Investigation of Clinical Effectiveness of Propolis Extracts as Food Supplements in Patients With SARS-CoV-2(COVID-19)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-15

Study Completion Date

2021-08-15

Brief Summary

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Primary purpose: To investigate the effect of propolis, a food supplement product, on healing parameters in patients with COVID 19. Secondary purpose: To provide a new supportive treatment in Covid 19 treatment. In the present study to examine the effect of the use of propolis on healing parameters (laboratory and imaging) in patients with COVID 19; Propolis, which has antiviral properties, has also been used in humans in the COVID19 pandemic as of 2020. However, in these studies, an alcohol-soluble extract of propolis was used. Despite the disadvantages of its use in alcohol, it is clear that water and olive oil extracts of Propolis are safer for humans. Therefore, water extracts of propolis will be used in the study.

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Detailed Description

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Conditions

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SARS-CoV2 Infection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

first group treated with water extracts of propolis second group treated with olive oil extracts of propolis including perga third group treated with no bee product

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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water extract of propolis

Patients given 2 ml of aqueous propolis extract (50mg / ml) orally 3 times a day for 1 week

Group Type EXPERIMENTAL

propolis

Intervention Type DIETARY_SUPPLEMENT

Propolis may be blocked virus entry to cells, and some receptor binding and some cell signal molecules

olive oil extract of propolis including perga

Patients given 1 ml oily propolis extract (64 mg / ml) + 1 ml oily perga extract (120 mg / ml) orally 3 times a day for 1 week

Group Type EXPERIMENTAL

propolis

Intervention Type DIETARY_SUPPLEMENT

Propolis may be blocked virus entry to cells, and some receptor binding and some cell signal molecules

control

control group (patients not given any investigational product)

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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propolis

Propolis may be blocked virus entry to cells, and some receptor binding and some cell signal molecules

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Patients over the age of 18 who do not need a ventilator who are inpatient in the Covid service
* Patients under the age of 60 who do not need a ventilator who are inpatient in the Covid service

Exclusion Criteria

* patients do not have oral intake
* patients whose informed consent form is not approved
* patients who need a ventilator
* pregnant women
* children

Minimum Eligible Age

18 Years

Maximum Eligible Age

59 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes