Trial Outcomes & Findings for Adaptive Goals and Interventions for Lifestyle Enhancement (NCT NCT04922216)

Last Updated: 2025-07-20

Results Overview

Estimated mean weight change in kg from baseline to 6 months for each of the two levels of each component (factor) obtained from intent-to-treat (ITT) linear mixed models of analysis of variance. More negative values of weight change indicate greater weight loss (6-month weight - baseline weight).

Recruitment status

COMPLETED

Study phase

Target enrollment

759 participants

Primary outcome timeframe

Baseline, 6 months

Results posted on

2025-07-20

Participant Flow

Recruitment occurred from Apr 2022 to Dec 2023; remote recruitment across the continental United States. 2510 individuals completed the online screening survey; 841 were initially eligible; out of those, 135 completed informed consent but were ineligible due to no longer being interested in participating or incomplete baseline measurement procedures, and 624 completed informed consent and all baseline assessment procedures and were randomized and enrolled in the study.

Individuals who signed informed consent and then completed all baseline measurement procedures (online surveys and remote weight measurements) and remained eligible were considered enrolled and were randomized to 1 of 32 conditions.

Participant milestones

Participant milestones
Measure	1: Standard Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Standard Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	2: Standard Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	3: Standard Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	4: Standard Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	5: Standard Diet Monitoring,Daily Adaptive Activity Goal, Adaptive Timing,Standard Rules,No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	6: Standard Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	7:Standard Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	8: Standard Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	9: Standard Diet Monitoring, Weekly Activity Goal, Fixed Timing, Standard Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	10: Standard Diet Monitoring, Weekly Activity Goal, Fixed Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	11: Standard Diet Monitoring, Weekly Activity Goal, Fixed Timing, Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	12: Standard Diet Monitoring, Weekly Activity Goal, Fixed Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	13:Standard Diet Monitoring,Weekly Adaptive Activity Goal, Adaptive Timing, Standard Rules,No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	14:Standard Diet Monitoring, Weekly Adaptive Activity Goal, Adaptive Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	15:Standard Diet Monitoring,Weekly Adaptive Activity Goal,Adaptive Timing, Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	16: Standard Diet Monitoring, Weekly Adaptive Activity Goal, Adaptive Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	17:Simplified Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Standard Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	18: Simplified Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	19:Simplified Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	20: Simplified Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	21:Simplified Diet Monitoring,Daily Adaptive Activity Goal,Adaptive Timing,Standard Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	22:Simplified Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	23:Simplified Diet Monitoring,Daily Adaptive Activity Goal,Adaptive Timing,Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	24:Simplified Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	25:Simplified Diet Monitoring,Weekly Adaptive Activity Goal, Fixed Timing, Standard Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	26: Simplified Diet Monitoring, Weekly Adaptive Activity Goal, Fixed Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	27:Simplified Diet Monitoring,Weekly Adaptive Activity Goal, Fixed Timing, Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	28: Simplified Diet Monitoring, Weekly Adaptive Activity Goal, Fixed Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	29:Simplified Diet Monitoring,Weekly Adaptive Activity Goal,Adaptive Timing,Standard Rules,No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	30:Simplified Diet Monitoring,Weekly Adaptive Activity Goal, Adaptive Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	31:Simplified Diet Monitoring,Weekly Adaptive Activity Goal,Adaptive Timing,Adaptive Rules,No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	32:Simplified Diet Monitoring, Weekly Adaptive Activity Goal, Adaptive Timing, Adaptive Rules,Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Overall Study STARTED	18	21	20	18	20	18	19	20	20	20	20	19	18	19	20	19	20	20	20	19	20	19	20	19	19	20	20	20	20	20	20	19
Overall Study Completed 3-Month Visit	17	20	20	18	20	18	19	20	20	20	20	19	18	19	20	19	20	19	19	19	19	19	20	19	19	20	19	20	20	20	19	19
Overall Study COMPLETED	17	20	18	18	20	16	19	17	19	18	18	18	16	18	18	19	20	17	18	18	18	19	18	16	19	18	19	20	19	20	17	18
Overall Study NOT COMPLETED	1	1	2	0	0	2	0	3	1	2	2	1	2	1	2	0	0	3	2	1	2	0	2	3	0	2	1	0	1	0	3	1

Reasons for withdrawal

Reasons for withdrawal
Measure	1: Standard Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Standard Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	2: Standard Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	3: Standard Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	4: Standard Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	5: Standard Diet Monitoring,Daily Adaptive Activity Goal, Adaptive Timing,Standard Rules,No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	6: Standard Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	7:Standard Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	8: Standard Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	9: Standard Diet Monitoring, Weekly Activity Goal, Fixed Timing, Standard Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	10: Standard Diet Monitoring, Weekly Activity Goal, Fixed Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	11: Standard Diet Monitoring, Weekly Activity Goal, Fixed Timing, Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	12: Standard Diet Monitoring, Weekly Activity Goal, Fixed Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	13:Standard Diet Monitoring,Weekly Adaptive Activity Goal, Adaptive Timing, Standard Rules,No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	14:Standard Diet Monitoring, Weekly Adaptive Activity Goal, Adaptive Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	15:Standard Diet Monitoring,Weekly Adaptive Activity Goal,Adaptive Timing, Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	16: Standard Diet Monitoring, Weekly Adaptive Activity Goal, Adaptive Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	17:Simplified Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Standard Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	18: Simplified Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	19:Simplified Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	20: Simplified Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	21:Simplified Diet Monitoring,Daily Adaptive Activity Goal,Adaptive Timing,Standard Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	22:Simplified Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	23:Simplified Diet Monitoring,Daily Adaptive Activity Goal,Adaptive Timing,Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	24:Simplified Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	25:Simplified Diet Monitoring,Weekly Adaptive Activity Goal, Fixed Timing, Standard Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	26: Simplified Diet Monitoring, Weekly Adaptive Activity Goal, Fixed Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	27:Simplified Diet Monitoring,Weekly Adaptive Activity Goal, Fixed Timing, Adaptive Rules, No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	28: Simplified Diet Monitoring, Weekly Adaptive Activity Goal, Fixed Timing, Adaptive Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	29:Simplified Diet Monitoring,Weekly Adaptive Activity Goal,Adaptive Timing,Standard Rules,No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	30:Simplified Diet Monitoring,Weekly Adaptive Activity Goal, Adaptive Timing, Standard Rules, Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	31:Simplified Diet Monitoring,Weekly Adaptive Activity Goal,Adaptive Timing,Adaptive Rules,No Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	32:Simplified Diet Monitoring, Weekly Adaptive Activity Goal, Adaptive Timing, Adaptive Rules,Choice Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Overall Study Withdrawal by Subject	0	1	0	0	0	0	0	2	0	0	0	0	1	1	1	0	0	1	1	1	1	0	0	2	0	0	1	0	0	0	1	0
Overall Study Lost to Follow-up	1	0	2	0	0	2	0	1	1	2	2	1	1	0	1	0	0	2	1	0	1	0	2	1	0	2	0	0	1	0	2	1

Baseline Characteristics

Adaptive Goals and Interventions for Lifestyle Enhancement

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	1: Standard Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Standard Rules, No Choice n=18 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	2: Standard Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Standard Rules, Choice n=21 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	3: Standard Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Adaptive Rules, No Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	4: Standard Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Adaptive Rules, Choice n=18 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	5: Standard Diet Monitoring,Daily Adaptive Activity Goal, Adaptive Timing,Standard Rules,No Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	6: Standard Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Standard Rules, Choice n=18 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	7:Standard Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Adaptive Rules, No Choice n=19 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	8: Standard Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Adaptive Rules, Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	9: Standard Diet Monitoring, Weekly Activity Goal, Fixed Timing, Standard Rules, No Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	10: Standard Diet Monitoring, Weekly Activity Goal, Fixed Timing, Standard Rules, Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	11: Standard Diet Monitoring, Weekly Activity Goal, Fixed Timing, Adaptive Rules, No Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	12: Standard Diet Monitoring, Weekly Activity Goal, Fixed Timing, Adaptive Rules, Choice n=19 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	13:Standard Diet Monitoring,Weekly Adaptive Activity Goal, Adaptive Timing, Standard Rules,No Choice n=18 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	14:Standard Diet Monitoring, Weekly Adaptive Activity Goal, Adaptive Timing, Standard Rules, Choice n=19 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	15:Standard Diet Monitoring,Weekly Adaptive Activity Goal,Adaptive Timing, Adaptive Rules, No Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	16: Standard Diet Monitoring, Weekly Adaptive Activity Goal, Adaptive Timing, Adaptive Rules, Choice n=19 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Standard Diet Monitoring Standard monitoring using smartphone tracking of all calorie intake. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	17:Simplified Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Standard Rules, No Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	18: Simplified Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Standard Rules, Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	19:Simplified Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Adaptive Rules, No Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	20: Simplified Diet Monitoring, Daily Adaptive Activity Goal, Fixed Timing, Adaptive Rules, Choice n=19 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	21:Simplified Diet Monitoring,Daily Adaptive Activity Goal,Adaptive Timing,Standard Rules, No Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	22:Simplified Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Standard Rules, Choice n=19 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	23:Simplified Diet Monitoring,Daily Adaptive Activity Goal,Adaptive Timing,Adaptive Rules, No Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	24:Simplified Diet Monitoring, Daily Adaptive Activity Goal, Adaptive Timing, Adaptive Rules, Choice n=19 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Daily) Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	25:Simplified Diet Monitoring,Weekly Adaptive Activity Goal, Fixed Timing, Standard Rules, No Choice n=19 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	26: Simplified Diet Monitoring, Weekly Adaptive Activity Goal, Fixed Timing, Standard Rules, Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	27:Simplified Diet Monitoring,Weekly Adaptive Activity Goal, Fixed Timing, Adaptive Rules, No Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	28: Simplified Diet Monitoring, Weekly Adaptive Activity Goal, Fixed Timing, Adaptive Rules, Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Fixed) Message timing is fixed and evaluated at specific times each day to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	29:Simplified Diet Monitoring,Weekly Adaptive Activity Goal,Adaptive Timing,Standard Rules,No Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	30:Simplified Diet Monitoring,Weekly Adaptive Activity Goal, Adaptive Timing, Standard Rules, Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Standard) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	31:Simplified Diet Monitoring,Weekly Adaptive Activity Goal,Adaptive Timing,Adaptive Rules,No Choice n=20 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (No) Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	32:Simplified Diet Monitoring, Weekly Adaptive Activity Goal, Adaptive Timing, Adaptive Rules,Choice n=19 Participants Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Behavioral: Simplified Diet Monitoring Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Behavioral: Adaptive Activity Goals (Weekly) Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Behavioral: Message Decision Points (Adaptive) Message timing is adaptive and derived from individual user data to determine message eligibility. Behavioral: Message Decision Rules (Adaptive) Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Behavioral: Message Choice (Yes) Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Total n=624 Participants Total of all reporting groups
Age, Continuous	30.4 years STANDARD_DEVIATION 5.6 • n=5 Participants	30.9 years STANDARD_DEVIATION 5.4 • n=7 Participants	33.2 years STANDARD_DEVIATION 4.4 • n=5 Participants	31.4 years STANDARD_DEVIATION 5.0 • n=4 Participants	31.3 years STANDARD_DEVIATION 4.6 • n=21 Participants	32.1 years STANDARD_DEVIATION 4.5 • n=8 Participants	29.0 years STANDARD_DEVIATION 4.7 • n=8 Participants	29.9 years STANDARD_DEVIATION 5.7 • n=24 Participants	30.1 years STANDARD_DEVIATION 4.7 • n=42 Participants	33.5 years STANDARD_DEVIATION 4.0 • n=42 Participants	30.6 years STANDARD_DEVIATION 4.7 • n=42 Participants	32.4 years STANDARD_DEVIATION 4.9 • n=42 Participants	30.3 years STANDARD_DEVIATION 3.2 • n=36 Participants	32.4 years STANDARD_DEVIATION 4.5 • n=36 Participants	32.8 years STANDARD_DEVIATION 3.9 • n=24 Participants	31.2 years STANDARD_DEVIATION 5.7 • n=135 Participants	30.9 years STANDARD_DEVIATION 4.5 • n=136 Participants	30.0 years STANDARD_DEVIATION 5.3 • n=44 Participants	29.5 years STANDARD_DEVIATION 5.3 • n=667 Participants	30.5 years STANDARD_DEVIATION 4.9 • n=15 Participants	31.4 years STANDARD_DEVIATION 4.3 • n=40 Participants	30.9 years STANDARD_DEVIATION 4.8 • n=40 Participants	30.5 years STANDARD_DEVIATION 6.0 • n=41 Participants	27.1 years STANDARD_DEVIATION 5.4 • n=600 Participants	33.0 years STANDARD_DEVIATION 3.9 • n=4 Participants	30.7 years STANDARD_DEVIATION 6.2 • n=4 Participants	32.9 years STANDARD_DEVIATION 3.8 • n=26 Participants	31.2 years STANDARD_DEVIATION 4.7 • n=12 Participants	31.2 years STANDARD_DEVIATION 5.0 • n=206 Participants	32.6 years STANDARD_DEVIATION 4.5 • n=12 Participants	29.7 years STANDARD_DEVIATION 4.9 • n=12 Participants	33.6 years STANDARD_DEVIATION 4.1 • n=12 Participants	31.2 years STANDARD_DEVIATION 4.9 • n=384 Participants
Sex/Gender, Customized Female	13 Participants n=5 Participants	14 Participants n=7 Participants	11 Participants n=5 Participants	12 Participants n=4 Participants	10 Participants n=21 Participants	9 Participants n=8 Participants	14 Participants n=8 Participants	14 Participants n=24 Participants	14 Participants n=42 Participants	16 Participants n=42 Participants	16 Participants n=42 Participants	11 Participants n=42 Participants	12 Participants n=36 Participants	9 Participants n=36 Participants	13 Participants n=24 Participants	11 Participants n=135 Participants	14 Participants n=136 Participants	15 Participants n=44 Participants	14 Participants n=667 Participants	16 Participants n=15 Participants	14 Participants n=40 Participants	14 Participants n=40 Participants	10 Participants n=41 Participants	14 Participants n=600 Participants	14 Participants n=4 Participants	14 Participants n=4 Participants	16 Participants n=26 Participants	13 Participants n=12 Participants	12 Participants n=206 Participants	12 Participants n=12 Participants	13 Participants n=12 Participants	14 Participants n=12 Participants	418 Participants n=384 Participants
Sex/Gender, Customized Male	4 Participants n=5 Participants	7 Participants n=7 Participants	9 Participants n=5 Participants	6 Participants n=4 Participants	9 Participants n=21 Participants	8 Participants n=8 Participants	5 Participants n=8 Participants	6 Participants n=24 Participants	6 Participants n=42 Participants	4 Participants n=42 Participants	4 Participants n=42 Participants	8 Participants n=42 Participants	6 Participants n=36 Participants	10 Participants n=36 Participants	7 Participants n=24 Participants	8 Participants n=135 Participants	6 Participants n=136 Participants	5 Participants n=44 Participants	6 Participants n=667 Participants	3 Participants n=15 Participants	6 Participants n=40 Participants	5 Participants n=40 Participants	10 Participants n=41 Participants	5 Participants n=600 Participants	5 Participants n=4 Participants	6 Participants n=4 Participants	4 Participants n=26 Participants	7 Participants n=12 Participants	8 Participants n=206 Participants	8 Participants n=12 Participants	7 Participants n=12 Participants	5 Participants n=12 Participants	203 Participants n=384 Participants
Sex/Gender, Customized Don't know	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants	0 Participants n=21 Participants	1 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	0 Participants n=36 Participants	0 Participants n=24 Participants	0 Participants n=135 Participants	0 Participants n=136 Participants	0 Participants n=44 Participants	0 Participants n=667 Participants	0 Participants n=15 Participants	0 Participants n=40 Participants	0 Participants n=40 Participants	0 Participants n=41 Participants	0 Participants n=600 Participants	0 Participants n=4 Participants	0 Participants n=4 Participants	0 Participants n=26 Participants	0 Participants n=12 Participants	0 Participants n=206 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	1 Participants n=384 Participants
