Cellular Senescence and COVID-19 Long-Hauler Syndrome

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-03-01

Study Completion Date

2026-12-31

Brief Summary

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The purpose of this study is to test if senescent cells and their secretome contribute to Long-Hauler Syndrome and if a clinical trial of senolytic drugs, which selectively eliminate senescent cells, should be initiated.

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Detailed Description

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Conditions

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SARS-CoV2 Infection

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Longhauler's Syndrome Cohort

Subject's with longhaulers

No interventions assigned to this group

Control Cohort

Control cohort will not have had a known case of COVID-19 or Longhauler's syndrome

No interventions assigned to this group

COVID Control Cohort

Subjects who have had COVID-19 but no known Longhauler's syndrome

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Ability to give informed consent or LAR.
* At least 18 years old.
* Ability of subject or LAR to read and speak the English language.
* Positive PCR or antibody test within 12 months of initial study visit.
* Patient of the Long-Hauler Syndrome clinic and differential diagnosis of Long-Hauler Syndrome.

* Ability to give informed consent
* At least 18 years old
* Ability of subject to read and speak the English language

* Ability to give informed consent.
* At least 18 years old.
* Ability of subject to read and speak the English language.
* Known case of COVID-19.

Exclusion Criteria

* Any potential participant who refuses medical record review.
* Pregnant females.
* Incarcerated individuals.
* Inability to cooperate or any medical condition that, in the opinion of the investigator, interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study.

Control Cohort -

* Known case of COVID-19.
* Any potential participant who refuses medical record review.
* Pregnant females.
* Incarcerated individuals.
* Inability to cooperate or any medical condition that interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study.

COVID-19 Control Cohort

* Known Longhauler's syndrome/Post-COVID
* Any potential participant who refuses medical record review.
* Pregnant females.
* Incarcerated individuals.
* Inability to cooperate or any medical condition that interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes