Trial Outcomes & Findings for Enhancing Cognitive Control Abilities Using Mobile Technology in a Senior Living Community (NCT NCT04905849)

Results Overview

ACE is a custom mobile cognitive health assessment battery that presents paradigms typically used in standard cognitive neuroscience laboratories. Here the investigators will assess a measure of (1) Attention and (2) Working memory in the ACE software.

Recruitment status

TERMINATED

Study phase

NA

Target enrollment

12 participants

Primary outcome timeframe

At Baseline and post intervention at the 6 week mark

Results posted on

2025-07-03

Participant Flow

Participant milestones

Participant milestones
Measure	Adaptive Cognitive Control Trainer (ACCT) There are three modules within the game, each training a different aspect of cognitive control (attention, goal management, working memory): a visual search task for attention abilities, a spatial span task for working memory, and a task switching paradigm for goal management abilities. There are also 3 different levels of difficulty associated with each module; advancing to the next level delivers an advanced challenge that enhances the difficulty in performing the given cognitive task. Participants advance to the next level of difficulty following 6 training sessions occurring over 2 weeks, with the total training experience being 6 weeks of training (3 days/week), with each training session lasting 36 minutes (not including self-paced breaks).	Active Control Group An active control application will be used for this arm. The total training experience here will also be for 6 weeks (3 days/week), with each training session lasting \~30 minutes (not including self-paced breaks). Here an app that is matched in terms of expectancy of benefits compared to our training groups will be determined by questioning 100 naïve individuals to predict their expected improvement on each cognitive domain across a multitude of possible applications. Active Control App: The app used here is undergoing expectancy-matching at the present time, will be updated with the final app characteristics when completed out of a list of several possibilities
Overall Study STARTED	12	0
Overall Study COMPLETED	6	0
Overall Study NOT COMPLETED	6	0

Reasons for withdrawal

Reasons for withdrawal
Measure	Adaptive Cognitive Control Trainer (ACCT) There are three modules within the game, each training a different aspect of cognitive control (attention, goal management, working memory): a visual search task for attention abilities, a spatial span task for working memory, and a task switching paradigm for goal management abilities. There are also 3 different levels of difficulty associated with each module; advancing to the next level delivers an advanced challenge that enhances the difficulty in performing the given cognitive task. Participants advance to the next level of difficulty following 6 training sessions occurring over 2 weeks, with the total training experience being 6 weeks of training (3 days/week), with each training session lasting 36 minutes (not including self-paced breaks).	Active Control Group An active control application will be used for this arm. The total training experience here will also be for 6 weeks (3 days/week), with each training session lasting \~30 minutes (not including self-paced breaks). Here an app that is matched in terms of expectancy of benefits compared to our training groups will be determined by questioning 100 naïve individuals to predict their expected improvement on each cognitive domain across a multitude of possible applications. Active Control App: The app used here is undergoing expectancy-matching at the present time, will be updated with the final app characteristics when completed out of a list of several possibilities
Overall Study The COVID pandemic devastated this study, as Brookdale efforts focused on resident health and safety	6	0

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Adaptive Cognitive Control Trainer (ACCT) n=6 Participants There are three modules within the game, each training a different aspect of cognitive control (attention, goal management, working memory): a visual search task for attention abilities, a spatial span task for working memory, and a task switching paradigm for goal management abilities. There are also 3 different levels of difficulty associated with each module; advancing to the next level delivers an advanced challenge that enhances the difficulty in performing the given cognitive task. Participants advance to the next level of difficulty following 6 training sessions occurring over 2 weeks, with the total training experience being 6 weeks of training (3 days/week), with each training session lasting 36 minutes (not including self-paced breaks).	Active Control Group An active control application will be used for this arm. The total training experience here will also be for 6 weeks (3 days/week), with each training session lasting \~30 minutes (not including self-paced breaks). Here an app that is matched in terms of expectancy of benefits compared to our training groups will be determined by questioning 100 naïve individuals to predict their expected improvement on each cognitive domain across a multitude of possible applications. Active Control App: The app used here is undergoing expectancy-matching at the present time, will be updated with the final app characteristics when completed out of a list of several possibilities	Total n=6 Participants Total of all reporting groups
Age, Continuous	72 years STANDARD_DEVIATION 5.5 • n=6 Participants	—	72 years STANDARD_DEVIATION 5.5 • n=6 Participants
Sex: Female, Male Female	2 Participants n=6 Participants	—	2 Participants n=6 Participants
Sex: Female, Male Male	4 Participants n=6 Participants	—	4 Participants n=6 Participants
Race and Ethnicity Not Collected	—	—	0 Participants Race and Ethnicity were not collected from any participant.
ACE-X CPT-	6 Participants n=6 Participants	0 Participants	6 Participants n=6 Participants
ACE-X Spatial Span	6 Participants n=6 Participants	0 Participants	6 Participants n=6 Participants