Sex/Gender, Customized Prefer not to answer	1 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants	1 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	0 Participants n=36 Participants	0 Participants n=24 Participants	0 Participants n=135 Participants	0 Participants n=136 Participants	0 Participants n=44 Participants	0 Participants n=667 Participants	0 Participants n=15 Participants	0 Participants n=40 Participants	0 Participants n=40 Participants	0 Participants n=41 Participants	0 Participants n=600 Participants	0 Participants n=4 Participants	0 Participants n=4 Participants	0 Participants n=26 Participants	0 Participants n=12 Participants	0 Participants n=206 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	2 Participants n=384 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	2 Participants n=5 Participants	3 Participants n=7 Participants	3 Participants n=5 Participants	3 Participants n=4 Participants	2 Participants n=21 Participants	1 Participants n=8 Participants	1 Participants n=8 Participants	3 Participants n=24 Participants	6 Participants n=42 Participants	3 Participants n=42 Participants	1 Participants n=42 Participants	3 Participants n=42 Participants	4 Participants n=36 Participants	1 Participants n=36 Participants	3 Participants n=24 Participants	1 Participants n=135 Participants	1 Participants n=136 Participants	3 Participants n=44 Participants	3 Participants n=667 Participants	1 Participants n=15 Participants	0 Participants n=40 Participants	5 Participants n=40 Participants	3 Participants n=41 Participants	2 Participants n=600 Participants	2 Participants n=4 Participants	2 Participants n=4 Participants	4 Participants n=26 Participants	1 Participants n=12 Participants	5 Participants n=206 Participants	4 Participants n=12 Participants	1 Participants n=12 Participants	2 Participants n=12 Participants	79 Participants n=384 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	15 Participants n=5 Participants	18 Participants n=7 Participants	16 Participants n=5 Participants	15 Participants n=4 Participants	17 Participants n=21 Participants	17 Participants n=8 Participants	18 Participants n=8 Participants	17 Participants n=24 Participants	14 Participants n=42 Participants	16 Participants n=42 Participants	19 Participants n=42 Participants	16 Participants n=42 Participants	14 Participants n=36 Participants	18 Participants n=36 Participants	17 Participants n=24 Participants	18 Participants n=135 Participants	19 Participants n=136 Participants	17 Participants n=44 Participants	17 Participants n=667 Participants	16 Participants n=15 Participants	20 Participants n=40 Participants	13 Participants n=40 Participants	17 Participants n=41 Participants	17 Participants n=600 Participants	17 Participants n=4 Participants	18 Participants n=4 Participants	16 Participants n=26 Participants	19 Participants n=12 Participants	15 Participants n=206 Participants	16 Participants n=12 Participants	18 Participants n=12 Participants	17 Participants n=12 Participants	537 Participants n=384 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	1 Participants n=5 Participants	0 Participants n=7 Participants	1 Participants n=5 Participants	0 Participants n=4 Participants	1 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	1 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	0 Participants n=36 Participants	0 Participants n=24 Participants	0 Participants n=135 Participants	0 Participants n=136 Participants	0 Participants n=44 Participants	0 Participants n=667 Participants	2 Participants n=15 Participants	0 Participants n=40 Participants	1 Participants n=40 Participants	0 Participants n=41 Participants	0 Participants n=600 Participants	0 Participants n=4 Participants	0 Participants n=4 Participants	0 Participants n=26 Participants	0 Participants n=12 Participants	0 Participants n=206 Participants	0 Participants n=12 Participants	1 Participants n=12 Participants	0 Participants n=12 Participants	8 Participants n=384 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	1 Participants n=4 Participants	0 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	0 Participants n=36 Participants	0 Participants n=24 Participants	0 Participants n=135 Participants	0 Participants n=136 Participants	1 Participants n=44 Participants	0 Participants n=667 Participants	0 Participants n=15 Participants	0 Participants n=40 Participants	0 Participants n=40 Participants	0 Participants n=41 Participants	0 Participants n=600 Participants	1 Participants n=4 Participants	0 Participants n=4 Participants	0 Participants n=26 Participants	0 Participants n=12 Participants	0 Participants n=206 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	1 Participants n=12 Participants	4 Participants n=384 Participants
Race (NIH/OMB) Asian	4 Participants n=5 Participants	1 Participants n=7 Participants	2 Participants n=5 Participants	0 Participants n=4 Participants	2 Participants n=21 Participants	5 Participants n=8 Participants	2 Participants n=8 Participants	1 Participants n=24 Participants	2 Participants n=42 Participants	1 Participants n=42 Participants	4 Participants n=42 Participants	2 Participants n=42 Participants	2 Participants n=36 Participants	4 Participants n=36 Participants	0 Participants n=24 Participants	5 Participants n=135 Participants	4 Participants n=136 Participants	4 Participants n=44 Participants	1 Participants n=667 Participants	2 Participants n=15 Participants	2 Participants n=40 Participants	1 Participants n=40 Participants	6 Participants n=41 Participants	1 Participants n=600 Participants	0 Participants n=4 Participants	3 Participants n=4 Participants	1 Participants n=26 Participants	3 Participants n=12 Participants	2 Participants n=206 Participants	3 Participants n=12 Participants	3 Participants n=12 Participants	0 Participants n=12 Participants	73 Participants n=384 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants	0 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	0 Participants n=36 Participants	0 Participants n=24 Participants	0 Participants n=135 Participants	0 Participants n=136 Participants	0 Participants n=44 Participants	0 Participants n=667 Participants	0 Participants n=15 Participants	0 Participants n=40 Participants	0 Participants n=40 Participants	0 Participants n=41 Participants	0 Participants n=600 Participants	0 Participants n=4 Participants	0 Participants n=4 Participants	0 Participants n=26 Participants	0 Participants n=12 Participants	0 Participants n=206 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	0 Participants n=384 Participants
Race (NIH/OMB) Black or African American	2 Participants n=5 Participants	7 Participants n=7 Participants	2 Participants n=5 Participants	3 Participants n=4 Participants	4 Participants n=21 Participants	2 Participants n=8 Participants	2 Participants n=8 Participants	4 Participants n=24 Participants	3 Participants n=42 Participants	4 Participants n=42 Participants	6 Participants n=42 Participants	1 Participants n=42 Participants	2 Participants n=36 Participants	5 Participants n=36 Participants	3 Participants n=24 Participants	5 Participants n=135 Participants	4 Participants n=136 Participants	6 Participants n=44 Participants	3 Participants n=667 Participants	5 Participants n=15 Participants	4 Participants n=40 Participants	4 Participants n=40 Participants	3 Participants n=41 Participants	3 Participants n=600 Participants	6 Participants n=4 Participants	2 Participants n=4 Participants	7 Participants n=26 Participants	2 Participants n=12 Participants	4 Participants n=206 Participants	1 Participants n=12 Participants	5 Participants n=12 Participants	8 Participants n=12 Participants	122 Participants n=384 Participants
Race (NIH/OMB) White	8 Participants n=5 Participants	11 Participants n=7 Participants	12 Participants n=5 Participants	13 Participants n=4 Participants	13 Participants n=21 Participants	9 Participants n=8 Participants	14 Participants n=8 Participants	15 Participants n=24 Participants	14 Participants n=42 Participants	11 Participants n=42 Participants	8 Participants n=42 Participants	15 Participants n=42 Participants	11 Participants n=36 Participants	10 Participants n=36 Participants	15 Participants n=24 Participants	9 Participants n=135 Participants	10 Participants n=136 Participants	8 Participants n=44 Participants	12 Participants n=667 Participants	7 Participants n=15 Participants	13 Participants n=40 Participants	10 Participants n=40 Participants	10 Participants n=41 Participants	13 Participants n=600 Participants	10 Participants n=4 Participants	14 Participants n=4 Participants	8 Participants n=26 Participants	14 Participants n=12 Participants	12 Participants n=206 Participants	13 Participants n=12 Participants	10 Participants n=12 Participants	9 Participants n=12 Participants	361 Participants n=384 Participants
Race (NIH/OMB) More than one race	2 Participants n=5 Participants	2 Participants n=7 Participants	2 Participants n=5 Participants	1 Participants n=4 Participants	0 Participants n=21 Participants	2 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	1 Participants n=42 Participants	2 Participants n=42 Participants	1 Participants n=42 Participants	1 Participants n=42 Participants	3 Participants n=36 Participants	0 Participants n=36 Participants	2 Participants n=24 Participants	0 Participants n=135 Participants	1 Participants n=136 Participants	1 Participants n=44 Participants	2 Participants n=667 Participants	3 Participants n=15 Participants	1 Participants n=40 Participants	2 Participants n=40 Participants	1 Participants n=41 Participants	1 Participants n=600 Participants	0 Participants n=4 Participants	1 Participants n=4 Participants	4 Participants n=26 Participants	0 Participants n=12 Participants	1 Participants n=206 Participants	2 Participants n=12 Participants	0 Participants n=12 Participants	1 Participants n=12 Participants	40 Participants n=384 Participants
Race (NIH/OMB) Unknown or Not Reported	2 Participants n=5 Participants	0 Participants n=7 Participants	2 Participants n=5 Participants	0 Participants n=4 Participants	1 Participants n=21 Participants	0 Participants n=8 Participants	1 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	2 Participants n=42 Participants	1 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	0 Participants n=36 Participants	0 Participants n=24 Participants	0 Participants n=135 Participants	1 Participants n=136 Participants	0 Participants n=44 Participants	2 Participants n=667 Participants	2 Participants n=15 Participants	0 Participants n=40 Participants	2 Participants n=40 Participants	0 Participants n=41 Participants	1 Participants n=600 Participants	2 Participants n=4 Participants	0 Participants n=4 Participants	0 Participants n=26 Participants	1 Participants n=12 Participants	1 Participants n=206 Participants	1 Participants n=12 Participants	2 Participants n=12 Participants	0 Participants n=12 Participants	24 Participants n=384 Participants
Weight (lb)	207.7 pounds STANDARD_DEVIATION 52.3 • n=5 Participants	208.5 pounds STANDARD_DEVIATION 35.1 • n=7 Participants	206.8 pounds STANDARD_DEVIATION 45.1 • n=5 Participants	214.9 pounds STANDARD_DEVIATION 38.7 • n=4 Participants	210.5 pounds STANDARD_DEVIATION 41.5 • n=21 Participants	212.1 pounds STANDARD_DEVIATION 36.3 • n=8 Participants	195.7 pounds STANDARD_DEVIATION 36.5 • n=8 Participants	200.3 pounds STANDARD_DEVIATION 43.3 • n=24 Participants	203.1 pounds STANDARD_DEVIATION 33.4 • n=42 Participants	208.8 pounds STANDARD_DEVIATION 33.2 • n=42 Participants	195.2 pounds STANDARD_DEVIATION 32.4 • n=42 Participants	224.4 pounds STANDARD_DEVIATION 36.2 • n=42 Participants	190.8 pounds STANDARD_DEVIATION 28.5 • n=36 Participants	233.9 pounds STANDARD_DEVIATION 45.6 • n=36 Participants	218.2 pounds STANDARD_DEVIATION 39.8 • n=24 Participants	185.7 pounds STANDARD_DEVIATION 34.3 • n=135 Participants	200.7 pounds STANDARD_DEVIATION 49.7 • n=136 Participants	195.0 pounds STANDARD_DEVIATION 47.7 • n=44 Participants	219.5 pounds STANDARD_DEVIATION 53.4 • n=667 Participants	201.5 pounds STANDARD_DEVIATION 41.8 • n=15 Participants	206.1 pounds STANDARD_DEVIATION 36.3 • n=40 Participants	211.0 pounds STANDARD_DEVIATION 39.6 • n=40 Participants	207.5 pounds STANDARD_DEVIATION 45.6 • n=41 Participants	216.3 pounds STANDARD_DEVIATION 45.1 • n=600 Participants	210.6 pounds STANDARD_DEVIATION 33.6 • n=4 Participants	203.8 pounds STANDARD_DEVIATION 40.4 • n=4 Participants	203.0 pounds STANDARD_DEVIATION 37.1 • n=26 Participants	200.9 pounds STANDARD_DEVIATION 33.9 • n=12 Participants	218.3 pounds STANDARD_DEVIATION 42.0 • n=206 Participants	198.5 pounds STANDARD_DEVIATION 22.3 • n=12 Participants	206.0 pounds STANDARD_DEVIATION 49.8 • n=12 Participants	215.8 pounds STANDARD_DEVIATION 33.5 • n=12 Participants	207.2 pounds STANDARD_DEVIATION 40.3 • n=384 Participants

