Intervention for Sleep and Pain in Youth: a Randomized Controlled Trial

NCT ID: NCT04936321

Last Updated: 2024-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

224 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-10-01

Study Completion Date

2025-03-31

Brief Summary

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Insomnia is a common comorbidity among adolescents with migraine. This randomized controlled clinical trial aims to determine efficacy of cognitive-behavioral therapy (CBT) for insomnia, as well as the combined effect of CBT insomnia and pain interventions, on reducing insomnia symptoms and headache-related disability in adolescents with migraine. The long-term goal is to offer effective, tailored self-management interventions that can address migraine and co-morbid sleep problems in adolescence and disrupt a cycle of persistent, disabling migraine from continuing into adulthood.

Detailed Description

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This aims of this study are to: 1) test efficacy of cognitive-behavioral therapy (CBT) insomnia intervention for youth with migraine and comorbid insomnia, and 2) investigate how changes in sleep may modify response to CBT pain intervention. Participants will include 250 youth and their parents. Youth will be ages 11-17 years, with migraine (with or without aura, chronic migraine) and comorbid insomnia. In Phase 1, participants will be randomly assigned to receive access to internet-delivered CBT insomnia intervention or internet-delivered sleep education control over 6 weeks. In Phase 2, all participants will receive access to internet-delivered CBT pain intervention over 6 weeks. Assessments will occur at baseline, immediately after Phase 1 intervention, immediately after Phase 2 intervention, and 6 month follow-up.

Conditions

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Insomnia Migraine Disorders Headache Disorders

Keywords

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pediatric children adolescent sleep pain headache cognitive-behavioral therapy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The study design is a two arm, two-phase RCT. In Phase 1, the effects of internet-delivered CBT insomnia intervention will be compared to internet-delivered sleep education control. In Phase 2, all participants will receive internet-delivered CBT pain intervention.
Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
Because all study procedures delivered online, neither study participants nor investigators. care providers, or outcomes assessors will have knowledge of the treatment assignment and thus this trial can be carried out as a double-blinded RCT.

Study Groups

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Sleep Education + CBT for Pain

Participants will receive access to internet-delivered sleep education during Phase 1 (6 weeks) of the study followed by internet-delivered CBT for pain management during Phase 2 (6 weeks) of the study.

Group Type ACTIVE_COMPARATOR

Internet-delivered CBT for Pain Management

Intervention Type BEHAVIORAL

The program delivers the core components of CBT for pain management including: pain education, training in behavioral and cognitive pain coping skills, instruction in increasing activity participation, and training in parental operant and communication strategies. Treatment duration is 6 weeks.

Internet-delivered Sleep Education

Intervention Type BEHAVIORAL

The program delivers publicly available information about sleep.

CBT for Insomnia + CBT for Pain

Participants will receive access to internet-delivered CBT for insomnia during Phase 1 (6 weeks) of the study followed by internet-delivered CBT for pain management during Phase 2 (6 weeks) of the study.

Group Type EXPERIMENTAL

Internet-delivered CBT for Insomnia

Intervention Type BEHAVIORAL

The program delivers the core components of CBT for insomnia including sleep hygiene, stimulus control, and sleep restriction. Treatment duration is 6 weeks.

Internet-delivered CBT for Pain Management

Intervention Type BEHAVIORAL

The program delivers the core components of CBT for pain management including: pain education, training in behavioral and cognitive pain coping skills, instruction in increasing activity participation, and training in parental operant and communication strategies. Treatment duration is 6 weeks.

Interventions

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Internet-delivered CBT for Insomnia

The program delivers the core components of CBT for insomnia including sleep hygiene, stimulus control, and sleep restriction. Treatment duration is 6 weeks.

Intervention Type BEHAVIORAL

Internet-delivered CBT for Pain Management

The program delivers the core components of CBT for pain management including: pain education, training in behavioral and cognitive pain coping skills, instruction in increasing activity participation, and training in parental operant and communication strategies. Treatment duration is 6 weeks.

Intervention Type BEHAVIORAL

Internet-delivered Sleep Education

The program delivers publicly available information about sleep.

Intervention Type BEHAVIORAL

Other Intervention Names

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Web-MAP (Web-based Management of Adolescent Pain)

Eligibility Criteria

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Inclusion Criteria

* 11-17 years old
* Headache present for at least three months and insomnia symptoms for the past month
* Access to the Internet on any web-enabled device

Exclusion Criteria

* Non-English speaking
* Diagnosed sleep disorder (e.g. sleep apnea, narcolepsy)
* Unable to read at 5th grade level or complete surveys independently
* A serious comorbid chronic condition (e.g., diabetes, arthritis, cancer)
Minimum Eligible Age

11 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Virginia

OTHER

Sponsor Role collaborator

Seattle Children's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Emily Law

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Emily Law, PhD

Role: PRINCIPAL_INVESTIGATOR

Seattle Children's Hospital

Locations

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Seattle Children's Hospital

Seattle, Washington, United States

Site Status

Countries

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United States

References

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Law EF, Ritterband L, Zhou C, Palermo TM. Intervention for Sleep and Pain in Youth (ISPY-RCT): protocol for a two-phase randomized controlled trial of sequenced cognitive-behavioral therapy for insomnia and pain management in adolescents with migraine. Trials. 2023 Jan 12;24(1):25. doi: 10.1186/s13063-022-07035-9.

Reference Type DERIVED
PMID: 36635741 (View on PubMed)

Other Identifiers

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STUDY00003090

Identifier Type: -

Identifier Source: org_study_id