PRIMARY outcome

Timeframe: At Baseline and post intervention at the 6 week mark

Population: Individuals from Brookdale Senior Living Communities from across U.S. We counted How Many participants attempted to complete the ACE-X battery.

ACE is a custom mobile cognitive health assessment battery that presents paradigms typically used in standard cognitive neuroscience laboratories. Here the investigators will assess a measure of (1) Attention and (2) Working memory in the ACE software.

Outcome measures

Outcome measures
Measure	Adaptive Cognitive Control Trainer (ACCT) n=6 Participants There are three modules within the game, each training a different aspect of cognitive control (attention, goal management, working memory): a visual search task for attention abilities, a spatial span task for working memory, and a task switching paradigm for goal management abilities. There are also 3 different levels of difficulty associated with each module; advancing to the next level delivers an advanced challenge that enhances the difficulty in performing the given cognitive task. Participants advance to the next level of difficulty following 6 training sessions occurring over 2 weeks, with the total training experience being 6 weeks of training (3 days/week), with each training session lasting 36 minutes (not including self-paced breaks).	Active Control Group An active control application will be used for this arm. The total training experience here will also be for 6 weeks (3 days/week), with each training session lasting \~30 minutes (not including self-paced breaks). Here an app that is matched in terms of expectancy of benefits compared to our training groups will be determined by questioning 100 naïve individuals to predict their expected improvement on each cognitive domain across a multitude of possible applications. Active Control App: The app used here is undergoing expectancy-matching at the present time, will be updated with the final app characteristics when completed out of a list of several possibilities
Number of Participants Who Attempted to Complete the Adaptive Cognitive Evaluation (ACE) From Baseline at 6 Weeks	6 Participants	0 Participants

SECONDARY outcome

Timeframe: At Baseline and post intervention at the 6 week mark

Population: This measure was not collected in the end; none of the participants completed this measurement

The Everyday Cognition Scale (ECog) measures the ability to perform everyday tasks that demand memory, language, visuospatial abilities, planning, organization, and divided attention. The ECog consists of a global and domain scores for each of the previously described categories, and is scored as follows: 1= better or no change compared to 10 years earlier, 2= questionable/occasionally worse compared to 10 years earlier, 3= consistently a little worse compared to 10 years earlier, 4= consistently much worse compared to 10 years earlier. Thus, the lower the overall score is on this measure at both the global and domain score level, the better one is performing with respect to their cognition.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: At Baseline and post intervention at the 6 week mark

Population: No data was collected in the end for this measure, as no participants completed this measure.

The Cognitive Failures Questionnaire (CFQ) assesses participant distractibility. The CFQ score ranges from 0 to 100, with the lower the overall score is on this measure, the better one is performing with respect to their cognition.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: At Baseline and post intervention at the 6 week mark

Population: Note that no data was collected for this measure, as none of the participants completed this requested survey.

The general health and well-being (SF-36) score assesses participant health. The SF-36 score ranges from 0 to 100. The higher the overall score is on this measure, the better one is performing with respect to their health and well-being.

Outcome measures

Outcome data not reported

Adverse Events

Adaptive Cognitive Control Trainer (ACCT)

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Active Control Group

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Joaquin A. Anguera, Associate Professor

UC San Francisco

Phone: 415 502 7322

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place