PRIMARY outcome

Timeframe: Baseline, 6 months

Population: ITT: all randomized participants using all available weights.

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=309 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=315 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=313 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=311 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=314 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=310 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=314 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=310 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Weight (kg)	-3.61 kg Interval -4.25 to -2.97	-3.31 kg Interval -3.95 to -2.68	-3.32 kg Interval -3.96 to -2.68	-3.60 kg Interval -4.24 to -2.96	-3.66 kg Interval -4.29 to -3.02	-3.26 kg Interval -3.9 to -2.61	-3.65 kg Interval -4.29 to -3.02	-3.26 kg Interval -3.91 to -2.62	-3.19 kg Interval -3.83 to -2.55	-3.73 kg Interval -4.38 to -3.09

SECONDARY outcome

Timeframe: Baseline, 3 months

Estimated mean weight change in kg from baseline to 3 months for each of the two levels of each component (factor) obtained from intent-to-treat (ITT) linear mixed models of analysis of variance. More negative values of weight change indicate greater weight loss (3-month weight - baseline weight).

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=309 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=315 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=313 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=311 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=314 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=310 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=314 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=310 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Weight (kg)	-2.54 kg Interval -2.97 to -2.12	-2.30 kg Interval -2.72 to -1.88	-2.22 kg Interval -2.64 to -1.8	-2.63 kg Interval -3.06 to -2.21	-2.69 kg Interval -3.11 to -2.27	-2.16 kg Interval -2.58 to -1.74	-2.58 kg Interval -3.0 to -2.16	-2.26 kg Interval -2.69 to -1.84	-2.27 kg Interval -2.69 to -1.84	-2.58 kg Interval -3.0 to -2.16

SECONDARY outcome

Timeframe: Baseline to 6 months

Population: Participants with a 6-month weight value (total N = 583).

Percent change in body weight will be calculated (6 month weight - baseline weight/100) and determined to be at or above 5% indicating a clinically significant change.

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=289 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=294 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=294 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=289 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=295 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=288 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=294 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=289 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=293 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=290 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Percent of Participants Reaching >/= 5% Weight Loss	100 Participants	101 Participants	89 Participants	112 Participants	107 Participants	94 Participants	101 Participants	100 Participants	95 Participants	106 Participants

SECONDARY outcome

Timeframe: Baseline, 6 months

Population: Participants who completed at least one 24-hour recall at 6 months (total N = 565).

Change in daily caloric intake from baseline to 6 months as measured using the self-administered National Cancer Institute's Automated Self- Administered 24-hour Recall (ASA-24), a 24-hour recall that is self-administered on a week day and a weekend day at each timepoint. Change calculated as (daily kcal at 6 months - daily kcal at baseline).

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=282 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=283 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=289 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=276 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=283 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=282 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=278 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=287 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=284 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=281 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Diet	-378.6 kcal/day Standard Deviation 765.8	-485.3 kcal/day Standard Deviation 813.4	-470.3 kcal/day Standard Deviation 811.3	-391.9 kcal/day Standard Deviation 768.8	-452.3 kcal/day Standard Deviation 807.2	-411.6 kcal/day Standard Deviation 775.5	-439.7 kcal/day Standard Deviation 775.7	-424.6 kcal/day Standard Deviation 807.1	-476.9 kcal/day Standard Deviation 841.6	-386.7 kcal/day Standard Deviation 735.3

SECONDARY outcome

Timeframe: Baseline,3 months, 6 months

Population: Participants who completed the PPAQ at 3 months; participants who completed the PPAQ at 6 months.

Change in physical activity from baseline to 3 and 6 months as measured using the Paffenbarger Physical Activity Questionnaire (PPAQ). The PPAQ assesses amount of planned and lifestyle associated physical activity performed during a typical week. The PPAQ consists of three components: (1) stair climbing, (2) walking, and (3) sports and recreation. Participants report the frequency and duration of physical activity in the past week. Scoring yields energy expenditure from physical activity per week (kcal/week). Higher scores translate into greater energy expenditure per week (i.e.,better outcome). Range is 0 - no theoretical maximum. Outcome is change in kcal burned per week.

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=309 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=315 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=313 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=311 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=314 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=310 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=314 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=310 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Physical Activity Baseline to 3 Months	180.4 kcal/week Standard Deviation 939.5	322.6 kcal/week Standard Deviation 1089.8	252.1 kcal/week Standard Deviation 967.1	250.8 kcal/week Standard Deviation 1072.5	309.3 kcal/week Standard Deviation 1074.4	192.9 kcal/week Standard Deviation 957.8	268.0 kcal/week Standard Deviation 1075.3	234.8 kcal/week Standard Deviation 960.1	149.8 kcal/week Standard Deviation 934.7	353.2 kcal/week Standard Deviation 1089.0
Physical Activity Baseline to 6 Months	167.1 kcal/week Standard Deviation 927.9	92.1 kcal/week Standard Deviation 861.5	128.0 kcal/week Standard Deviation 899.1	131.0 kcal/week Standard Deviation 892.7	163.6 kcal/week Standard Deviation 911.8	94.4 kcal/week Standard Deviation 878.0	131.7 kcal/week Standard Deviation 899.5	127.3 kcal/week Standard Deviation 892.4	102.9 kcal/week Standard Deviation 854.0	156.6 kcal/week Standard Deviation 936.2

SECONDARY outcome

Timeframe: Baseline, 3 months, 6 months

Population: Participants who completed the Sedentary Behavior Questionnaire at 3 months; participants who completed the Sedentary Behavior Questionnaire at 6 months.

Change in sedentary behavior from baseline to 3 and 6 months as measured using the 12- item Sedentary Behavior Questionnaire which asks respondents to indicate the number of hours they spend on a typical weekday and a typical weekend day doing each of six activities. The scale ranges from "none" to "6 or more hours" for each item. Higher values on the Sedentary Behavior Questionnaire indicate greater amount of time spent in sedentary behavior. Range is 0 to 24 hours and outcome is change in minutes per day.

