Integrative Oncology for Patient Symptoms

NCT ID: NCT04940780

Last Updated: 2023-11-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

750 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-01

Study Completion Date

2025-01-01

Brief Summary

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The use of complementary and integrative medicine (CIM) among oncology patients is widespread, with a large body of research-based evidence supporting the ability of these therapies to alleviate symptoms related to cancer and its treatment. Organizations such as the American Society for Clinical Oncology and the European Society for Medical Oncology have included CIM modalities in their treatment guidelines, and many of today's leading cancer centers include CIM in their supportive care service. The proposed study will prospectively examine the impact of a CIM treatment program on the symptom burden, quality of life and function of patients undergoing active oncology treatment.

A total of 750 patients will undergo an integrative oncologist (IP) consultation followed by a series of 8 CIM treatments consisting of either acupuncture or touch-related therapies (reflexology, Shiatsu, Tuina, etc.) with the goal of relieving their symptoms. Patients will be allocated to one of the two study treatment arms: the "Patient-Preference Arm", for patients who specify their preference for either acupuncture or touch therapy; and the "Randomized Treatment Arm", for those with no preference, to be randomly allocated to either the acupuncture or touch-therapy subgroup. Patients will be asked to complete the following study questionnaires before and after the treatment regimen: the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30); the Edmonton Symptom Assessment System (ESAS); and the Measure Yourself Concerns and Wellbeing (MYCAW) tool. The primary study outcome will be the change in EORTC Global Health-Status / Quality of Life scores, from pre- to post-treatment. Secondary study outcomes will include EORTC QLQ-C30 functional and symptom scales, single items assessing additional symptoms commonly reported by cancer patients, and perceived financial impact of the disease; ESAS severity scores for 10 quality-of life related items; and MYCAW severity scores for the 2 most significant symptoms, as well as post-treatment narratives. Other secondary outcomes to be assessed include the safety of the study treatments (adverse effects); adherence to conventional treatment regimen; and narratives from the patient's informal caregiver (spouse, parent/child, sibling, friend, etc.).

Detailed Description

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Conditions

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Oncologic Complications Symptoms and Signs

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Patient-preference, pragmatic methodology
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Patient Preference Arm

patients who specify their preference for either acupuncture or touch therapy

Group Type ACTIVE_COMPARATOR

Acupuncture

Intervention Type OTHER

Acupuncture points will be selected on an individualized and symptom-directed basis, with the incorporation of points shown in clinical research to be effective for specific symptoms

Touch Therapies

Intervention Type OTHER

Touch therapies are to include Reflexology, Shiatsu and Therapeutic Touch

Randomized Treatment Arm

with no preference, to be randomly allocated to either the acupuncture or touch-therapy subgroup

Group Type ACTIVE_COMPARATOR

Acupuncture

Intervention Type OTHER

Acupuncture points will be selected on an individualized and symptom-directed basis, with the incorporation of points shown in clinical research to be effective for specific symptoms

Touch Therapies

Intervention Type OTHER

Touch therapies are to include Reflexology, Shiatsu and Therapeutic Touch

Interventions

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Acupuncture

Acupuncture points will be selected on an individualized and symptom-directed basis, with the incorporation of points shown in clinical research to be effective for specific symptoms

Intervention Type OTHER

Touch Therapies

Touch therapies are to include Reflexology, Shiatsu and Therapeutic Touch

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* age ≥ 18 years
* undergoing active oncology treatment
* fully understand the study plan
* agree to sign the study informed consent form.

Exclusion Criteria

* not fulfilling all of the study criteria
* not interested in attending all 8 weekly CIM treatments sessions
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shaare Zedek Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Noah Samuels

Director, Center for Integrative Complementary Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Institute of Oncology, Shaare Zedek Medical Center

Jerusalem, , Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Noah Samuels, M.D.

Role: CONTACT

972-26666395

Facility Contacts

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Noah Samuels, M.D.

Role: primary

026666395

References

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Samuels N, Oberbaum M, Ben-Arye E. Expectations of Patients and Their Informal Caregivers from an Integrative Oncology Consultation. Integr Cancer Ther. 2021 Jan-Dec;20:1534735421990080. doi: 10.1177/1534735421990080.

Reference Type BACKGROUND
PMID: 33588610 (View on PubMed)

Samuels N, Ben-Arye E. Integrative Approaches to Chemotherapy-Induced Peripheral Neuropathy. Curr Oncol Rep. 2020 Feb 11;22(3):23. doi: 10.1007/s11912-020-0891-2.

Reference Type BACKGROUND
PMID: 32048067 (View on PubMed)

Ben-Arye E, Dahly H, Keshet Y, Dagash J, Samuels N. Providing integrative care in the pre-chemotherapy setting: a pragmatic controlled patient-centered trial with implications for supportive cancer care. J Cancer Res Clin Oncol. 2018 Sep;144(9):1825-1833. doi: 10.1007/s00432-018-2700-y. Epub 2018 Jul 6.

Reference Type BACKGROUND
PMID: 29980837 (View on PubMed)

Other Identifiers

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INTEGR.ONCOL.REGIST-2021

Identifier Type: -

Identifier Source: org_study_id