on PubMed)

Other Identifiers

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17300621

Identifier Type: -

Identifier Source: org_study_id