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=309 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=315 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=313 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=311 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=314 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=310 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=314 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=310 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Sedentary Behavior Score Baseline to 3 Months	-35.3 minutes/day Standard Deviation 207.6	-36.1 minutes/day Standard Deviation 223.4	-33.9 minutes/day Standard Deviation 194.0	-37.6 minutes/day Standard Deviation 236.2	-41.1 minutes/day Standard Deviation 200.9	-30.3 minutes/day Standard Deviation 229.5	-40.9 minutes/day Standard Deviation 217.3	-30.5 minutes/day Standard Deviation 213.9	-34.1 minutes/day Standard Deviation 222.9	-37.4 minutes/day Standard Deviation 208.1
Sedentary Behavior Score Baseline to 6 Months	-22.7 minutes/day Standard Deviation 218.9	-34.1 minutes/day Standard Deviation 227.0	-11.8 minutes/day Standard Deviation 223.7	-45.7 minutes/day Standard Deviation 221.1	-39.9 minutes/day Standard Deviation 223.7	-16.6 minutes/day Standard Deviation 221.8	-28.3 minutes/day Standard Deviation 230.1	-28.6 minutes/day Standard Deviation 215.9	-28.3 minutes/day Standard Deviation 236.8	-28.5 minutes/day Standard Deviation 208.1

SECONDARY outcome

Timeframe: 3 months, 6 months

Population: Participants who completed the Health Care Climate Questionnaire at 3 months; participants who completed the Health Care Climate Questionnaire at 6 months.

Autonomy support at 3 and 6 months. Items are adapted from the Health Care Climate Questionnaire, which is a measure of how the participant perceives support from a healthcare provider, to measure autonomy support from the program. The scale includes 15 items rated on a scale of 1 (strongly disagree) to 7 (strongly agree) (e.g., "I feel that \[the program\] has provided me choices and options.") Scores are calculated by averaging the individual item scores (with item 13 reverse-scored). Higher average scores represent a higher level of perceived autonomy support. Outcomes are the mean value at 3 months and the mean value at 6 months.

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=309 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=315 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=313 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=311 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=314 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=310 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=314 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=310 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Autonomy Support Score 3 Months	5.14 score on a scale Standard Deviation 1.20	5.11 score on a scale Standard Deviation 1.11	5.08 score on a scale Standard Deviation 1.15	5.17 score on a scale Standard Deviation 1.15	5.16 score on a scale Standard Deviation 1.15	5.09 score on a scale Standard Deviation 1.16	5.12 score on a scale Standard Deviation 1.17	5.13 score on a scale Standard Deviation 1.13	5.13 score on a scale Standard Deviation 1.15	5.12 score on a scale Standard Deviation 1.15
Autonomy Support Score 6 Months	5.13 score on a scale Standard Deviation 1.22	5.08 score on a scale Standard Deviation 1.30	5.05 score on a scale Standard Deviation 1.25	5.12 score on a scale Standard Deviation 1.28	5.08 score on a scale Standard Deviation 1.23	5.11 score on a scale Standard Deviation 1.26	5.12 score on a scale Standard Deviation 1.22	5.09 score on a scale Standard Deviation 1.25	5.07 score on a scale Standard Deviation 1.29	5.15 score on a scale Standard Deviation 1.26

SECONDARY outcome

Timeframe: Baseline, 3 months, 6 months

Population: Participants who completed the Perceived Competence Scale for Diet at 3 months; participants who completed the Perceived Competence Scale for Diet at 6 months.

Change in perceived competence from baseline to 3 and 6 months as measured using the The Perceived Competence Scale. The Scale measures perceived competence for diet (4 items) and physical activity (4 items). Items are rated on a 7-point Likert scale (1 = not at all true, 7 = very true), and include items such as "I feel confident in my ability to maintain a healthy diet." Scores are summed for the items in the subscale (diet and physical activity) and the range for each subscale is 4 - 28. Greater values indicate higher levels of perceived competence for engaging in positive diet and physical activity behaviors. Scores are summed for the items in each subscale separately (diet and physical activity). Outcomes are change in perceived competence for diet and change in perceived competence for physical activity.

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=309 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=315 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=313 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=311 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=314 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=310 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=314 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=310 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Competence for Diet and Physical Activity Scores Competence for Diet - Baseline to 3 Months	0.88 score on a scale Standard Deviation 6.01	0.74 score on a scale Standard Deviation 6.36	0.41 score on a scale Standard Deviation 6.17	1.23 score on a scale Standard Deviation 6.17	0.78 score on a scale Standard Deviation 6.22	0.84 score on a scale Standard Deviation 6.15	1.32 score on a scale Standard Deviation 5.66	0.29 score on a scale Standard Deviation 6.64	0.62 score on a scale Standard Deviation 6.05	1.00 score on a scale Standard Deviation 6.32
Competence for Diet and Physical Activity Scores Competence for Physical Activity - Baseline to 3 Months	-0.83 score on a scale Standard Deviation 6.51	-1.50 score on a scale Standard Deviation 6.09	-1.10 score on a scale Standard Deviation 6.37	-1.23 score on a scale Standard Deviation 6.25	-1.27 score on a scale Standard Deviation 6.36	-1.06 score on a scale Standard Deviation 6.26	-0.92 score on a scale Standard Deviation 6.28	-1.42 score on a scale Standard Deviation 6.33	-1.02 score on a scale Standard Deviation 6.55	-1.31 score on a scale Standard Deviation 6.05
Competence for Diet and Physical Activity Scores Competence for Diet - Baseline to 6 Months	2.03 score on a scale Standard Deviation 6.76	1.62 score on a scale Standard Deviation 6.81	1.74 score on a scale Standard Deviation 6.75	1.90 score on a scale Standard Deviation 6.83	1.91 score on a scale Standard Deviation 6.97	1.74 score on a scale Standard Deviation 6.60	2.26 score on a scale Standard Deviation 6.51	1.38 score on a scale Standard Deviation 7.03	1.81 score on a scale Standard Deviation 6.83	1.83 score on a scale Standard Deviation 6.75
Competence for Diet and Physical Activity Scores Competence for Physical Activity - Baseline to 6 Months	-0.14 score on a scale Standard Deviation 6.67	-1.18 score on a scale Standard Deviation 6.57	-0.87 score on a scale Standard Deviation 6.65	-0.44 score on a scale Standard Deviation 6.62	-0.87 score on a scale Standard Deviation 6.84	-0.45 score on a scale Standard Deviation 6.41	-0.40 score on a scale Standard Deviation 6.40	-0.92 score on a scale Standard Deviation 6.86	-0.31 score on a scale Standard Deviation 7.03	-1.03 score on a scale Standard Deviation 6.20

SECONDARY outcome

Timeframe: 3 months, 6 months

Population: Participants who completed message relevance items at 3 months; participants who completed message relevance items at 6 months.

Perceived message relevance at 3 and 6 months as measured using two items used in our previous work and adapted from previous studies of tailored messages. Participants were asked to rate how strongly they disagree or agree with the statements about messages being "written personally for me" and "applied to my life." Responses are on a 5-point scale from 1 (strongly disagree) to 5 (strongly agree). The values of the two items are averaged for a final score. Higher values indicate that a participant perceives the messages received in the program are more relevant to them.

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=309 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=315 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=313 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=311 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=314 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=310 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=314 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=310 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Perceived Message Relevance Score 6 Months	3.36 score on a scale Standard Deviation 1.01	3.33 score on a scale Standard Deviation 1.05	3.35 score on a scale Standard Deviation 0.99	3.35 score on a scale Standard Deviation 1.07	3.37 score on a scale Standard Deviation 1.01	3.33 score on a scale Standard Deviation 1.05	3.34 score on a scale Standard Deviation 1.04	3.36 score on a scale Standard Deviation 1.02	3.36 score on a scale Standard Deviation 1.05	3.33 score on a scale Standard Deviation 1.01
Perceived Message Relevance Score 3 Months	3.34 score on a scale Standard Deviation 0.97	3.37 score on a scale Standard Deviation 0.95	3.29 score on a scale Standard Deviation 0.94	3.42 score on a scale Standard Deviation 0.98	3.35 score on a scale Standard Deviation 0.98	3.36 score on a scale Standard Deviation 0.94	3.35 score on a scale Standard Deviation 0.96	3.36 score on a scale Standard Deviation 0.96	3.40 score on a scale Standard Deviation 0.96	3.31 score on a scale Standard Deviation 0.96

SECONDARY outcome

Timeframe: Baseline, 3 months, 6 months

Population: Participants who completed the TSRQ at 3 months; participants who completed the TSRQ at 6 months.

