Effect of the Genotype on Postoperative DVT

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

502505 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-06-01

Study Completion Date

2021-06-01

Brief Summary

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Postoperative Venous Thromboembolism Events (VTE) constitute a major source of morbidity and mortality after surgery. The aim of this study was to investigate whether commonly occurring Single Nucleotide Polymorphisms (SNPs) are associated with VTE in the surgical setting.

Detailed Description

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Data extracted from the participants in the UK Biobank collaborative study. Two cohorts will be examined:

1. Surgical cohort, consisting of all patients with a registered surgical procedure in the UK biobank repository
2. Validation cohort, consisting of all non-surgical patients in the UK biobank repository.

A GWAS approach will be used to associated commonly occurring single nucleotide polymorphisms (SNPs) with a postoperative venous thromboembolic event (VTE) within 30 days of a surgical procedure in the surgical cohort.

Findings from the surgical GWAS step will be replicated in the Validation cohort in order to assess whether the same SNPs drive both surgical and non-surgical VTE risk.

A final GWAS model will be fielded, correction for confounders including sex, age, smoking, obesity and open/minimal invasive surgery (surgical discovery GWAS only).

Conditions

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Venous Thromboembolism

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

\- All patients included in the UK biobank repository

Exclusion Criteria

\- None

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Martin Sillesen

Assoc. Prof.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Rigshospitalet

Copenhagen, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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60861

Identifier Type: -

Identifier Source: org_study_id