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Impact of Obesity on Post-operative Cognitive Dysfunction: Role of Adipose Tissue

NCT ID: NCT04907565

Last Updated: 2024-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

408 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-09-21

Study Completion Date

2025-09-21

Brief Summary

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This research aims at describing the relationship between white adipose tissue inflammation and post-operative cognitive dysfunctions.The possible link between inflammatory cytokines secretions of the white adipose tissue of a surgical wound and the arising of patient's cognitive dysfunction in the post-operative course will be investigated. The hypothesis is that obese patient's inflammation of the white adipose tissue leads to cognitive dysfunction.

Detailed Description

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The postoperative cognitive dysfunctions (POCD) are characterized by delirium and cognitive impairment. The delirium is defined by an acute altered attention with a fluctuating course. The post-operative cognitive impairment involves the early alteration of different functions including memory, attention and cognitive flexibility. POCD have a major impact in patient's morbidity. They are linked to the systemic inflammation induced by the surgical wound. The systemic inflammation leads to the rupture of the brain-blood barrier and to hippocampal inflammation. As hippocampus mediates the principal cognitive functions, hippocampal inflammation leads to POCD. Orthopedic and cardiac surgery are particularly concerned. Obesity is growing condition in the French population. It is linked to chronic systemic inflammation and altered cognitive functions. We think that obese people may present a susceptibility to POCD because of the pre-operative systemic inflammation.

Conditions

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Obesity Cognitive Impairment Post-Operative Confusion

Keywords

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Obesity Post-operative cognitive dysfunction Inflammation Inflammatory cytokines

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Obese patients

BMI \>30kg/m2

Blood sampling

Intervention Type BIOLOGICAL

4 tubes of 7 mL of blood will be collected

white adipose tissue sampling

Intervention Type BIOLOGICAL

At the beginning of the surgery, samples of white adipose tissue from the surgical wound will be collected.

non obese patients

BMI between 18 to 29kg/m2

Blood sampling

Intervention Type BIOLOGICAL

4 tubes of 7 mL of blood will be collected

white adipose tissue sampling

Intervention Type BIOLOGICAL

At the beginning of the surgery, samples of white adipose tissue from the surgical wound will be collected.

Interventions

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Blood sampling

4 tubes of 7 mL of blood will be collected

Intervention Type BIOLOGICAL

white adipose tissue sampling

At the beginning of the surgery, samples of white adipose tissue from the surgical wound will be collected.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* patient about to receive a hip arthroplasty under general anesthesia, elective cardiac surgery with cardiopulmonary bypass,
* patient with a MMSE score \> or = 20(/30),
* patient able to give informed consent

Exclusion Criteria

* emergency surgery, or surgery in a septic context,
* patient with a known dementia or altered MMSE score (under 20)
Minimum Eligible Age

60 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Toulouse

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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François Labaste, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Toulouse

Locations

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Purpan University Hospital

Toulouse, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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François Labaste, MD, PhD

Role: CONTACT

Phone: 561322822

Email: [email protected]

Facility Contacts

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François Labaste, MD, PhD

Role: primary

Other Identifiers

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RC31/21/0014

Identifier Type: -

Identifier Source: org_study_id