Change in treatment self-regulation from baseline to 3 and 6 months as measured using the Treatment Self-Regulation Questionnaire (TSRQ). The TSRQ assesses autonomous and controlled motivation for making changes in diet (15 items) and physical activity (15 items). Examples item: "Because I feel that I want to take responsibility for my own health" answered on a scale of 1 (not at all true) to 7 (very true)." Calculating the scores for the sub-scales will consist of averaging the items on that subscale. They are: Autonomous Regulation: 2, 3, 7, 10, 13, 16, 18, 19 Controlled Regulation: 1, 4, 5, 6, 8, 9, 11, 12, 14, 15, 17. Responses to the items within the subscale are averaged with the range of scores being 1 to 7. Higher values on each subscale indicate greater levels of that type of motivation. Outcomes are changes in autonomous and controlled motivation for diet at 3 and 6 months, and changes in autonomous and controlled motivation for activity at 3 and 6 months.

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=309 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=315 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=313 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=311 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=314 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=310 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=314 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=310 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Treatment Self-Regulation Score Autonomous motivation for diet baseline to 6 months	-0.17 score on a scale Standard Deviation 1.06	-0.18 score on a scale Standard Deviation 0.98	-0.12 score on a scale Standard Deviation 0.97	-0.23 score on a scale Standard Deviation 1.07	-0.14 score on a scale Standard Deviation 1.00	-0.21 score on a scale Standard Deviation 1.05	-0.20 score on a scale Standard Deviation 1.08	-0.15 score on a scale Standard Deviation 0.97	-0.17 score on a scale Standard Deviation 1.02	-0.18 score on a scale Standard Deviation 1.03
Treatment Self-Regulation Score Controlled motivation for diet baseline to 3 months	0.16 score on a scale Standard Deviation 1.10	0.06 score on a scale Standard Deviation 1.20	0.15 score on a scale Standard Deviation 1.17	0.06 score on a scale Standard Deviation 1.13	0.07 score on a scale Standard Deviation 1.15	0.14 score on a scale Standard Deviation 1.15	0.09 score on a scale Standard Deviation 1.06	0.13 score on a scale Standard Deviation 1.24	0.02 score on a scale Standard Deviation 1.17	0.20 score on a scale Standard Deviation 1.12
Treatment Self-Regulation Score Autonomous motivation for physical activity baseline to 6 months	-0.01 score on a scale Standard Deviation 1.07	0.03 score on a scale Standard Deviation 1.02	0.01 score on a scale Standard Deviation 0.91	0.02 score on a scale Standard Deviation 1.17	0.08 score on a scale Standard Deviation 1.00	-0.06 score on a scale Standard Deviation 1.09	0.00 score on a scale Standard Deviation 1.12	0.03 score on a scale Standard Deviation 0.97	0.04 score on a scale Standard Deviation 1.09	-0.02 score on a scale Standard Deviation 1.00
Treatment Self-Regulation Score Autonomous motivation for diet baseline to 3 months	-0.19 score on a scale Standard Deviation 0.93	-0.23 score on a scale Standard Deviation 0.87	-0.16 score on a scale Standard Deviation 0.87	-0.25 score on a scale Standard Deviation 0.92	-0.19 score on a scale Standard Deviation 0.85	-0.22 score on a scale Standard Deviation 0.94	-0.21 score on a scale Standard Deviation 0.90	-0.20 score on a scale Standard Deviation 0.90	-0.18 score on a scale Standard Deviation 0.89	-0.23 score on a scale Standard Deviation 0.91
Treatment Self-Regulation Score Controlled motivation for diet baseline to 6 months	0.17 score on a scale Standard Deviation 1.17	0.07 score on a scale Standard Deviation 1.16	0.16 score on a scale Standard Deviation 1.16	0.08 score on a scale Standard Deviation 1.17	0.12 score on a scale Standard Deviation 1.16	0.12 score on a scale Standard Deviation 1.17	0.17 score on a scale Standard Deviation 1.11	0.07 score on a scale Standard Deviation 1.22	0.03 score on a scale Standard Deviation 1.15	0.21 score on a scale Standard Deviation 1.17
Treatment Self-Regulation Score Autonomous motivation for physical activity baseline to 3 months	-0.07 score on a scale Standard Deviation 1.04	-0.06 score on a scale Standard Deviation 0.94	-0.07 score on a scale Standard Deviation 0.94	-0.06 score on a scale Standard Deviation 1.04	-0.02 score on a scale Standard Deviation 0.96	-0.11 score on a scale Standard Deviation 1.02	-0.02 score on a scale Standard Deviation 0.99	-0.12 score on a scale Standard Deviation 0.99	-0.03 score on a scale Standard Deviation 0.97	-0.10 score on a scale Standard Deviation 1.01
Treatment Self-Regulation Score Controlled motivation for physical activity baseline to 3 months	0.07 score on a scale Standard Deviation 1.14	0.14 score on a scale Standard Deviation 1.03	0.17 score on a scale Standard Deviation 1.04	0.04 score on a scale Standard Deviation 1.13	0.09 score on a scale Standard Deviation 1.03	0.12 score on a scale Standard Deviation 1.14	0.06 score on a scale Standard Deviation 1.03	0.16 score on a scale Standard Deviation 1.14	0.08 score on a scale Standard Deviation 1.08	0.13 score on a scale Standard Deviation 1.09
Treatment Self-Regulation Score Controlled motivation for physical activity baseline to 6 months	0.06 score on a scale Standard Deviation 1.11	0.17 score on a scale Standard Deviation 1.11	0.15 score on a scale Standard Deviation 1.10	0.08 score on a scale Standard Deviation 1.13	0.16 score on a scale Standard Deviation 1.07	0.07 score on a scale Standard Deviation 1.15	0.10 score on a scale Standard Deviation 1.08	0.14 score on a scale Standard Deviation 1.14	0.06 score on a scale Standard Deviation 1.10	0.17 score on a scale Standard Deviation 1.12

SECONDARY outcome

Timeframe: 3 months, 6 months

Population: Participants who completed the relatedness subscale at 3 months; participants who completed the relatedness subscale at 6 months.

Relatedness at 3 and 6 months as measured with 3 items adapted from the 8-item Relatedness subscale of the Basic Need Satisfaction at Work Scale. Examples include "The messages demonstrate caring about me as a person" and are scored on a Likert scale from 1 (strongly disagree) to 7 (strongly agree). Responses are averaged with a range of 1 to 7. Higher scores indicate a higher level of perceived relatedness from the intervention messages.

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=309 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=315 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=313 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=311 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=314 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=310 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=314 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=310 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Relatedness Score Relatedness at 3 Months	4.91 score on a scale Standard Deviation 1.47	4.95 score on a scale Standard Deviation 1.40	4.86 score on a scale Standard Deviation 1.42	5.01 score on a scale Standard Deviation 1.45	4.99 score on a scale Standard Deviation 1.42	4.88 score on a scale Standard Deviation 1.45	4.91 score on a scale Standard Deviation 1.40	4.96 score on a scale Standard Deviation 1.48	5.04 score on a scale Standard Deviation 1.43	4.83 score on a scale Standard Deviation 1.44
Relatedness Score Relatedness at 6 Months	4.79 score on a scale Standard Deviation 1.57	4.90 score on a scale Standard Deviation 1.51	4.83 score on a scale Standard Deviation 1.50	4.85 score on a scale Standard Deviation 1.58	4.91 score on a scale Standard Deviation 1.52	4.77 score on a scale Standard Deviation 1.56	4.86 score on a scale Standard Deviation 1.53	4.83 score on a scale Standard Deviation 1.55	4.93 score on a scale Standard Deviation 1.52	4.75 score on a scale Standard Deviation 1.55

SECONDARY outcome

Timeframe: Baseline to 6 months (daily)

Population: All randomized participants.

Mean number of days of complete dietary tracking summed over the 6-month study period.

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=309 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=315 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=313 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=311 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=314 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=310 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=314 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=310 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Diet Self-monitoring Adherence	73.3 days Standard Deviation 51.3	67.9 days Standard Deviation 48.1	69.3 days Standard Deviation 50.1	71.9 days Standard Deviation 49.4	69.2 days Standard Deviation 49.1	72.1 days Standard Deviation 50.4	74.9 days Standard Deviation 51.4	66.3 days Standard Deviation 47.6	69.7 days Standard Deviation 50.4	71.5 days Standard Deviation 49.0

SECONDARY outcome

Timeframe: Baseline to 6 months (daily)

Population: All randomized participants.

Mean number of days of self-weighing over the 6 month period.

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=309 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=315 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=313 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=311 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=314 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=310 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=314 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=310 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Weighing Adherence	90.2 days Standard Deviation 51.4	87.4 days Standard Deviation 49.6	87.5 days Standard Deviation 50.9	90.0 days Standard Deviation 50.1	87.9 days Standard Deviation 50.6	89.6 days Standard Deviation 50.5	90.5 days Standard Deviation 51.2	87.0 days Standard Deviation 49.8	88.6 days Standard Deviation 50.8	89.0 days Standard Deviation 50.3

SECONDARY outcome

Timeframe: Baseline to 6 months (daily)

Population: All randomized participants.

Mean number of days of physical activity tracking over the 6 month period as measured by Fitbit tracker wear.

Outcome measures

Outcome measures
Measure	Standard Diet Monitoring n=309 Participants Standard monitoring using smartphone tracking of all calorie intake.	Simplified Diet Monitoring n=315 Participants Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach.	Weekly Adaptive Activity Goals n=313 Participants Physical activity goals that adapt once each week using the participants' data derived from activity tracker.	Daily Adaptive Activity Goals n=311 Participants Physical activity goals that adapt once each day using the participants' data derived from activity tracker.	Fixed Message Decision Points n=314 Participants Message timing is fixed and evaluated at specific times each day to determine message eligibility.	Adaptive Message Decision Points n=310 Participants Message timing is adaptive and derived from individual user data to determine message eligibility.	Standard Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors.	Adaptive Message Decision Rules n=312 Participants Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress.	No Message Choice n=314 Participants Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Message Choice n=310 Participants Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Physical Activity Self-monitoring Adherence	134.1 days Standard Deviation 46.5	133.4 days Standard Deviation 45.3	133.2 days Standard Deviation 46.3	134.3 days Standard Deviation 45.4	132.7 days Standard Deviation 46.7	134.8 days Standard Deviation 45.0	133.9 days Standard Deviation 45.9	133.6 days Standard Deviation 45.8	131.4 days Standard Deviation 48.2	136.2 days Standard Deviation 43.2

Adverse Events

Condition 1

Serious events: 0 serious events

Other events: 5 other events

Deaths: 0 deaths

Condition 2

Serious events: 0 serious events

Other events: 2 other events

Deaths: 0 deaths

Condition 3

Serious events: 0 serious events

Other events: 3 other events

Deaths: 0 deaths

Condition 4

Serious events: 0 serious events

Other events: 5 other events

Deaths: 0 deaths

Condition 5

Serious events: 0 serious events

Other events: 2 other events

Deaths: 0 deaths

Condition 6

Serious events: 0 serious events

Other events: 4 other events

Deaths: 0 deaths

Condition 7

Serious events: 0 serious events

Other events: 1 other events

Deaths: 0 deaths

Condition 8

Serious events: 0 serious events

Other events: 3 other events

Deaths: 0 deaths

Condition 9

Serious events: 1 serious events

Other events: 4 other events

Deaths: 0 deaths

Condition 10

Serious events: 0 serious events

Other events: 7 other events

Deaths: 0 deaths

Condition 11

Serious events: 1 serious events

Other events: 4 other events

Deaths: 1 deaths

Condition 12

Serious events: 1 serious events

Other events: 1 other events

Deaths: 2 deaths

Condition 13

Serious events: 0 serious events

Other events: 2 other events

Deaths: 0 deaths

Condition 14

Serious events: 1 serious events

Other events: 3 other events

Deaths: 1 deaths

Condition 15

Serious events: 0 serious events

Other events: 2 other events

Deaths: 0 deaths

Condition 16

Serious events: 0 serious events

Other events: 4 other events

Deaths: 0 deaths

Condition 17

Serious events: 0 serious events

Other events: 3 other events

Deaths: 0 deaths

Condition 18

Serious events: 0 serious events

Other events: 1 other events

Deaths: 0 deaths

Condition 19

Serious events: 0 serious events

Other events: 1 other events

Deaths: 0 deaths

Condition 20

Serious events: 2 serious events

Other events: 3 other events

Deaths: 2 deaths

Condition 21

Serious events: 0 serious events

Other events: 2 other events

Deaths: 0 deaths

Condition 22

Serious events: 1 serious events

Other events: 4 other events

Deaths: 1 deaths

Condition 23

Serious events: 0 serious events

Other events: 2 other events

Deaths: 0 deaths

Condition 24

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Condition 25

Serious events: 1 serious events

Other events: 5 other events

Deaths: 1 deaths

Condition 26

Serious events: 1 serious events

Other events: 3 other events

Deaths: 1 deaths

Condition 27

Serious events: 0 serious events

Other events: 3 other events

Deaths: 0 deaths

Condition 28

Serious events: 0 serious events

Other events: 2 other events

Deaths: 0 deaths

Condition 29

Serious events: 0 serious events

Other events: 4 other events

Deaths: 0 deaths

Condition 30

Serious events: 0 serious events

Other events: 6 other events

Deaths: 0 deaths

Condition 31

Serious events: 0 serious events

Other events: 1 other events

Deaths: 0 deaths

Condition 32

Serious events: 0 serious events

Other events: 5 other events

Deaths: 0 deaths

Serious adverse events

Serious adverse events
Measure	Condition 1 n=18 participants at risk Core + Standard Diet Monitoring + Daily Activity Goal + Fixed Timing + Standard Content + No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 2 n=21 participants at risk Core + Standard Diet Monitoring + Daily Activity Goal + Fixed Timing + Standard Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 3 n=20 participants at risk Core + Standard Diet Monitoring + Daily Activity Goal + Fixed Timing + Adaptive Content + No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 4 n=18 participants at risk Core + Standard Diet Monitoring + Daily Activity Goal + Fixed Timing + Adaptive Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 5 n=20 participants at risk Core+Standard Diet Monitoring+Daily Activity Goal+Adaptive Timing+Standard Content+No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 6 n=18 participants at risk Core + Standard Diet Monitoring + Daily Activity Goal + Adaptive Timing + Standard Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 7 n=19 participants at risk Core+ Standard Diet Monitoring+ Daily Activity Goal+ Adaptive Timing+ Adaptive Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 8 n=20 participants at risk Core + Standard Diet Monitoring + Daily Activity Goal + Adaptive Timing + Adaptive Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 9 n=20 participants at risk Core + Standard Diet Monitoring + Weekly Activity Goal + Fixed Timing + Standard Content + No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 10 n=20 participants at risk Core + Standard Diet Monitoring + Weekly Activity Goal + Fixed Timing + Standard Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 11 n=20 participants at risk Core + Standard Diet Monitoring + Weekly Activity Goal + Fixed Timing + Adaptive Content + No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 12 n=19 participants at risk Core + Standard Diet Monitoring + Weekly Activity Goal + Fixed Timing + Adaptive Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 13 n=18 participants at risk Core+Standard Diet Monitoring+Weekly Activity Goal+Adaptive Timing+Standard Content+No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 14 n=19 participants at risk Core + Standard Diet Monitoring + Weekly Activity Goal + Adaptive Timing + Standard Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 15 n=20 participants at risk Core + Standard Diet Monitoring+ Weekly Activity Goal+ Adaptive Timing+ Adaptive Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 16 n=19 participants at risk Core + Standard Diet Monitoring + Weekly Activity Goal + Adaptive Timing + Adaptive Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 17 n=20 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Fixed Timing+ Standard Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 18 n=20 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Fixed Timing+ Standard Content+ Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 19 n=20 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Fixed Timing+ Adaptive Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 20 n=19 participants at risk Core + Simplified Diet Monitoring + Daily Activity Goal + Fixed Timing + Adaptive Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 21 n=20 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Adaptive Timing+ Standard Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 22 n=19 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Adaptive Timing+ Standard Content+ Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 23 n=20 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Adaptive Timing+ Adaptive Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 24 n=19 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Adaptive Timing+ Adaptive Content+ Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 25 n=19 participants at risk Core+ Simplified Diet Monitoring+ Weekly Activity Goal+ Fixed Timing+ Standard Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 26 n=20 participants at risk Core + Simplified Diet Monitoring + Weekly Activity Goal + Fixed Timing + Standard Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 27 n=20 participants at risk Core+ Simplified Diet Monitoring+ Weekly Activity Goal+ Fixed Timing+ Adaptive Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 28 n=20 participants at risk Core + Simplified Diet Monitoring + Weekly Activity Goal + Fixed Timing + Adaptive Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 29 n=20 participants at risk Core+ Simplified Diet Monitoring+ Weekly Activity Goal+ Adaptive Timing+ Standard Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 30 n=20 participants at risk Core+ Simplified Diet Monitoring+ Weekly Activity Goal+ Adaptive Timing+ Standard Content+ Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 31 n=20 participants at risk Core+ Simplified Diet Monitoring+ Weekly Activity Goal+ Adaptive Timing+ Adaptive Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 32 n=19 participants at risk Core + Simplified Diet Monitoring + Weekly Activity Goal + Adaptive Timing + Adaptive Content+Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Pregnancy, puerperium and perinatal conditions Miscarriage	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Leg injury	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Cardiac disorders Hospitalized for transient ischemic attacks	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Surgical and medical procedures Gall bladder removal	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Surgical and medical procedures Appendicitis, surgery and hospitalization	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Surgical and medical procedures Surgery	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Surgical and medical procedures Ileostomy secondary to parastomal hernia	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Foot fracture	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months

Other adverse events

Other adverse events
Measure	Condition 1 n=18 participants at risk Core + Standard Diet Monitoring + Daily Activity Goal + Fixed Timing + Standard Content + No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 2 n=21 participants at risk Core + Standard Diet Monitoring + Daily Activity Goal + Fixed Timing + Standard Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 3 n=20 participants at risk Core + Standard Diet Monitoring + Daily Activity Goal + Fixed Timing + Adaptive Content + No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 4 n=18 participants at risk Core + Standard Diet Monitoring + Daily Activity Goal + Fixed Timing + Adaptive Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 5 n=20 participants at risk Core+Standard Diet Monitoring+Daily Activity Goal+Adaptive Timing+Standard Content+No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 6 n=18 participants at risk Core + Standard Diet Monitoring + Daily Activity Goal + Adaptive Timing + Standard Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 7 n=19 participants at risk Core+ Standard Diet Monitoring+ Daily Activity Goal+ Adaptive Timing+ Adaptive Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 8 n=20 participants at risk Core + Standard Diet Monitoring + Daily Activity Goal + Adaptive Timing + Adaptive Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 9 n=20 participants at risk Core + Standard Diet Monitoring + Weekly Activity Goal + Fixed Timing + Standard Content + No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 10 n=20 participants at risk Core + Standard Diet Monitoring + Weekly Activity Goal + Fixed Timing + Standard Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 11 n=20 participants at risk Core + Standard Diet Monitoring + Weekly Activity Goal + Fixed Timing + Adaptive Content + No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 12 n=19 participants at risk Core + Standard Diet Monitoring + Weekly Activity Goal + Fixed Timing + Adaptive Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 13 n=18 participants at risk Core+Standard Diet Monitoring+Weekly Activity Goal+Adaptive Timing+Standard Content+No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 14 n=19 participants at risk Core + Standard Diet Monitoring + Weekly Activity Goal + Adaptive Timing + Standard Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 15 n=20 participants at risk Core + Standard Diet Monitoring+ Weekly Activity Goal+ Adaptive Timing+ Adaptive Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 16 n=19 participants at risk Core + Standard Diet Monitoring + Weekly Activity Goal + Adaptive Timing + Adaptive Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Standard Diet Monitoring: Standard monitoring using smartphone tracking of all calorie intake. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 17 n=20 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Fixed Timing+ Standard Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 18 n=20 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Fixed Timing+ Standard Content+ Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 19 n=20 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Fixed Timing+ Adaptive Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 20 n=19 participants at risk Core + Simplified Diet Monitoring + Daily Activity Goal + Fixed Timing + Adaptive Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 21 n=20 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Adaptive Timing+ Standard Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 22 n=19 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Adaptive Timing+ Standard Content+ Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 23 n=20 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Adaptive Timing+ Adaptive Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 24 n=19 participants at risk Core+ Simplified Diet Monitoring+ Daily Activity Goal+ Adaptive Timing+ Adaptive Content+ Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Daily): Physical activity goals that adapt once each day using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 25 n=19 participants at risk Core+ Simplified Diet Monitoring+ Weekly Activity Goal+ Fixed Timing+ Standard Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 26 n=20 participants at risk Core + Simplified Diet Monitoring + Weekly Activity Goal + Fixed Timing + Standard Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 27 n=20 participants at risk Core+ Simplified Diet Monitoring+ Weekly Activity Goal+ Fixed Timing+ Adaptive Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 28 n=20 participants at risk Core + Simplified Diet Monitoring + Weekly Activity Goal + Fixed Timing + Adaptive Content + Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Fixed): Message timing is fixed and evaluated at specific times each day to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 29 n=20 participants at risk Core+ Simplified Diet Monitoring+ Weekly Activity Goal+ Adaptive Timing+ Standard Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 30 n=20 participants at risk Core+ Simplified Diet Monitoring+ Weekly Activity Goal+ Adaptive Timing+ Standard Content+ Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Standard): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.	Condition 31 n=20 participants at risk Core+ Simplified Diet Monitoring+ Weekly Activity Goal+ Adaptive Timing+ Adaptive Content+ No Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (No): Participant choice does not drive adaptation of 1) message type delivered or 2) lapse support provision	Condition 32 n=19 participants at risk Core + Simplified Diet Monitoring + Weekly Activity Goal + Adaptive Timing + Adaptive Content+Choice Core: Behavioral weight loss core includes behavioral lessons, activity tracker, daily self-weighing, weekly tailored feedback summary. Simplified Diet Monitoring: Simplified diet monitoring using smartphone tracking of red foods using a traffic light approach. Adaptive Activity Goals (Weekly): Physical activity goals that adapt once each week using the participants' data derived from activity tracker. Message Decision Points (Adaptive): Message timing is adaptive and derived from individual user data to determine message eligibility. Message Decision Rules (Adaptive): Decision rules to determine eligibility to receive just-in-time messages consider participant's recent behaviors and overall progress. Message Choice (Yes): Participant choice drives adaptation of 1) message type delivered and 2) lapse support provision.
Injury, poisoning and procedural complications Deltoid sprain	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Concussion	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Shin splints	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Psychiatric disorders Palpitations from anxiety	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Ankle sprain	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months
Psychiatric disorders Anxiety	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Respiratory, thoracic and mediastinal disorders Asthma attacks/exacerbation	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Musculoskeletal and connective tissue disorders Back sprain	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Psychiatric disorders Depression	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months
Psychiatric disorders ADHD	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months
Nervous system disorders Fainting	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Foot pain	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Knee sprain	0.00% 0/18 • up to 6 months	4.8% 1/21 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Nervous system disorders Nerve inflammation, wrist and hand	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Cardiac disorders Heart palpitations	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Cardiac disorders High blood pressure	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Nervous system disorders Intracranial Hypertension and Neurogenic Thoracic Outlet Syndrome	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Knee injury	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Finger injury	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Pregnancy, puerperium and perinatal conditions Miscarriage	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
General disorders Motor vehicle accident	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/21 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	15.0% 3/20 • Number of events 3 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	10.0% 2/20 • Number of events 2 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Hand and wrist pain	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Musculoskeletal and connective tissue disorders Plantar fasciitis	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Nervous system disorders Migraine	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Musculoskeletal and connective tissue disorders Neck and shoulder pain	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Metabolism and nutrition disorders Diabetes	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Pregnancy, puerperium and perinatal conditions Pregnancy	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Cardiac disorders Heart trouble	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Wrist sprain	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	10.5% 2/19 • Number of events 2 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Toe sprain	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Nervous system disorders Nerve pain/sciatica	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Psychiatric disorders Eating disorder	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Psychiatric disorders PTSD, started medication	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Musculoskeletal and connective tissue disorders Chest muscle strain secondary to pneumonia	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Musculoskeletal and connective tissue disorders Muscle strain	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	11.1% 2/18 • Number of events 2 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	10.0% 2/20 • Number of events 2 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	15.8% 3/19 • Number of events 3 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Toe injury	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Surgical and medical procedures Wisdom tooth removal	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Cardiac disorders WPW syndrome (congenital heart defect)	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Injury, poisoning and procedural complications Fracture	5.6% 1/18 • Number of events 1 • up to 6 months	4.8% 1/21 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months
Respiratory, thoracic and mediastinal disorders Breathing problems	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Psychiatric disorders Switched medication for mental health disorder	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Musculoskeletal and connective tissue disorders Sternum injury	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months
Psychiatric disorders Other mental health treatment	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	5.6% 1/18 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.3% 1/19 • Number of events 1 • up to 6 months
Injury, poisoning and procedural complications Neck, back, and shoulder injury	0.00% 0/18 • up to 6 months	0.00% 0/21 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	5.0% 1/20 • Number of events 1 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/18 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/19 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/20 • up to 6 months	0.00% 0/19 • up to 6 months

Additional Information

Brooke Nezami, PhD

University of North Carolina at Chapel Hill

Phone: 919-966-5852

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place